左色满卡林
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- CAS号:
- 94535-50-9
- 英文名:
- LEVCROMAKALIM
- 英文别名:
- brl38227;lemakalim;Brn 3622889;levcromakelim;LEVCROMAKALIM;LevkroMakaliM;(3s-trans)-yrrolidinyl);Potassium Channel,KcsA,Inhibitor,inhibit,BRL38227,BRL-38227,Levcromakalim;(3β,4α)-3-Hydroxy-2,2-dimethyl-4-(2-oxopyrrolidin-1-yl)chroman-6-carbonitrile;(3S,4R)-3-hydroxy-2,2-dimethyl-4-(2-oxopyrrolidin-1-yl)chroman-6-carbonitrile
- 中文名:
- 左色满卡林
- 中文别名:
- 左克罗卡林;左色满卡林
- CBNumber:
- CB5104507
- 分子式:
- C16H18N2O3
- 分子量:
- 286.33
- MOL File:
- 94535-50-9.mol
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左色满卡林化学性质
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熔点:
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242-244°
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比旋光度:
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D26 -52.2° (c = 1 in chloroform)
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沸点:
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482.3±45.0 °C(Predicted)
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密度:
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1.31±0.1 g/cm3(Predicted)
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储存条件:
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Store at RT
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溶解度:
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DMSO: ≤10 mM, soluble
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酸度系数(pKa):
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13.18±0.60(Predicted)
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形态:
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solid
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左色满卡林性质、用途与生产工艺
Levcromakalim ((-)-Cromakalim) 是 ATP 敏感性的 K+ 通道 (KATP) 激活剂。
Levcromakalim ((-)-Cromakalim) inhibits spontaneous contractions completely in a glibenclamide-sensitive manner. LevCromakalim (5 µM) inhibits spontaneous contractions, which are recovered by glibenclamide. Levcromakalim (1, 5 and 10 µM) inhibits phasic contractions to 34±21.1%, 20.1±20.0% and 0% of the control (n=5, respectively; P<0.05). Glibenclamide reverses the inhibition of spontaneous isometric contractions caused by LevCromakalim (5 µM) to 84±1.5% of the control (n=5; P<0.05). Levcromakalim (20 and 100 µM) also inhibits oxytocin (OXT) (10 nM)-induced phasic contractions to 34±21.4% and 14±12.6% of the control (n=6 and 4, respectively; P<0.05). Glibenclamide reverses the inhibition of spontaneous isometric contractions by LevCromakalim (100 µM) to 79±3.5% of the control (n=4; P<0.05). Tonic contraction by OXT is also suppressed by Cromakalim in a glibenclamide-sensitive manner.The function of the K
ATP
channels is examined with the specific channel opener LevCromakalim (Cromakalim). LevCromakalim induces dose-dependent relaxation in both the young and old mesenteric artery (MAs); and there is no difference in relaxation with age. However, the relaxation is markedly reduced in response to the high-salt (HS) diet in the old MAs (P<0.05). Maximum dilations to Levcromakalim (10
-4
M) are 97 ± 3% in the young MAs versus 98 ± 1% in the young salt arteries, while dilations are 99±0.7% in the old MAs when compared with 85 ± 5% in the old salt arteries (P<0.05).
左色满卡林
上下游产品信息
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下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-14255 | 左色满卡林
Levcromakalim | 94535-50-9 | 2 mg | 800元 |
| 2024/01/25 | HY-14255 | 左色满卡林
Levcromakalim | 94535-50-9 | 5mg | 1200元 |
左色满卡林
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左色满卡林国内生产厂家
94535-50-9, 左色满卡林 相关搜索:
- BioChemical
- Cell Biology
- Cell Signaling and Neuroscience
- Voltage-gated Ion Channels
- Potassium Channel Modulators
- Monovalent Ion Channels
- Ion Channels
- 左克罗卡林
- 左色满卡林
- 94535-50-9
- Potassium Channel,KcsA,Inhibitor,inhibit,BRL38227,BRL-38227,Levcromakalim
- 2H-1-Benzopyran-6-carbonitrile, 3,4-dihydro-3-hydroxy-2,2-dimethyl-4-(2-oxo-1-pyrrolidinyl)-, (3S,4R)-
- (3S,4R)-3-hydroxy-2,2-dimethyl-4-(2-oxopyrrolidin-1-yl)chroman-6-carbonitrile
- LevkroMakaliM
- Brn 3622889
- 2H-1-Benzopyran-6-carbonitrile, 3,4-dihydro-3-hydroxy-2,2-dimethyl-4-(2-oxo-1-pyrrolidinyl)-, (3S,trans)-
- (3β,4α)-3-Hydroxy-2,2-dimethyl-4-(2-oxopyrrolidin-1-yl)chroman-6-carbonitrile
- (3β,4α)-3,4-Dihydro-3-hydroxy-2,2-dimethyl-4-(2-oxopyrrolidin-1-yl)-2H-1-benzopyran-6-carbonitrile
- (3S,4R)-3β-Hydroxy-4-(2-oxopyrrolizino)-2,2-dimethyl-3,4-dihydro-6-cyano-2H-1-benzopyran
- levcromakelim
- lemakalim
- brl38227
- 2h-1-benzopyran-6-carbonitrile,3,4-dihydro-3-hydroxy-2,2-dimethyl-4-(2-oxo-1-p
- LEVCROMAKALIM
- (3s-trans)-yrrolidinyl)
- (3S,4R)-3,4-DIHYDRO-3-HYDROXY-2,2-DIMETHYL-4-(2-OXO-1-PYRROLIDINYL)-2H-1-BENZOPYRAN-6-CARBONITRILE