奎寧定鹽酸鹽
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- CAS号:
- 6151-40-2
- 英文名:
- QUINIDINE HYDROCHLORIDE
- 英文别名:
- QUINIDINE HYDROCHLORIDE;QUINIDINE HYDROCHLORIDE MONOHYDRATE;Quinidine monohydrate hydrochloride;Quinidine monohydrochloride monohydrate;QUINIDINE HYDROCHLORIDE ISO 9001：2015 REACH;QUINIDINE HYDROCHLORIDE MONOHYDRATE CRYSTALLINE;6μ-Methoxycinchonan-9-ol hydrochloride monohydrate;Quinidine hydrochloride monohydrate technical grade;Cinchonan-9-ol,6'-methoxy-, monohydrochloride, monohydrate, (9S)- (9CI);Potassium Channel,KcsA,Quinidine hydrochloride monohydrate,Inhibitor,Parasite,inhibit
- 中文名:
- 奎寧定鹽酸鹽
- 中文别名:
- 奎尼丁盐酸盐;奎寧定鹽酸鹽;盐酸奎尼丁一水合物;奎尼丁单盐酸盐一水合物;奎尼丁 盐酸盐 一水合物
- CBNumber:
- CB9171297
- 分子式:
- C20H27ClN2O3
- 分子量:
- 378.9
- MOL File:
- 6151-40-2.mol
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奎寧定鹽酸鹽化学性质
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熔点:
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258-259 C
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储存条件:
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Store at -20°C
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溶解度:
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DMSO: 100 mg/mL (263.93 mM); Water: 2.5 mg/mL (6.60 mM)
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奎寧定鹽酸鹽性质、用途与生产工艺
Quinidine hydrochloride monohydrate 是一种抗心律失常剂，也是 K+ 通道 (K+ channel) 的有效阻断剂，其 IC50 值为 19.9 μM。Quinidine hydrochloride monohydrate 是一种有效且选择性的细胞色素 P450db (cytochrome P450db) 抑制剂，也可用作疟疾的研究。
IC50: 19.9 μM (K
+
channel)
Quinidine hydrochloride monohydrate blocks WT mSlo3 (K
Ca
5.1) channels with an IC
50
of 19.9±1.41 μM and Hill slope of 1.15±0.15 (n=7). Again, the potency of inhibition by Quinidine hydrochloride monohydrate is higher for F304Y mSlo3 (IC
50
of 2.42±0.60 μM, n=9, P<0.005; Hill slope of 0.98±0.12), but lower with R196Q mSlo3 (IC
50
of 38.4±6.77 μM, n=5, P<0.001; Hill slope of 1.05±0.16). The inhibition of F304Y mSlo3 by Quinidine hydrochloride monohydrate is observed to have some time dependence.
Direct application of Quinidine hydrochloride monohydrate on the sciatic nerve produces a dose-related decrease in amplitude at ascending somato-sensory evoked potential (SSEP) and descending compound muscle action potentials (CMAP) when comparing baseline with other time points, or when comparing the experimental left limb to the right contra-lateral glucose-treated limb. The latencies of SSEPs and CMAP potentials after Quinidine hydrochloride monohydrate applications are increased compare to baseline and the contralateral side.
奎寧定鹽酸鹽
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-B1302 | 奎寧定鹽酸鹽
Quinidine hydrochloride monohydrate | 6151-40-2 | 100mg | 500元 |
| 2024/01/25 | HY-B1302 | 奎寧定鹽酸鹽
Quinidine hydrochloride monohydrate | 6151-40-2 | 10mM * 1mLin DMSO | 550元 |
奎寧定鹽酸鹽
生产厂家
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奎寧定鹽酸鹽国内生产厂家
6151-40-2, 奎寧定鹽酸鹽 相关搜索:
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- Inhibitors
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- Inhibitors
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- Xenobiotics and Drug Metabolism
- C20H24N2O2HClH2O
- 盐酸奎尼丁一水合物
- 奎尼丁 盐酸盐 一水合物
- 奎尼丁单盐酸盐一水合物
- 奎尼丁盐酸盐
- 奎寧定鹽酸鹽
- 6151-40-2
- Cinchonan-9-ol,6'-methoxy-, monohydrochloride, monohydrate, (9S)- (9CI)
- Potassium Channel,KcsA,Quinidine hydrochloride monohydrate,Inhibitor,Parasite,inhibit
- QUINIDINE HYDROCHLORIDE ISO 9001：2015 REACH
- 6μ-Methoxycinchonan-9-ol hydrochloride monohydrate
- Quinidine monohydrochloride monohydrate
- Quinidine monohydrate hydrochloride
- QUINIDINE HYDROCHLORIDE MONOHYDRATE CRYSTALLINE
- QUINIDINE HYDROCHLORIDE MONOHYDRATE
- QUINIDINE HYDROCHLORIDE
- Quinidine hydrochloride monohydrate technical grade