(2S,3S,4R)-1-O-(A-D-吡喃半乳糖基)-2-(N-二十六烷酸酰胺)-1,3,4-十八烷三醇
中文名称 | (2S,3S,4R)-1-O-(A-D-吡喃半乳糖基)-2-(N-二十六烷酸酰胺)-1,3,4-十八烷三醇 |
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中文同义词 | (2S,3S,4R)-1-O-(A-D-吡喃半乳糖基)-2-(N-二十六烷酸酰胺)-1,3,4-十八烷三醇;-半乳糖神经酰胺;Α-半乳糖神经酰胺;7000克朗;(2S,3S,4R)-1-O-(Α-D-吡喃半乳糖基)-2-(N-二十六烷酰胺)-1,3,4-十八烷三醇;受体激动剂系列 |
英文名称 | KRN7000 |
英文同义词 | KRN7000;N-[(1S,2S,3R)-1-[(α-D-Galactopyranosyloxy)Methyl]-2,3-dihydroxyheptadecyl]hexacosanaMide;α-Galactosyl CeraMide;α-Galactosyl CeraMide;Α-GALACTOSYL CERAMIDE;Α-GALACTOSYL CERAMIDE;1-O-(alpha-D-galactosyl)-N-hexacosanoylphytosphingosine;(2S,3S,4R)-1-O-(α-D-Galactosyl)-N-hexacosanoyl-2-amino-1,3,4-octadecanetriol |
CAS号 | 158021-47-7 |
分子式 | C50H99NO9 |
分子量 | 858.32 |
EINECS号 | |
相关类别 | 脂类;糖脂;化合物;生化试剂;试剂盒-细胞分析试剂盒;Amino Acids 13C, 2H, 15N;Amino Acids & Derivatives;Protein Kinase Inhibitors and Activators;小分子 |
Mol文件 | 158021-47-7.mol |
结构式 |
(2S,3S,4R)-1-O-(A-D-吡喃半乳糖基)-2-(N-二十六烷酸酰胺)-1,3,4-十八烷三醇 性质
熔点 | 125-130°C |
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沸点 | 939.8±65.0 °C(Predicted) |
密度 | 1.04±0.1 g/cm3(Predicted) |
储存条件 | -20°C Freezer |
溶解度 | 微溶于吡啶(加热) |
形态 | 白色固体。 |
酸度系数(pKa) | 12.92±0.70(Predicted) |
颜色 | 白色至浅棕色 |
稳定性 | 吸湿性 |
CAS 数据库 | 158021-47-7 |
NKT cell
Culture supernatants of activated Vα24+NKT-cell cultures stimulated with α-Galactosylceramide pulsed monocyte-derived dendritic cells (Mo-DCs) exhibits antiproliferative activities against melanoma cells. This effect is predominantly due to release of IFN-γ, and to a lesser extent IL-12. Other cytokines, including IL-4 and IL-10, are released but these cytokines have less antiproliferative effects. Vα24+NKT-cells stimulated by α-Galactosylceramide-pulsed Mo-DCs have anti-tumour activities against human melanoma through antiproliferative effects exerted by soluble mediators.
α-Galactosylceramide treatment can protect against spontaneous, carcinogen-, or oncogene-induced primary tumor formation in mice. Consistent with a prime role for IFN-γ in NKT cell-mediated tumor responses, a C-glycoside analog of α-Galactosylceramide that preferentially stimulated IFN-γ production is even more effective than α-Galactosylceramide at preventing metastases of the B16 melanoma.
Since α-Galactosylceramide shows a potent antitumor activity and stimulates the lymphocyte proliferation (LP) on allogeneic mixed lymphocyte reaction (MLR) in the mouse, α-Galactosylceramide is considered to be a nonspecific immunostimulating agent which is a biological response modifier.
安全信息
WGK Germany | 3 |
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海关编码 | 2940.00.6000 |
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/04/30 | G0509 | α-半乳糖神经酰胺 α-Galactosylceramide | 158021-47-7 | 1mg | 1475元 |
2024/04/30 | HY-102022 | (2S,3S,4R)-1-O-(A-D-吡喃半乳糖基)-2-(N-二十六烷酸酰胺)-1,3,4-十八烷三醇 α-Galactosylceramide | 158021-47-7 | 1mg | 2475元 |