Propafenone Hydrochloride
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- CAS-Nr.
- 34183-22-7
- Bezeichnung:
- Propafenone Hydrochloride
- Englisch Name:
- Propafenone Hydrochloride
- Synonyma:
- PROPAFENONE HCL;Pronon;Rythmol;rytmonorm;SA-79 (hydrochloride);1-Propanone, 1-[2-[2-hydroxy-3-(propylamino)propoxy]phenyl]-3-phenyl-, hydrochloride (9CI);sa79;wz884;Ropaful;Sobiral
- CBNumber:
- CB1311105
- Summenformel:
- C21H28ClNO3
- Molgewicht:
- 377.9
- MOL-Datei:
- 34183-22-7.mol
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Propafenone Hydrochloride Eigenschaften
- Schmelzpunkt:
- 165-1670C
- storage temp.
- 2-8°C
- Löslichkeit
- Slightly soluble in cold water, soluble in methanol and in hot water, practically insoluble in ethanol (96 per cent).
- Farbe
- White to Off-White
- maximale Wellenlänge (λmax)
- 303nm(MeOH)(lit.)
- Merck
- 14,7794
- CAS Datenbank
- 34183-22-7(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| Kennzeichnung gefährlicher |
T,Xn |
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| R-Sätze: |
46-22 |
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| S-Sätze: |
53-36/37/39-45 |
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| WGK Germany |
3 |
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| RTECS-Nr. |
UH2833000 |
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| HS Code |
2922504500 |
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| Toxizität |
LD50 in rats (mg/kg): 18.8 i.v.; 700 orally (Hapke, Prigge) |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitsschädlich bei Verschlucken. |
Akute Toxizität oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
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| Sicherheit |
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Propafenone Hydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden
R-Sätze Betriebsanweisung:
R46:Kann vererbbare Schäden verursachen.
R22:Gesundheitsschädlich beim Verschlucken.
S-Sätze Betriebsanweisung:
S53:Exposition vermeiden - vor Gebrauch besondere Anweisungen einholen.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
Beschreibung
Propafenone hydrochloride is a class I anti-arrhythmic agent with basic local anaesthetic and membrane-stabilizing properties. Some P-adrenergic blocking action has also been described. Propafenone decreases the depolarization velocity and slows conduction in the His-Purkinje system with resultant increase in the PR interval and the QRS complex. Propafenone is used in the treatment of paroxysmal supraventricular tachycardias and ventricular arrhythmias.
Propafenone should not be used in uncontrolled cardiac failure, severe obstructive pulmonary disease or marked hypotension. Propafenone may worsen myasthenia gravis.
Chemische Eigenschaften
White Solid
Verwenden
Propafenone hydrochloride is a class IC antiarrhythmic agent used for the management of severe ventricular and supraventricular arrhythmias. It has beta-blocking and weak calcium channel blocking properties, as well as some negative inotropic activity. Propafenone is in a class of medications called antiarrhythmics. It works by acting on the heart muscle to improve the heart's rhythm.
Verwenden
Sodium channel blocker. Antiarrhythmic (class IC)
Definition
ChEBI: Propafenone hydrochloride is a hydrochloride that is the monohydrochloride salt of propafenone. It is a class 1C antiarrhythmic drug with local anesthetic effects, and is used in the management of supraventricular and ventricular arrhythmias. It has a role as an anti-arrhythmia drug. It contains a propafenone(1+).
Pharmakokinetik
Propafenone hydrochloride (Rythmol(R)) is similar in action to flecainide. It reduces the fast inward sodium current in Purkinje fibres and to a lesser extent in myocardial fibres. Unlike other class l drugs, propafenone has mild B-blocking effects. This may contribute to its overall effects on the conduction system. lt is also believed to have calcium channel-blocking effects, which may contribute to its mild negative inotropic effects.
Propafenone Hydrochloride Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Propafenone Hydrochloride Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 361)Lieferanten
34183-22-7(Propafenone Hydrochloride)Verwandte Suche:
- 1-[2-(2-HYDROXY-3-[PROPYLAMINO]-PROPOXY)PHENYL]-3-PHENYL-1-PROPANONE HYDROCHLORIDE
- 1-[2-[2-hydroxy-3-(propylamino)propoxy]phenyl]-3-phenylpropan-1-one hydrochloride
- sa79
- wz884
- Arythmol
- Rytmonor
- Propiophenone, 2'-[2-hydroxy-3-(propylamino)propoxy]-3-phenyl-, hydrochloride (8CI)
- 1-(2-(2-hydroxy-3-(propylamino)propoxy)phenyl)-3-phenyl-1-propanonhydroc
- 2’-(2-hydroxy-3-(propylamino)propoxy)-3-phenylpropiophenonehydrochloride
- 2’-(2-hydroxy-3-(propylamino)propoxy)-3-phenyl-propiophenonhydrochloride
- baxarytmon
- fenoprain
- propafenonhydrochlorid
- rhythmonorm
- Ropaful
- Sobiral
- 1-(2-(2-Hydroxy-3-(Propylamino)Propoxy)Phenyl)-3
- Propatenone Hydrochloride Reference Standard
- Propafenone hydrochloride,1-[2-(2-Hydroxy-3-(propylamino)propoxy)phenyl]-3-phenyl-1-propanone hydrochloride
- Propafenone Hydrochloride (200 mg)
- 1-Propanone,1-[2-[2-hydroxy-3-(propylaMino)propoxy]phenyl]-3-phenyl-
- (±)-Propafenone-d7 HCl
- Puluo Pa ketone hydrochloride
- 1-Propanone, 1-[2-[2-hydroxy-3-(propylamino)propoxy]phenyl]-3-phenyl-, hydrochloride (1:1)
- Rythmol hydrochloride
- Rythmol SR hydrochloride
- Rytmonorm hydrochloride
- PROPAFENONE HYDROCHLORIDE
- Propafenone Impurity 9
- Propafenone hydrochloride salt
- PropafenoneHydrochloride>
- Propafenone hydrochloride CRS
- Propafenone hydrochL
- Propafenone Hydrochloride USP/EP/BP
- 1-[2-[2-hydroxy-3-(propylamino)propoxy]phenyl]-3-phenylpropan-1-one hydrochloride USP/EP/BP
- Propafenone HCl (SA-79)
- Propafenone HydrochlorideQ: What is
Propafenone Hydrochloride Q: What is the CAS Number of
Propafenone Hydrochloride Q: What is the storage condition of
Propafenone Hydrochloride Q: What are the applications of
Propafenone Hydrochloride
- Propafenone Hydrochloride API
- Propafenone Hydrochloride (1570304)
- PROPAFENONE HCL
- rytmonorm
- Pronon
- Rythmol
- 1-Propanone, 1-[2-[2-hydroxy-3-(propylamino)propoxy]phenyl]-3-phenyl-, hydrochloride (9CI)
- SA-79 (hydrochloride)
- 34183-22-7
- C21H27NO3xHCl
- C21H27NO3HCl
- C21H28ClNO3
- C21H27NO3HClC21H28ClNO3
- C21H27NO3ClH
- Inhibitors
- Amines
- Aromatics
- Sodium channel
- Intermediates & Fine Chemicals
- Pharmaceuticals
- 34183-22-7
