双(麦芽醇)氧钒(IV)
| 中文名称 | 双(麦芽醇)氧钒(IV) |
|---|---|
| 中文同义词 | 双(麦芽醇)氧钒(IV) |
| 英文名称 | Bis(maltolato)oxovanadium(IV) |
| 英文同义词 | BMOV;BIS(MALTOLATO)OXOVANADIUM(IV);BIS(MALTOLATO)OXOVANADIUM;(SP-5-31)-Bis[3-(hydroxy-κO)-2-Methyl-4H-pyran-4-onato-κO4]oxovanadiuM;oxovanadium(2+) bis(2-methyl-4-oxo-4H-pyran-3-olate);Vanadium,bis[3-(hydroxy-kO)-2-methyl-4H-pyran-4-onato-kO4]oxo-, (SP-5-31)-;Bis maltolato oxovanadium,Bis(maltolato)oxovanadium (IV),bis maltolato oxo vanadium;type-2,Phosphatase,inhibit,Bis(maltolato)oxovanadium(IV),SHP2,Inhibitor,phenotype,metabolic,SHP-1,HCPTPA,uptake,glucose,HPTPβ,insulin,PTP,PTP1B,diabetes |
| CAS号 | 38213-69-3 |
| 分子式 | C12H10O7V |
| 分子量 | 317.15 |
| EINECS号 | |
| 相关类别 | 工业化工类;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals |
| Mol文件 | 38213-69-3.mol |
| 结构式 |  |
双(麦芽醇)氧钒(IV) 性质
| 熔点 | >300°C (dec.) |
|---|---|
| 储存条件 | Refrigerator |
| 溶解度 | DMSO（少许）、甲醇（少许）、水（少许） |
| 形态 | 粉末 |
| 颜色 | 黄色到灰色到棕色 |
| LogP | 0.079 (est) |
BMOV (Bis maltolato oxovanadium, Bis(maltolato)oxovanadium (IV))是一种有效的口服钒复合物，具有抗糖尿病特性和模仿胰岛素的作用。BMOV被证明可改善糖尿病模型的心脏功能障碍。
IC50: 126 nM (HCPTPA), 109 nM (PTP1B), 26 nM (HPTPβ) and 201 nM (SHP2)
Bis(maltolato)oxovanadium(IV) treatment enhances the phosphorylation of the insulin receptor and of the insulin signalling key intermediate Akt. Bis(maltolato)oxovanadium(IV) (BMOV; 50 μM) treatment also resultes in an increased glucose uptake in C2C12 cells.
Bis(maltolato)oxovanadium(IV) (BMOV; 0.75-3.0 mmol; intraperitoneal injection; twice weekly; for 6 weeks; C57BL/6J mice) treatment ameliorates the metabolic phenotype. Liver, skeletal muscle, and adipose tissue revealed a significantly reduced PTP activity in all analysed tissues compared to HFD mice.
| Animal Model: | C57BL/6J mice (4-6 weeks) fed with high-fat diet (HFD) |
| Dosage: | 0.75-3.0 mmol |
| Administration: | Intraperitoneal injection; twice weekly; for 6 weeks |
| Result: | Ameliorated the metabolic phenotype, as evidenced by reduced body weight, improved insulin sensitivity and glucose tolerance. |
安全信息
| 危险品运输编号 | UN 2811 6.1 / PGIII |
|---|---|
| WGK Germany | 3 |