Botiacrine

Botiacrine Struktur
4774-53-2
CAS-Nr.
4774-53-2
Englisch Name:
Botiacrine
Synonyma:
Botiacrine;10-[2-(Dimethylamino)ethylthiocarbonyl]-9,9-dimethylacridan;S-(2-dimethylaminoethyl) 9,9-dimethylacridine-10-carbothioate;9,9-dimethylacridine-10-carbothioic acid S-(2-dimethylaminoethyl) ester;10(9H)-Acridinecarbothioic acid, 9,9-dimethyl-, S-[2-(dimethylamino)ethyl] ester
CBNumber:
CB01178137
Summenformel:
C20H24N2OS
Molgewicht:
340.48
MOL-Datei:
4774-53-2.mol

Botiacrine Eigenschaften

Siedepunkt:
450.2±55.0 °C(Predicted)
Dichte
1.144±0.06 g/cm3(Predicted)
pka
8.46±0.28(Predicted)

Sicherheit

Botiacrine Chemische Eigenschaften,Einsatz,Produktion Methoden

Originator

Botiacrine,ZYF Pharm Chemical

Manufacturing Process

To 1 gramm-equivalent (g-eq) of dimethylaminoethanethiol in 150 ml of ether, a suspension of g-eq of 50% sodium hydride in 50-ml of anhydrous ether was added. After boiling for 1 hour, the reaction mixture was cooled to 0°C, whereupon g-eq of 9,9-dimethylacridan-10-carboxylic acid chloride (prepared from 9,9-dimethylacridan and phosghene - cf. Swiss Specification No. 426,821) were added and the mixture was heated for a further 6 hours to boiling temperature. After cooling to ambient temperature, the precipitated sodium chloride was filtered in a Buchner funnel fitted with a filter cell. The corresponding 9,9-dimethylacridan-10-carboxylic aciddimethylaminoethanethiol ester was immediately precipitated out of filtrate as base, which melted at 110.5°-111°C. Ethanesulphonic acid salt melted at 147°-150°C.

Therapeutic Function

Antiparkinsonian

Botiacrine Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


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  • 9,9-dimethylacridine-10-carbothioic acid S-(2-dimethylaminoethyl) ester
  • S-(2-dimethylaminoethyl) 9,9-dimethylacridine-10-carbothioate
  • Botiacrine
  • 10-[2-(Dimethylamino)ethylthiocarbonyl]-9,9-dimethylacridan
  • 10(9H)-Acridinecarbothioic acid, 9,9-dimethyl-, S-[2-(dimethylamino)ethyl] ester
  • 4774-53-2
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