双(麦芽醇)氧钒(IV)
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- CAS号:
- 38213-69-3
- 英文名:
- Bis(maltolato)oxovanadium(IV)
- 英文别名:
- BMOV;BIS(MALTOLATO)OXOVANADIUM;BIS(MALTOLATO)OXOVANADIUM(IV);oxovanadium(2+) bis(2-methyl-4-oxo-4H-pyran-3-olate);(SP-5-31)-Bis[3-(hydroxy-κO)-2-Methyl-4H-pyran-4-onato-κO4]oxovanadiuM;Vanadium,bis[3-(hydroxy-kO)-2-methyl-4H-pyran-4-onato-kO4]oxo-, (SP-5-31)-;Bis maltolato oxovanadium,Bis(maltolato)oxovanadium (IV),bis maltolato oxo vanadium;type-2,Phosphatase,inhibit,Bis(maltolato)oxovanadium(IV),SHP2,Inhibitor,phenotype,metabolic,SHP-1,HCPTPA,uptake,glucose,HPTPβ,insulin,PTP,PTP1B,diabetes
- 中文名:
- 双(麦芽醇)氧钒(IV)
- 中文别名:
- 双(麦芽醇)氧钒(IV)
- CBNumber:
- CB8113685
- 分子式:
- C12H10O7V
- 分子量:
- 317.15
- MOL File:
- 38213-69-3.mol
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双(麦芽醇)氧钒(IV)化学性质
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熔点:
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>300°C (dec.)
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储存条件:
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Refrigerator
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溶解度:
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DMSO (Slightly), Methanol (Slightly), Water (Slightly)
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形态:
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powder
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颜色:
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yellow to grey to brown
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LogP:
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0.079 (est)
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双(麦芽醇)氧钒(IV)性质、用途与生产工艺
BMOV (Bis maltolato oxovanadium, Bis(maltolato)oxovanadium (IV))是一种有效的口服钒复合物，具有抗糖尿病特性和模仿胰岛素的作用。BMOV被证明可改善糖尿病模型的心脏功能障碍。
IC50: 126 nM (HCPTPA), 109 nM (PTP1B), 26 nM (HPTPβ) and 201 nM (SHP2)
Bis(maltolato)oxovanadium(IV) treatment enhances the phosphorylation of the insulin receptor and of the insulin signalling key intermediate Akt. Bis(maltolato)oxovanadium(IV) (BMOV; 50 μM) treatment also resultes in an increased glucose uptake in C2C12 cells.
Bis(maltolato)oxovanadium(IV) (BMOV; 0.75-3.0 mmol; intraperitoneal injection; twice weekly; for 6 weeks; C57BL/6J mice) treatment ameliorates the metabolic phenotype. Liver, skeletal muscle, and adipose tissue revealed a significantly reduced PTP activity in all analysed tissues compared to HFD mice.
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Animal Model:
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C57BL/6J mice (4-6 weeks) fed with high-fat diet (HFD)
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Dosage:
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0.75-3.0 mmol
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Administration:
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Intraperitoneal injection; twice weekly; for 6 weeks
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Result:
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Ameliorated the metabolic phenotype, as evidenced by reduced body weight, improved insulin sensitivity and glucose tolerance.
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双(麦芽醇)氧钒(IV)
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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| 2024/04/30 | HY-118567 | Bis(maltolato)oxovanadium(IV) | | 5 mg | 400元 |
| 2024/04/30 | HY-118567 | Bis(maltolato)oxovanadium(IV) | | 10 mM * 1 mLin DMSO | 440元 |
38213-69-3, 双(麦芽醇)氧钒(IV) 相关搜索:
- Pharmaceuticals
- Intermediates & Fine Chemicals
- Heterocycles
- 药靶配体
- 营养强化剂
- 工业化工类
- C12H10O7V
- 双(麦芽醇)氧钒(IV)
- 38213-69-3
- type-2,Phosphatase,inhibit,Bis(maltolato)oxovanadium(IV),SHP2,Inhibitor,phenotype,metabolic,SHP-1,HCPTPA,uptake,glucose,HPTPβ,insulin,PTP,PTP1B,diabetes
- Bis maltolato oxovanadium,Bis(maltolato)oxovanadium (IV),bis maltolato oxo vanadium
- Vanadium,bis[3-(hydroxy-kO)-2-methyl-4H-pyran-4-onato-kO4]oxo-, (SP-5-31)-
- oxovanadium(2+) bis(2-methyl-4-oxo-4H-pyran-3-olate)
- (SP-5-31)-Bis[3-(hydroxy-κO)-2-Methyl-4H-pyran-4-onato-κO4]oxovanadiuM
- BIS(MALTOLATO)OXOVANADIUM
- BIS(MALTOLATO)OXOVANADIUM(IV)
- BMOV