Botiacrine
- CAS No.
- 4774-53-2
- Chemical Name:
- Botiacrine
- Synonyms
- Botiacrine;10-[2-(Dimethylamino)ethylthiocarbonyl]-9,9-dimethylacridan;S-(2-dimethylaminoethyl) 9,9-dimethylacridine-10-carbothioate;9,9-dimethylacridine-10-carbothioic acid S-(2-dimethylaminoethyl) ester;10(9H)-Acridinecarbothioic acid, 9,9-dimethyl-, S-[2-(dimethylamino)ethyl] ester
- CBNumber:
- CB01178137
- Molecular Formula:
- C20H24N2OS
- Molecular Weight:
- 340.48
- MDL Number:
- MOL File:
- 4774-53-2.mol
| Boiling point | 450.2±55.0 °C(Predicted) |
|---|---|
| Density | 1.144±0.06 g/cm3(Predicted) |
| pka | 8.46±0.28(Predicted) |
| FDA UNII | 032WJR708Q |
Botiacrine Chemical Properties,Uses,Production
Originator
Botiacrine,ZYF Pharm Chemical
Manufacturing Process
To 1 gramm-equivalent (g-eq) of dimethylaminoethanethiol in 150 ml of ether, a suspension of g-eq of 50% sodium hydride in 50-ml of anhydrous ether was added. After boiling for 1 hour, the reaction mixture was cooled to 0°C, whereupon g-eq of 9,9-dimethylacridan-10-carboxylic acid chloride (prepared from 9,9-dimethylacridan and phosghene - cf. Swiss Specification No. 426,821) were added and the mixture was heated for a further 6 hours to boiling temperature. After cooling to ambient temperature, the precipitated sodium chloride was filtered in a Buchner funnel fitted with a filter cell. The corresponding 9,9-dimethylacridan-10-carboxylic aciddimethylaminoethanethiol ester was immediately precipitated out of filtrate as base, which melted at 110.5°-111°C. Ethanesulphonic acid salt melted at 147°-150°C.
Therapeutic Function
Antiparkinsonian
Botiacrine Preparation Products And Raw materials
Botiacrine Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
| Supplier | Advantage |
|---|---|
| Hangzhou MolCore BioPharmatech Co.,Ltd. | 58 |