JAK2 Inhibitor III, SD-1029

118372-34-2

CAS-Nr.: 118372-34-2

Englisch Name:: JAK2 Inhibitor III, SD-1029

Synonyma:: SD 1029;NSC371488;NSC-371488;NSC 371488;JAK2 Inhibitor III, SD-1029;9-(3,4-dichlorophenyl)-2,7-bis[(dimethylamino)methyl]-3,4,5,6,7,9-hexahydro-1H-xanthene-1,8(2H)-dione,dihydrobromide

CBNumber:: CB13136754

Summenformel:: C25H32Br2Cl2N2O3

Molgewicht:: 639.24718

MOL-Datei:: 118372-34-2.mol

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Eigenschaften Sicherheit Verwendungswort Produktionsfirma 12

JAK2 Inhibitor III, SD-1029 Eigenschaften

storage temp.: Store at -20°C

Löslichkeit: DMSO: 10 mg/ml

Aggregatzustand: A solid

Sicherheit

JAK2 Inhibitor III, SD-1029 Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

SD-1029 is a Janus kinase 2 (JAK2) inhibitor. It inhibits autophosphorylation of recombinant JAK2 when used at concentrations of 30 and 100 μM and decreases levels of phosphorylated JAK2, but not JAK1 or Src, in MDA-MB-468 and paclitaxel-resistant OVCAR8_TR cells when used at a concentration of 10 μM. SD-1029 (10 μM) decreases levels of phosphorylated STAT3 in MDA-MB-468, MDA-BM-435, OVCAR8_TR, and SKOV3_TR cells and inhibits IL-6-induced nuclear translocation of STAT3 in BHK-21 and U2OS cells. It decreases the viability of and increases levels of cleaved caspase-3 in SNU-387, SNU-398, HepG2, and Huh7 hepatocellular carcinoma cells when used at a concentration of 10 μM. SD-1029 (100 and 1,000 nM) inhibits hepatitis A virus replication in GL37 cells.

JAK2 Inhibitor III, SD-1029 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

JAK2 Inhibitor III, SD-1029 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 12)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6313	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	52927	58
Shanghai Hongye Biotechnology Co. Ltd	400-9205774	sales@glpbio.cn	China	6870	58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	18818260767	sales@chemegen.com	China	11289	58
TargetMol Chemicals Inc.	4008200310	marketing@tsbiochem.com	China	24017	58
Nanjing Tengyi Biotechnology Co., Ltd	025-58851786 17714337195	sales@tybiochem.com	China	5141	58
Shanghai Yifei Biotechnology Co. , Ltd.	021-65675885 18964387627	customer_service@efebio.com	China	8740	58
Nanjing Shizhou Biology Technology Co.,Ltd	025-85560043 15850508050	cindy.huang@synzest.com	China	12007	58

JAK2 Inhibitor III, SD-1029
SD 1029
NSC 371488
NSC371488
NSC-371488
9-(3,4-dichlorophenyl)-2,7-bis[(dimethylamino)methyl]-3,4,5,6,7,9-hexahydro-1H-xanthene-1,8(2H)-dione,dihydrobromide
118372-34-2