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LEVCROMAKALIM

LEVCROMAKALIM structure

CAS No.: 94535-50-9

Chemical Name:: LEVCROMAKALIM

Synonyms: brl38227;lemakalim;Brn 3622889;levcromakelim;LEVCROMAKALIM;LevkroMakaliM;(3s-trans)-yrrolidinyl);Potassium Channel,KcsA,Inhibitor,inhibit,BRL38227,BRL-38227,Levcromakalim;(3β,4α)-3-Hydroxy-2,2-dimethyl-4-(2-oxopyrrolidin-1-yl)chroman-6-carbonitrile;(3S,4R)-3-hydroxy-2,2-dimethyl-4-(2-oxopyrrolidin-1-yl)chroman-6-carbonitrile

CBNumber:: CB5104507

Molecular Formula:: C16H18N2O3

Molecular Weight:: 286.33

MDL Number:: MFCD00864806

MOL File:: 94535-50-9.mol

MSDS File:: SDS

Last updated:2023-09-20 16:43:00

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LEVCROMAKALIM Properties

Melting point	242-244°
alpha	D26 -52.2° (c = 1 in chloroform)
Boiling point	482.3±45.0 °C(Predicted)
Density	1.31±0.1 g/cm3(Predicted)
storage temp.	Store at RT
solubility	DMSO: ≤10 mM, soluble
pka	13.18±0.60(Predicted)
form	solid
FDA UNII	RW7PN4BLDJ

SAFETY

Risk and Safety Statements

Safety Statements	22-24/25
WGK Germany	3
RTECS	DJ2177500

LEVCROMAKALIM price More Price(10)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Tocris	1378	Levcromakalim ≥99%(HPLC)	94535-50-9	10	$259	2021-12-16	Buy
Tocris	1378	Levcromakalim ≥99%(HPLC)	94535-50-9	50	$1071	2021-12-16	Buy
TRC	L331300	Levcromakalim	94535-50-9	10mg	$185	2021-12-16	Buy
American Custom Chemicals Corporation	API0000895	LEVCROMAKALIM 95.00%	94535-50-9	10MG	$216.3	2021-12-16	Buy
ChemScene	CS-6950	Levcromakalim 99.79%	94535-50-9	5mg	$132	2021-12-16	Buy

Product number	Packaging	Price	Buy
1378	10	$259	Buy
1378	50	$1071	Buy
L331300	10mg	$185	Buy
API0000895	10MG	$216.3	Buy
CS-6950	5mg	$132	Buy

LEVCROMAKALIM Chemical Properties,Uses,Production

Uses

Anti-asthmatic; antihypertensive.

Uses

Levcromakalim is a potassium channel activator and vasorelaxant used in the management of hypertension in diabetes mellitus.

Definition

ChEBI: Levcromakalim is a 1-benzopyran.

Biological Activity

Active enantiomer of the prototypical K ATP channel opener cromakalim (trans-3,4-dihydro-3-hydroxy-2,2-dimethyl-4-(2-oxo-1-pyrrolidinyl)-2H-1-benzopyran-6-carbonitrile ). Hypotensive and airways relaxant. IC 50 = 490 nM in guinea pig trachea.

storage

Store at RT

LEVCROMAKALIM Preparation Products And Raw materials

Raw materials

Preparation Products

LEVCROMAKALIM Suppliers

Global( 51)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hangzhou FandaChem Co.,Ltd.	008657128800458; +8615858145714	fandachem@gmail.com	China	9348	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
Changzhou PBpharmaceutical R&D Co.,Ltd	0519-83990708	info@pbpharm.com	CHINA	498	58
TopScience Biochemical	00852-68527855	info@itopbiochem.com	China Hong Kong	902	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	+86-057181025280; +8617767106207	sales@molcore.com	China	49739	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	52927	58
3B Pharmachem (Wuhan) International Co.,Ltd.	821-50328103-801 18930552037	3bsc@sina.com	China	15848	69
MedChemexpress LLC	021-58955995	sales@medchemexpress.cn	United States	4863	58
EMMX Biotechnology LLC	888-539-0666	info@emmx.com	United States	8449	60
Changzhou PBpharmaceutical R&D Co.,Ltd	0519-83990708	lxy2046@yeah.net	China	480	55

Supplier	Advantage
Hangzhou FandaChem Co.,Ltd.	55
ATK CHEMICAL COMPANY LIMITED	60
Changzhou PBpharmaceutical R&D Co.,Ltd	58
TopScience Biochemical	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	58
Aladdin Scientific	58
3B Pharmachem (Wuhan) International Co.,Ltd.	69
MedChemexpress LLC	58
EMMX Biotechnology LLC	60
Changzhou PBpharmaceutical R&D Co.,Ltd	55

LEVCROMAKALIM Spectrum

LEVCROMAKALIM(94535-50-9)¹HNMR

94535-50-9(LEVCROMAKALIM)Related Search:

4-TERT-BUTOXYBENZONITRILE 3-(methylaminomethyl)benzonitrile LEVCROMAKALIM 3-M-TOLYL-DL-BETA-ALANINOL 3-CYANOBENZYLAMINE

(S)-3-Dimethylamino-3-phenylpropanol 1-Benzyl-2-pyrrolidinone CROMAKALIM (S)-3-(1-Aminoethyl)benzonitrile 4-(2-hydroxyethoxy)benzonitrile

2-(3-CYANO-PHENYL)ETHANOL (2S)-(-)-1-AMINO-3-PHENOXY-2-PROPANOL 4-isopropoxybenzonitrile 1-(3-HYDROXYPROPYL)-2-PYRROLIDONE 3-PYRROLIDINO-1,2-PROPANEDIOL

1-(3-METHOXYPROPYL)-2-PYRROLIDINONE 6-METHYL-CHROMAN-4-YLAMINE HYDROCHLORIDE 4-[3-(Dimethylamino)propoxy]benzonitrile

1of4

(3S,4R)-3,4-DIHYDRO-3-HYDROXY-2,2-DIMETHYL-4-(2-OXO-1-PYRROLIDINYL)-2H-1-BENZOPYRAN-6-CARBONITRILE (3s-trans)-yrrolidinyl) LEVCROMAKALIM 2h-1-benzopyran-6-carbonitrile,3,4-dihydro-3-hydroxy-2,2-dimethyl-4-(2-oxo-1-p brl38227 lemakalim levcromakelim (3S,4R)-3β-Hydroxy-4-(2-oxopyrrolizino)-2,2-dimethyl-3,4-dihydro-6-cyano-2H-1-benzopyran (3β,4α)-3,4-Dihydro-3-hydroxy-2,2-dimethyl-4-(2-oxopyrrolidin-1-yl)-2H-1-benzopyran-6-carbonitrile (3β,4α)-3-Hydroxy-2,2-dimethyl-4-(2-oxopyrrolidin-1-yl)chroman-6-carbonitrile 2H-1-Benzopyran-6-carbonitrile, 3,4-dihydro-3-hydroxy-2,2-dimethyl-4-(2-oxo-1-pyrrolidinyl)-, (3S,trans)- Brn 3622889 LevkroMakaliM (3S,4R)-3-hydroxy-2,2-dimethyl-4-(2-oxopyrrolidin-1-yl)chroman-6-carbonitrile 2H-1-Benzopyran-6-carbonitrile, 3,4-dihydro-3-hydroxy-2,2-dimethyl-4-(2-oxo-1-pyrrolidinyl)-, (3S,4R)- Potassium Channel,KcsA,Inhibitor,inhibit,BRL38227,BRL-38227,Levcromakalim 94535-50-9 Ion Channels Monovalent Ion Channels Potassium Channel Modulators Voltage-gated Ion Channels Cell Signaling and Neuroscience Cell Biology BioChemical