Paricalcitol
|
|
|
- CAS-Nr.
- 131918-61-1
- Englisch Name:
- Paricalcitol
- Synonyma:
- Zemplar;CS-1390;Zemplarr;PARICALCITOL;Paricalciferol;Paricalcitol, >=98%;Paricalcitol(Zemplar);19-Nor-1,25-
dihydroxyvitaMin D2;1α,25-Dihydroxy-19-nor-vitaMin D2;19-nor-1alpha,25-dihydroxyvitamin D2
- CBNumber:
- CB0500520
- Summenformel:
- C27H44O3
- Molgewicht:
- 416.65
- MOL-Datei:
- 131918-61-1.mol
|
Paricalcitol Eigenschaften
- Siedepunkt:
- 564.8±50.0 °C(Predicted)
- Dichte
- 1.121±0.06 g/cm3(Predicted)
- Flammpunkt:
- 14℃
- storage temp.
- Store at -20°C,unstable in solution, ready to use.
- Löslichkeit
- DMSO : 100 mg/mL (240.02 mM; Need ultrasonic)Ethanol : 12.5 mg/mL (30.00 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble)
- pka
- 14.34±0.40(Predicted)
- InChIKey
- BPKAHTKRCLCHEA-UBFJEZKGSA-N
- SMILES
- C[C@]12CCC/C(=C\C=C3C[C@@H](O)C[C@H](O)C3)/[C@]1([H])CC[C@]2([H])[C@H](C)/C=C/[C@H](C)C(O)(C)C |&1:1,10,13,16,20,22,26,r|
- CAS Datenbank
- 131918-61-1(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
 
|
| Alarmwort |
Achtung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H330 |
Lebensgefahr bei Einatmen. |
Akute Toxizität inhalativ |
Kategorie 1 |
Achtung |
![GHS hazard pictograms]() src="/GHS06.jpg" width="20" height="20" /> |
P260, P271, P284, P304+P340, P310,P320, P403+P233, P405, P501 |
| H372 |
Schädigt bei Hautkontakt und Verschlucken die Organe bei längerer oder wiederholter Exposition. |
Spezifische Zielorgan-Toxizität (wiederholte Exposition) |
Kategorie 1 |
Achtung |
![GHS hazard pictograms]() src="/GHS08.jpg" width="20" height="20" /> |
P260, P264, P270, P314, P501 |
|
| Sicherheit |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P314 |
Bei Unwohlsein ärztlichen Rat einholen / ärztliche Hilfe hinzuziehen. |
|
Paricalcitol Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Paricalcitol was launched as Zemplar in the US for the prevention and
treatment of secondary hyperthyroidism associated with chronic renal failure.
Paricalcitol is a synthetic vitamin D2, namely a novel 1-alpha-hydroxy-19-noranalogue
in which the ring A exocyclic methylene group, typical of all vitamin D
systems, has been replaced by two hydrogen atoms. Paricalcitol is the first
vitamin D analogue marketed for this indication. In patients with chronic renal
failure, Paricalcitol appreciably reduced levels of parathyroid hormone (PTH)
without a significant difference in the incidence rate for hypercalcemia or
hyperphosphatemia when compared with placebo.
Chemische Eigenschaften
White Solid
Verwenden
1,25-Dihydroxy vitamin D2 is a potent agonist of the vitamin D receptor. Paricalcitol is a synthetic 1,25-dihydroxy vitamin D2 analog. As vitamin D deficiency, associated with chronic kidney disease, leads to an increase in parathyroid hormone (secondary hyperparathyroidism), paricalcitol is used in renal patients to block parathyroid hormone overproduction. Vitamin D deficiency is also a risk factor in cancer, cardiovascular disease, hypertension, and diabetes, and paricalcitol may have applications in those contexts as well.
Paricalcitol Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Paricalcitol Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 257)Lieferanten
131918-61-1()Verwandte Suche:
- 1α,25-Dihydroxy-19-nor-vitaMin D2
- Paricalcitol/ 19-nor-1α,25-dihydroxyergocalciferol
- PARICALCITOL (10 MG)F0E3030.997MG/MG(AI)
- PARICALCITOL
- 19-nor-1alpha,25-dihydroxyvitamin D2
- (1R,3R)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(E,2R,5S)-6-Hydroxy-5,6-dimethylhept-3-en-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]cyclohexane-1,3-diol
- 1,3-Cyclohexanediol, 5-[(2E)-2-[(1R,3aS,7aR)-octahydro-1-[(1R,2E,4S)-5-hydroxy-1,4,5-trimethyl-2-hexen-1-yl]-7a-methyl-4H-inden-4-ylidene]ethylidene]-, (1R,3R,5Z)-
- Paricalcitol, >=98%
- 1,25-DihydroxyvitaMin D2
Paricalcitol
- Paricalcitol(Zemplar)
- Paricalcitol (10 mg) (COLD SHIPMENT REQUIRED)
- (1R,3R,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-Octahydro-1-[(1R,2E,4S)-5-hydroxy-1,4,5-triMethyl-2-hexen-1-yl]-7a-Methyl-4H-inden-4-ylidene]ethylidene]-1,3-cyclohexanediol
- (1α,3β,7E,22E)-19-Nor-9,10-secoergosta-5,7,22-triene-1,3,25-triol
- 19-Nor-1,25-
dihydroxyvitaMin D2
- (1R,3R)-5-(2-((1R,3aS,7aR,E)-1-((2R,5S,E)-6-hydroxy-5,6-dimethylhept-3-en-2-yl)-7a-methyloctahydro-4H-inden-4-ylidene)ethylidene)cyclohexane-1,3-diol
- ParicalcitolQ: What is
Paricalcitol Q: What is the CAS Number of
Paricalcitol Q: What is the storage condition of
Paricalcitol Q: What are the applications of
Paricalcitol
- Paricalcitol (COLD SHIPMENT REQUIRED) (1499403)
- CS-1390
- Zemplar
- (1R,3R)-5-((E)-2-((1R,3aS,7aR)-1-((2R,5S,E)-6-Hydroxy-5,6-dimethylhept-3-en-2-yl)-7a-methylhexahydro-1H-inden-4(2H)-ylidene)ethylidene)cyclohexane-1,3-diol
- Paricalciferol
- Zemplarr
- 131918-61-1
- 131919-61-1
- Vitamin D3 analogs
- Chiral Reagents
- Intermediates & Fine Chemicals
- Pharmaceuticals
- 131918-61-1
