帕米膦酸
中文名称 | 帕米膦酸 |
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中文同义词 | 帕米膦酸;(3-氨基-1-羟基亚丙基)双膦酸;3-氨基-1-羟基丙亚基-1,1-二磷酸;帕米膦酸及帕米膦酸钠;帕屈膦酸;3-氨基-1-羟基-1,1-丙烷二膦酸;伊班膦酸杂质5;(3-氨基-1-羟基丙烷-1,1-二基)二膦酸 |
英文名称 | Pamidronic acid |
英文同义词 | PAMIDRONIC ACID;PAMIDRONIC ACID SODIUM SALT;Rescriptor;amidronate;DLV;(3-amino-1-hydroxypropylidene)bisphosphonic acid;(3-Amino-1-hydroxypropylidene)diphosphonic acid;3-AMINO-1-HYDROXY-1,1-PROPANEDIPHOSPHONIC ACID |
CAS号 | 40391-99-9 |
分子式 | C3H11NO7P2 |
分子量 | 235.07 |
EINECS号 | 254-905-2 |
相关类别 | 其它药物;药物;医药原料;(intermediate of pamidronate disodium);Delavirdine;API |
Mol文件 | 40391-99-9.mol |
结构式 |
帕米膦酸 性质
熔点 | 226-228°C |
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沸点 | 658.7±65.0 °C(Predicted) |
密度 | 1.998±0.06 g/cm3(Predicted) |
储存条件 | under inert gas (nitrogen or Argon) at 2–8 °C |
溶解度 | 可溶于甲醇(轻微、加热、超声处理)、水(轻微、加热、超声处理) |
酸度系数(pKa) | 1.44±0.10(Predicted) |
形态 | 固体 |
颜色 | 浅棕色至米色 |
稳定性 | 吸湿性 |
Wnt, β-catenin
Osteosarcoma cell viability decreases significantly in a concentration- and time-dependent manner at pamidronate concentrations ranging from 100 to 1000 μM, most consistently after 48 and 72 hours' exposure. In treated osteosarcoma cells, the lowest percentage cell viability is 34% (detected after 72 hours' exposure to 1000μM pamidronate). Pamidronate disodium inhibits Wnt and β-catenin signaling, which controls osteogenic differentiation in BMMSCs. Wnt3a, a Wnt and β-catenin signaling activator, reverses the negative effects caused by pamidronate disodium to salvage the osteogenic defect in BMMSCs.
Pamidronic acid can significantly inhibit and even reverse early osteoarthritic subchondral bone loss, thus alleviating the process of cartilaginous degeneration. The mechanisms involved may be associated with the upregulation of OPG expression, and downregulation of RANKL, MMP-9 and TLR-4 expression.
帕米膦酸二钠(Pamidronate Disodium):C3H9NO7P2Na2?5H2O。[57248-88-1]。失水温度从77.5℃到239.31℃,失水量为24.65%。
帕米膦酸悬浮于水,滴加30%氢氧化钠至Ph值7.2—7.4。-5-5℃冷置析晶,过滤。滤饼加适量蒸馏水,加热溶解,活性炭脱色,冷冻结晶,过滤,室温真空干燥至恒重,得帕米膦酸二钠五水合物,收率78.6%。
安全信息
海关编码 | 9999999999 |
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提供商 | 语言 |
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英文
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更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/08/19 | HY-B0012 | Pamidronic acid | 25 mg | 380元 | |
2024/08/19 | HY-B0012 | 帕米膦酸 Pamidronic acid | 40391-99-9 | 10mM * 1mLin Water | 418元 |