SB 225002
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- CAS-Nr.
- 182498-32-4
- Englisch Name:
- SB 225002
- Synonyma:
- SB 225002;SB-225002;SB 225002;SB 225002 USP/EP/BP;SB225002 182498-32-4;SB 225002 - CAS 182498-32-4 - Calbiochem;1-(2-bromophenyl)-3-(2-hydroxy-4-nitrophenyl)urea;N-(2-BROMOPHENYL)-N'-(2-HYDROXY-4-NITROPHENYL)UREA;N-(2-HYDROXY-4-NITROPHENYL)-N'-(2-BROMOPHENYL)UREA;Urea, N-(2-bromophenyl)-N'-(2-hydroxy-4-nitrophenyl)-
- CBNumber:
- CB1455331
- Summenformel:
- C13H10BrN3O4
- Molgewicht:
- 352.14
- MOL-Datei:
- 182498-32-4.mol
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SB 225002 Eigenschaften
- Siedepunkt:
- 401.6±45.0 °C(Predicted)
- Dichte
- 1.793±0.06 g/cm3(Predicted)
- storage temp.
- room temp
- Löslichkeit
- Soluble to 100mM in DMSO and to 50mM in ethanol
- Aggregatzustand
- Yellow solid
- pka
- 5.29±0.10(Predicted)
- Farbe
- white to beige
- Sensitive
- Moisture Sensitive
- Stabilität:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
- InChIKey
- MQBZVUNNWUIPMK-UHFFFAOYSA-N
- CAS Datenbank
- 182498-32-4
SB 225002 Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
CXCR2 (IL-
8RB) is a seven-
transmembrane G protein-
coupled receptor whose physiological ligands include IL-
8 (CXCL8) and growth related oncogene α (Gro-
α; CXCL1). IL-
8 and Gro-
α are pro-
inflammatory CXC chemokines that act as chemoattractants, especially for neutrophils, and promote angiogenesis. SB 225002 is a selective non-
peptide inhibitor of CXCR2, inhibiting IL-
8 binding to CXCR2 with an IC
50 value of 22 nM. SB225002 inhibits neutrophil chemotaxis in response to IL-
8
in vitro (IC
50 = 20 nM) and blocks neutrophil margination induced by IL-
8
in vivo (IC
50 = 30 nM). Similarly, SB 225002 reduces neutrophil influx, the production of inflammatory mediators, and tissue damage in TNBS-
induced colitis in mice.
Verwenden
SB 225002 is a potent and selective CXCR2 antagonist with the ability to inhibit interleukin IL-8 binding to CXCR2.
Biologische Aktivität
Potent and selective CXCR2 chemokine receptor antagonist (IC 50 = 22 nM) that displays > 150-fold selectivity over CXCR1 receptors. Causes inhibition of IL-8 and GRO α -mediated calcium mobilization in HL60 cells (IC 50 values are 8 and 10 nM respectively). Prevents IL-8-induced neutrophil chemotaxis in vitro and sequestration in vivo . Inhibits HIV replication in lymphocytes and macrophages.
SB 225002 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
SB 225002 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 130)Lieferanten
- SB 225002
- N-(2-HYDROXY-4-NITROPHENYL)-N'-(2-BROMOPHENYL)UREA
- N-(2-BROMOPHENYL)-N'-(2-HYDROXY-4-NITROPHENYL)UREA
- 1-(2-bromophenyl)-3-(2-hydroxy-4-nitrophenyl)urea
- SB 225002 - CAS 182498-32-4 - Calbiochem
- SB-225002;SB 225002
- Urea, N-(2-bromophenyl)-N'-(2-hydroxy-4-nitrophenyl)-
- SB 225002 USP/EP/BP
- SB225002 182498-32-4
- 182498-32-4
- 18298-32-4
- Inhibitors
- A potent, selective, and competitive antagonist of the G-protein coupled receptor CXCR2.
- Antineoplastic
