10,11-Dihydro-N,N-dimethyl-5H-dibenz(b,f)azepin-5-propanamin
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- CAS-Nr.
- 50-49-7
- Bezeichnung:
- 10,11-Dihydro-N,N-dimethyl-5H-dibenz(b,f)azepin-5-propanamin
- Englisch Name:
- IMIPRAMINE
- Synonyma:
- IM;DPID;Irmin;Iramil;Imizin;Imiprin;Imizine;Surplix;Timolet;Censtim
- CBNumber:
- CB1727489
- Summenformel:
- C19H24N2
- Molgewicht:
- 280.41
- MOL-Datei:
- 50-49-7.mol
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10,11-Dihydro-N,N-dimethyl-5H-dibenz(b,f)azepin-5-propanamin Eigenschaften
- Schmelzpunkt:
- 174°C
- Siedepunkt:
- bp0.1 160°
- Dichte
- 0.9935 (rough estimate)
- Brechungsindex
- 1.5640 (estimate)
- pka
- pKa 9.66(H2O,t = 25,I=0.025) (Uncertain)
- Wasserlöslichkeit
- 18.23mg/L(24 ºC)
- Solvent
- Ethanol under nitrogen
- Concentration
- 1 mCi/ml
- Specific Activity
- 60-90 Ci/mmol
- BCS Class
- 1
- EPA chemische Informationen
- Imipramine (50-49-7)
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| Giftige Stoffe Daten |
50-49-7(Hazardous Substances Data) |
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| Toxizität |
A tertiary amine tricyclic antidepressant that is thought
to exert its therapeutic effect by inhibiting the reuptake of serotonin
and norepinephrine centrally. A major metabolite is N-desmethylimipramine
(desipramine), also used as an antidepressant
drug. Desipramine differs from imipramine in being a better
blocker of norepinephrine, rather than serotonin, uptake. Side
effects, including sedation and drowsiness, dry mouth, urinary
retention, constipation, and orthostatic hypotension, are probably
due to the anticholinergic, anti-α-adrenergic, and antihistaminergic
receptor-blocking properties. Imipramine should not be used
in conjunction with a monoamine oxidase inhibitor or other
treatment that increases catecholamine concentrations (e.g.,
drugs containing sympathomimetic amines). Imipramine should
be avoided in patients with cardiovascular disease or seizure disorder,
or in those who may abuse alcohol, as imipramine lowers
seizure threshold, can produce cardiovascular toxicity and may
potentiate the effects of alcohol. Imipramine intoxication can
include CNS abnormalities (e.g., drowsiness, stupor, coma, and
extrapyramidal symptoms), cardiac arrhythmia, and respiratory
depression. Children appear to be particularly vulnerable to the
cardiotoxic and seizure-inducing effects of high doses of imipramine.
The oral LD50 in female rats is 305 mg/kg. |
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| Bildanzeige (GHS) |
 
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| Alarmwort |
Achtung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitsschädlich bei Verschlucken. |
Akute Toxizität oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
| H336 |
Kann Schläfrigkeit und Benommenheit verursachen. |
Spezifische Zielorgan-Toxizität (einmalige Exposition) |
Kategorie 3 (Schläfrigkeit und Benommenheit) |
Warnung |
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P261, P271, P304+P340, P312,P403+P233, P405, P501 |
| H370 |
Schädigt die Organe. |
Spezifische Zielorgan-Toxizität (einmalige Exposition) |
Kategorie 1 |
Achtung |
![GHS hazard pictograms]() src="/GHS08.jpg" width="20" height="20" /> |
P260, P264, P270, P307+P311, P321,P405, P501 |
| H400 |
Sehr giftig für Wasserorganismen. |
Kurzfristig (akut) gewässergefährdend |
Kategorie 1 |
Warnung |
![GHS hazard pictograms]() src="/GHS09.jpg" width="20" height="20" /> |
P273, P391, P501 |
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| Sicherheit |
| P260 |
Dampf/Aerosol/Nebel nicht einatmen. |
| P261 |
Einatmen von Staub vermeiden. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P270 |
Bei Gebrauch nicht essen, trinken oder rauchen. |
| P271 |
Nur im Freien oder in gut belüfteten Räumen verwenden. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P304+P340 |
BEI EINATMEN: Die Person an die frische Luft bringen und für ungehinderte Atmung sorgen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen. |
| P307+P311 |
BEI Exposition: GIFTINFORMATIONSZENTRUM oder Arzt anrufen. |
| P312 |
Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen. |
| P321 |
Besondere Behandlung |
| P403+P233 |
An einem gut belüfteten Ort aufbewahren. Behälter dicht verschlossen halten. |
| P405 |
Unter Verschluss aufbewahren. |
| P501 |
Inhalt/Behälter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen. |
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10,11-Dihydro-N,N-dimethyl-5H-dibenz(b,f)azepin-5-propanamin Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
Imipramine is used in depression of various etiology accompanied by motor
clumsiness and enuresis in children and Parkinson’s disease.
Mechanism of action
Besides being used in the clinical treatment of depression, imipramine also has been used for the treatment
of functional enuresis in children who are at least 6 years of age (25 mg daily administered 1 hour before
bedtime, not to exceed 2.5 mg/kg daily).
Clinical Use
Imipramine is a 10,11-dihydrodibenzazepine tertiary amine TCA that is marketed as hydrochloride
and pamoate salts, both of which are administered orally. Although the hydrochloride salt may be
administered in divided daily doses, imipramine's long duration of action suggests that the entire oral daily
dose may be administered at one time.On the other hand, imipramine pamoate usually is administered as a
single daily oral dose.
10,11-Dihydro-N,N-dimethyl-5H-dibenz(b,f)azepin-5-propanamin Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
10,11-Dihydro-N,N-dimethyl-5H-dibenz(b,f)azepin-5-propanamin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 70)Lieferanten
50-49-7(10,11-Dihydro-N,N-dimethyl-5H-dibenz(b,f)azepin-5-propanamin)Verwandte Suche:
1'-(3-(10,11-Dihydro-5H-dibenz-(b,f)azepin-5-yl)-propyl)-(1,4'-bipiperidin)-4'-carboxamid
Trimipramin
10,11-Dihydro-N,N-dimethyl-5H-dibenz(b,f)azepin-5-propanamin
10,11-Dihydro-5H-dibenz[b,f]azepin
Desipramin
Clomipramin
Trimipraminhydrogenmaleat
Clomipraminhydrochlorid
Imipraminoxid
5H-Dibenz(b,f)azepin-5-propanamin, 10,11-dihydro-N,N-dimethyl-monohydrochlorid
Lofepramin
1'-[3-(10,11-Dihydro-5H-dibenz(b,f)azepin-5-yl)propyl][1,4'-bipiperidin]-4'-carboxamiddihydrochlorid
1'-[3-(3-Chlor-10,11-dihydro-5H-dibenz(b,f)azepin-5-yl)propyl][1,4'-bipiperidin]-4'-carboxamiddihydrochlorid
4,4'-Methylenbis[3-hydroxy-2-naphthoe]sure, Verbindung mit 10,11-Dihydro-N,N-dimethyl-5H-dibenz[b,f]azepin-5-propylamin (1:2)
- IM
- Imidobenzyle
- Imipramina
- Imiprin
- Imizin
- Imizine
- Imizinum
- Impramine
- Intalpram
- Iramil
- Irmin
- Melipramin
- Melipramine
- N-(3-Dimethylaminopropyl)-o-iminodibenzyl
- N-(gamma-Dimethylaminopropyl)iminodibenzyl
- Nelipramin
- Prazepine
- Promiben
- Psychoforin
- SK-Pramine
- Surplix
- Timolet
- Tofranil (free base)
- Tofranil, base
- Tofraniln A
- 3-(10,11-dihydrodibenz(b,f)azepin-5-yl)propyldimethylamine
- N-[γ-Dimethylaminopropyl] iminodibenzyl
- IMIPRAMINE,1.0MG/MLINMETHANOL
- IMIPRAMINE
- AURORA KA-7708
- 1-(3-Dimethylaminopropyl)-4,5-dihydro-2,3,6,7-dibenzazepine
- 10,11-Dihydro-5-(3-(dimethylamino)propyl)-5H-dibenz[b,f]azepine
- 2,2'-(3-Dimethylaminopropylimino)bibenzyl
- 2,2'-(3-Dimethylaminopropylimino)dibenzyl
- 3-(10,11-Dihydro-5H-dibenzo[b,f]azepin-5-yl)-N,N-dimethyl-1-propanamine
- 5-(3-(Dimethylamino)propyl)-10,11-dihydro-5H-dibenz(b,f)azepine
- 5-(3-Dimethylaminopropyl)-10,11-dihydro-5H-dibenzo(b,f)azepine
- 5H-Dibenz(b,f)azepine, 10,11-dihydro-5-(3-(dimethylamino)propyl)-
- 5H-Dibenz[b,f]azepine, 5-[3-(dimethylamino)propyl]-10,11-dihydro-
- 5H-Dibenz[b,f]azepine-5-propanamine, 10,11-dihydro-N,N-dimethyl-
- Antideprin
- Berkomine
- Censtim
- Censtin
- Declomipramine
- Dimipressin
- DPID
- Dynaprin
- Eupramin
- Imipramine (base and/or unspecified salts)
- N-[3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)propyl]-N,N-dimethylamine
- 10,11-Dihydro-N,N-dimethyl-5H-dibenz[b,f]azepine-5-(1-propanamine)
- 3-(4a,5-dihydro-4H-dibenzo[b,f]azepin-10-yl)-N,N-diMethylpropan-1-aMine
- 3-(10,11-Dihydro-5H-dibenzo[b,f]azepin-5-yl)-N,N-dimethylpropan-1-amine
- Clomipramine HCl EP Impurity B
- Trimipramine BP Impurity D
- Imipramine for system suitability CRS
- Imipramine (Clomipramine EP Impurity B)
