(S)-4-(4'-氯联苯-4-基)-4-氧代-2-(苯硫基甲基)丁酸
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- CAS号:
- 179545-77-8
- 英文名:
- Tanomastat
- 英文别名:
- D03802;TANOMASTAT;Tanomastat (usan/inn);(S)-4'-Chloro-g-oxo-a-[(phenylthio)methyl][1,1'-biphenyl]-4-butanoic acid;(S)-4-[4-(4-Chlorophenyl)phenyl]-4-oxo-2-(phenylsulfanylmethyl)butanoic acid;1,1'-Biphenyl]-4-butanoic acid, 4'-chloro-γ-oxo-α-[(phenylthio)methyl]-, (αS)-;BAY12-9566,(S)-4Chloro-g-oxo-a-[(phenylthio)methyl][1,1biphenyl]-4-butanoicAcid;[1,1'-Biphenyl]-4-butanoic acid, 4'-chloro-γ-oxo-α-[(phenylthio)methyl]-, (αS)-;(S)-4-(4'-Chloro-[1,1'-biphenyl]-4-yl)-4-oxo-2-((phenylthio)methyl)butanoic acid
- 中文名:
- (S)-4-(4'-氯联苯-4-基)-4-氧代-2-(苯硫基甲基)丁酸
- 中文别名:
- 化合物 T16986;(S)-4-(4'-氯联苯-4-基)-4-氧代-2-(苯硫基甲基)丁酸
- CBNumber:
- CB0506810
- 分子式:
- C23H19ClO3S
- 分子量:
- 410.91
- MOL File:
- 179545-77-8.mol
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(S)-4-(4'-氯联苯-4-基)-4-氧代-2-(苯硫基甲基)丁酸化学性质
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熔点:
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110-110.5°C
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沸点:
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620.1±55.0 °C(Predicted)
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密度:
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1.33±0.1 g/cm3(Predicted)
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储存条件:
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Sealed in dry,2-8°C
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溶解度:
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Acetone (Slightly), Chloroform (Slightly), Ethyl Acetate (Slightly)
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形态:
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Solid
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酸度系数(pKa):
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4.01±0.23(Predicted)
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颜色:
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White to Off-White
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CAS 数据库:
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179545-77-8
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(S)-4-(4'-氯联苯-4-基)-4-氧代-2-(苯硫基甲基)丁酸性质、用途与生产工艺
Tanomastat (BAY 12-9566) 是一种口服生物有效的含锌羧基的非肽联苯基质金属蛋白酶 (MMPs) 抑制剂。抑制MMP-2、MMP-3、MMP-9、MMP-13 的 Ki 值分别为 11、143、301 和 1470 nM。Tanomastat 在几种实验性肿瘤模型中具有抗侵袭和抗转移活性。
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MMP-2
11 nM (Ki)
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MMP-3
143 nM (Ki)
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MMP-9
301 nM (Ki)
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MMP-13
1470 nM (Ki)
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Tanomastat (BAY 12-9566) (1-10000 nM; 6 hours) prevents matrix invasion by endothelial cells in a concentration-dependent manner (IC
50
=840 nM), without affecting cell proliferation.
Tanomastat (BAY 12-9566) (1-00 µM; 5 days) inhibits tubule formation completely at 15-100 µM.
Tanomastat (BAY 12-9566) (100 mg/kg; p.o.; daily for a 7-week period) inhibits local tumor regrowth without causing any toxic effect, and inhibits the number and volume of lung metastases.
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Animal Model:
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Six- to eight-week-old female BALB/c nude mice (bearing MDA-MB-435 cells)
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Dosage:
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100 mg/kg
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Administration:
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p.o.; daily for a 7-week period
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Result:
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Inhibited local tumor regrowth by 58% without causing any toxic effect, and inhibited the number and volume of lung metastases by 57 and 88%, respectively.
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用途
A Matrix Metalloproteinase inhibitor. An angiogenesis inhibitor.
Optical Rotation +82℃ (C 1.5 acetone).
(S)-4-(4'-氯联苯-4-基)-4-氧代-2-(苯硫基甲基)丁酸
上下游产品信息
上游原料
下游产品
(S)-4-(4'-氯联苯-4-基)-4-氧代-2-(苯硫基甲基)丁酸
生产厂家
179545-77-8, (S)-4-(4'-氯联苯-4-基)-4-氧代-2-(苯硫基甲基)丁酸 相关搜索:
- Sulfur & Selenium Compounds
- Pharmaceuticals
- Intermediates & Fine Chemicals
- Inhibitors
- Chiral Reagents
- C23H19ClO3S
- 化合物 T16986
- (S)-4-(4'-氯联苯-4-基)-4-氧代-2-(苯硫基甲基)丁酸
- 179545-77-8
- 1,1'-Biphenyl]-4-butanoic acid, 4'-chloro-γ-oxo-α-[(phenylthio)methyl]-, (αS)-
- [1,1'-Biphenyl]-4-butanoic acid, 4'-chloro-γ-oxo-α-[(phenylthio)methyl]-, (αS)-
- (S)-4-(4'-Chloro-[1,1'-biphenyl]-4-yl)-4-oxo-2-((phenylthio)methyl)butanoic acid
- Tanomastat (usan/inn)
- D03802
- (S)-4-[4-(4-Chlorophenyl)phenyl]-4-oxo-2-(phenylsulfanylmethyl)butanoic acid
- (S)-4'-Chloro-g-oxo-a-[(phenylthio)methyl][1,1'-biphenyl]-4-butanoic acid
- BAY12-9566,(S)-4Chloro-g-oxo-a-[(phenylthio)methyl][1,1biphenyl]-4-butanoicAcid
- TANOMASTAT