帕米膦酸
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- CAS号:
- 40391-99-9
- 英文名:
- Pamidronic acid
- 英文别名:
- DLV;AHPrBP;Panolin;amidronate;Rescriptor;Pamidronicaci;PAMIDRONIC ACID;Iflab-bb F1977-0047;Delavirdine mesylate;Ibandronate Impurity 23
- 中文名:
- 帕米膦酸
- 中文别名:
- 帕米膦酸;帕屈膦酸;伊班膦酸杂质5;帕米膦酸及帕米膦酸钠;(3-氨基-1-羟基亚丙基)双膦酸;3-氨基-1-羟基-1,1-丙烷二膦酸;3-氨基-1-羟基丙亚基-1,1-二磷酸;(3-氨基-1-羟基丙烷-1,1-二基)二膦酸
- CBNumber:
- CB8107554
- 分子式:
- C3H11NO7P2
- 分子量:
- 235.07
- MOL File:
- 40391-99-9.mol
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帕米膦酸化学性质
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熔点:
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226-228°C
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沸点:
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658.7±65.0 °C(Predicted)
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密度:
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1.998±0.06 g/cm3(Predicted)
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储存条件:
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under inert gas (nitrogen or Argon) at 2–8 °C
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溶解度:
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Methanol (Very Slightly, Heated, Sonicated), Water (Slightly, Heated, Sonicated)
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酸度系数(pKa):
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1.44±0.10(Predicted)
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形态:
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Solid
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颜色:
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Light Brown to Beige
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稳定性:
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Hygroscopic
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帕米膦酸性质、用途与生产工艺
Pamidronic acid 是用于研究各种骨吸收类疾病的药物。
Osteosarcoma cell viability decreases significantly in a concentration- and time-dependent manner at pamidronate concentrations ranging from 100 to 1000 μM, most consistently after 48 and 72 hours' exposure. In treated osteosarcoma cells, the lowest percentage cell viability is 34% (detected after 72 hours' exposure to 1000μM pamidronate). Pamidronate disodium inhibits Wnt and β-catenin signaling, which controls osteogenic differentiation in BMMSCs. Wnt3a, a Wnt and β-catenin signaling activator, reverses the negative effects caused by pamidronate disodium to salvage the osteogenic defect in BMMSCs.
Pamidronic acid can significantly inhibit and even reverse early osteoarthritic subchondral bone loss, thus alleviating the process of cartilaginous degeneration. The mechanisms involved may be associated with the upregulation of OPG expression, and downregulation of RANKL, MMP-9 and TLR-4 expression.
化学性质
结晶，熔点227~229℃。
帕米膦酸二钠(Pamidronate Disodium)：C3H9NO7P2Na2?5H2O。[57248-88-1]。失水温度从77.5℃到239.31℃，失水量为24．65%。
用途
二膦酸类骨吸收抑制剂。用于肿瘤高血钙症、佩吉特氏病、恶性肿瘤及正常血钙的骨质溶解性骨转移、特发性骨质疏松症。疗效显著，副作用低。
用途
用作帕米膦酸二钠中间体
生产方法
氯苯和β-氨基丙酸的水溶液加热至约100℃，搅拌下滴加三氯化磷，再保温反应。冷至室温，通氮气除去氯化氢气体。分出氯苯液，缓慢滴加水。搅拌升温至100℃反应。冷冻析晶，过滤，得帕米膦酸，收率68%，熔点227-229℃。
帕米膦酸悬浮于水，滴加30%氢氧化钠至Ph值7.2—7.4。-5-5℃冷置析晶，过滤。滤饼加适量蒸馏水，加热溶解，活性炭脱色，冷冻结晶，过滤，室温真空干燥至恒重，得帕米膦酸二钠五水合物，收率78.6%。
帕米膦酸
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-B0012 | Pamidronic acid | | 25 mg | 380元 |
| 2024/01/25 | HY-B0012 | 帕米膦酸
Pamidronic acid | 40391-99-9 | 10mM * 1mLin Water | 418元 |
帕米膦酸
生产厂家
全球有 116家供应商
帕米膦酸国内生产厂家
40391-99-9, 帕米膦酸 相关搜索:
- API
- Delavirdine
- (intermediate of pamidronate disodium)
- 医药原料
- 药物
- 其它药物
- C3H19NNa2O7P2
- C3H11NO7P2
- (3-氨基-1-羟基丙烷-1,1-二基)二膦酸
- 伊班膦酸杂质5
- 3-氨基-1-羟基-1,1-丙烷二膦酸
- 帕屈膦酸
- 帕米膦酸及帕米膦酸钠
- 3-氨基-1-羟基丙亚基-1,1-二磷酸
- (3-氨基-1-羟基亚丙基)双膦酸
- 帕米膦酸
- 40391-99-9
- (3-Amino-1-hydroxypropane-1,1-diyl)bis(phosphonic acid)
- Phosphonic acid, P,P'-(3-amino-1-hydroxypropylidene)bis-
- Pamidronic acid USP/EP/BP
- Pamidronicaci
- Pamidronic acid-d3 major
- Ibandronate Impurity 23
- (3-amino-1-hydroxypropane-1,1-diyl)diphosphonic acid
- PaMidronic acid(Delavirdine Mesylate,Rescriptor)
- Iflab-bb F1977-0047
- 1-Hydroxy-3-aminopropylidenebisphosphonic acid
- 1-Hydroxy-3-aminopropylidenebis(phosphonic acid)
- [2-Aminoethyl(hydroxy)methylene]bisphosphonic acid
- Propane-1-hydroxy-3-amino-1,1-diphosphonic acid
- Panolin
- 3-Amino-1-hydroxypropane-1,1-diphosphonic acid
- (3-Amino-1-hydroxypropylidene)-1,1-bisphosphonate
- AHPrBP
- Delavirdine mesylate
- 3-AMINO-1-HYDROXY-1,1-PROPANEDIPHOSPHONIC ACID
- (3-Amino-1-hydroxypropylidene)diphosphonic acid
- (3-amino-1-hydroxypropylidene)bisphosphonic acid
- DLV
- amidronate
- Rescriptor
- PAMIDRONIC ACID SODIUM SALT
- PAMIDRONIC ACID