羟嗪
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- CAS号:
- 68-88-2
- 英文名:
- Hydroxyzine
- 英文别名:
- Atara;Atarox;Aterax;NP 212;Tran-Q;Atarax;Atazina;Deinait;UCB 492;Pamazone
- 中文名:
- 羟嗪
- 中文别名:
- 羟嗪;羟嗪杂质;2-[2-[4-(4-氯苯基)苯甲基-1-哌嗪基]乙氧基]-乙醇;2-[2-[4-[(4-氯苯基)-苯甲基]哌嗪-1-基]乙氧基]乙醇;2-(2-(4-((4-氯苯基)(苯基)甲基)哌嗪-1-基)乙氧基)乙醇
- CBNumber:
- CB2547530
- 分子式:
- C21H27ClN2O2
- 分子量:
- 374.9
- MOL File:
- 68-88-2.mol
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羟嗪化学性质
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熔点:
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190°C
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沸点:
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250 °C(Press: 0.1 Torr)
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密度:
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1.1020 (rough estimate)
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折射率:
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1.5400 (estimate)
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储存条件:
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2-8°C
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溶解度:
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Chloroform (Slightly), DMSO (Sparingly), Ethanol (Slightly), Methanol (Slightly,
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形态:
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Oil to Gel
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酸度系数(pKa):
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pKa 1.96± 0.05；7.40± 0.03(H2O,t =24.5±0.5)(Approximate)
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颜色:
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Colourless to Yellow
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水溶解性:
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< 700 mg/mL
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BCS Class:
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2
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NIST化学物质信息:
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Hydroxyzine base(68-88-2)
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EPA化学物质信息:
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Hydroxyzine (68-88-2)
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羟嗪性质、用途与生产工艺
Hydroxyzine，一种苯二氮卓抗组胺剂 (antihistamine)，作为口服活性组胺 H1 受体 (histamine H1-receptor) 和血清素拮抗剂。Hydroxyzine 具有抗焦虑作用，可用于广泛性焦虑障碍的研究。
Hydroxyzine dihydrochloride inhibits carbachol (10 μM)-induced serotonin release by 34% at 10 μM, by 25% 1 μM and by 17% 0.1 μM in pretreated bladder slices for 60 min.
Hydroxyzine dihydrochloride (12.5 mg/kg, 25 mg/kg and 50 mg/kg i.p.) shows little direct analgesic activity but markedly potentiates only the effect of morphine on the vocalization after-discharge which represents the affective component of pain in rats. Hydroxyzine dihydrochloride (50 mg/kg i.p.) potentiates morphine on the tail-flick test, while Hydroxyzine (12.5 mg/kg i.p.) decreases morphine antinociception in rats.
羟嗪
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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| 2024/01/25 | HY-B0548 | Hydroxyzine | | 100 mg | 650元 |
羟嗪
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羟嗪国内生产厂家
68-88-2, 羟嗪 相关搜索:
- Pharmaceuticals
- Intermediates & Fine Chemicals
- Heterocycles
- Aromatics
- 医药原料
- C21H27ClN2O2
- 2-(2-(4-((4-氯苯基)(苯基)甲基)哌嗪-1-基)乙氧基)乙醇
- 羟嗪杂质
- 羟嗪
- 2-[2-[4-[(4-氯苯基)-苯甲基]哌嗪-1-基]乙氧基]乙醇
- 2-[2-[4-(4-氯苯基)苯甲基-1-哌嗪基]乙氧基]-乙醇
- 68-88-2
- Pregnenolone Impurity 8
- anxiety,Inhibitor,Histamine Receptor,itching,GAD,inhibit,nausea,tension,Hydroxyzine,disorder
- Hydroxyzine base
- Hydroxyzine free base
- Hydroxyzine USP/EP/BP
- 2-[2-[4-[(4-chlorophenyl)-phenylmethyl]piperazin-1-yl]ethoxy]ethanol hydron dichloride
- HYDROXYZINE;NSC 169188;U.C.B 4492
- 2-[2-[4-[(4-Chlorophenyl)-phenyl-methyl]piperazin-1-yl]ethoxy]ethanol
- 1-(4-Chloro-alpha-phenylbenzyl)-4-((2-(2-hydroxyethoxy)ethyl)piperazine)
- 2-[2-[4-[α-(4-Chlorophenyl)benzyl]piperazin-1-yl]ethoxy]ethanol
- 2-[4-(p-Chloro-a-phenylbenzyl)-1-piperazinyl]ethoxy]ethanol
- Ethanol, 2-[2-[4-(p-chloro-phenylbenzyl)-
- 1-piperazinyl]ethoxy]-
- Hydroxyzine See: H996500
- Hydroxyzine
- 2-(2-(4-((4-Chlorophenyl)(phenyl)methyl)-piperazin-1-yl)ethoxy)etha
- 1-(4-Chloro-alpha-phenylbenzyl)-4-((2-(2-hydroxyet
- Ataraxoid
- Atarax base
- Atarax
- Atara
- 2-(2-(4-[(4-Chlorophenyl)(phenyl)methyl]-1-piperazinyl)ethoxy)ethanol
- 2-(2-(4-(p-Chloro-alpha-phenylbenzyl)-1-piperazinyl)ethoxy)ethanol
- 1-(p-Chlorodiphenylmethyl)-4-(2-(2-hydroxyethoxy)ethyl)piperazine
- 1-(p-Chlorobenzhydryl)-4-(2-(2-hydroxyethoxy)ethyl)piperazine
- 1-(p-Chlorobenzhydryl)-4-(2-(2-hydroxyethoxy)ethyl)diethylenediamine
- 1-(p-Chloro-alpha-phenylbenzyl)-4-(2-((2-hydroxyethoxy)ethyl)piperazine
- 2-(2-(4-(4-chlorobenzhydryl)piperazin-1-yl)ethoxy)ethanol
- Vistaril
- Vesparaz-Wirkstoff
- UCB-4492
- UCB 492
- U.CB 4492
- U.C.B 4492
- Traquizine
- Tranquizine
- Tran-Q
- Plaxidol
- Placidol
- Paxistil
- Parenteral
- Pamazone
- NP 212
- Nevrolaks
- Neurozina
- neo-Calma