(3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride
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- CAS-Nr.
- 1062580-52-2
- Englisch Name:
- (3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride
- Synonyma:
- (3R,4R)-N,4-Dimethyl-1-(phenylmethyl)-3-piperidinamine hydrochloride;TOF30;Tofacitinib-1;Tofatinib Impurity 5;Tofacitinib interMediate A;Tofacitinib intermediate 3;piperidin-3-amine dihydrochL;Tofacitinib Impurity 123 DiHCl;Azilsartan medoxomil impurity351;Tofacitinib Impurity 5 Dihydrochloride
- CBNumber:
- CB21011155
- Summenformel:
- C14H23ClN2
- Molgewicht:
- 254.8
- MOL-Datei:
- Mol file
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(3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride Eigenschaften
- Schmelzpunkt:
- 249～251℃
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- Löslichkeit
- Aqueous Acid (Slightly), DMSO (Slightly, Heated, Sonicated), Methanol (Slightly)
- Aggregatzustand
- Solid
- Farbe
- White to Off-White
- InChI
- InChI=1/C14H22N2.ClH/c1-12-8-9-16(11-14(12)15-2)10-13-6-4-3-5-7-13;/h3-7,12,14-15H,8-11H2,1-2H3;1H/t12-,14+;/s3
- InChIKey
- FVRZQLQXDPJADE-WLZBWWFYNA-N
- SMILES
- C(C1C=CC=CC=1)N1CC[C@@H](C)[C@@H](NC)C1.Cl |&1:10,12,r|
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| HazardClass |
IRRITANT |
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| HS Code |
2933399990 |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitsschädlich bei Verschlucken. |
Akute Toxizität oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
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| Sicherheit |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P270 |
Bei Gebrauch nicht essen, trinken oder rauchen. |
| P301+P312 |
BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen. |
| P330 |
Mund ausspülen. |
| P501 |
Inhalt/Behälter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen. |
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(3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
(3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride can be used as organic synthesis intermediates and pharmaceutical intermediates, mainly used in laboratory research and development processes and chemical production processes.
Synthese
TiCl4(0.2g, 1mmol) and NEt3(0.15 g, 1.5 mmol) were added to toluene, and then add 1-benzyl-4-methyl-3-ketone piperidine (20.3 g, 100 mmol) at 35 ℃. The methylamine solution is added to the reaction solution (9.32 g, 120 mmol) and reaction for 4 h, followed by adding NaBH (OAC) 3 (0.32 g, 1.5 mmol) and glacial acetic acid 2 ml. After the reaction is complete, add saturated salt water to wash the reaction mixture. (3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride was obtained after further purification.
(3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
(3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 353)Lieferanten
| Firmenname |
Telefon |
E-Mail |
Land |
Produktkatalog |
Edge Rate |
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Changsha Junyu Chemexpress.co., Ltd
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+86-13723890100
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info@csjyyy.cn |
China |
134 |
58 |
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Shanghai Boc Chemical Co., Ltd.
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021-34975602; +8618721111801
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shangli@bocchem.com |
China |
138 |
58 |
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Purest Pharmaceuticl （Xi’an) Co,.LTD
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+8613893405577
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12829054@qq.com |
China |
74 |
58 |
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Hangzhou ICH Biofarm Co., Ltd
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+undefined8613073685410
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sales@ichemie.com |
China |
985 |
58 |
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hebei hongtan Biotechnology Co., Ltd
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+86-86-1913198-3935 +8617331935328
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sales03@chemcn.cn |
China |
951 |
58 |
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Capot Chemical Co.,Ltd.
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571-85586718 +8613336195806
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sales@capotchem.com |
China |
29797 |
60 |
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Beijing Cooperate Pharmaceutical Co.,Ltd
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010-60279497
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sales01@cooperate-pharm.com |
CHINA |
1811 |
55 |
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Henan Tianfu Chemical Co.,Ltd.
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+86-0371-55170693 +86-19937530512
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info@tianfuchem.com |
China |
21689 |
55 |
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Hangzhou FandaChem Co.,Ltd.
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008657128800458; +8615858145714
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fandachem@gmail.com |
China |
9342 |
55 |
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Nanjing ChemLin Chemical Industry Co., Ltd.
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025-83697070
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product@chemlin.com.cn |
CHINA |
3012 |
60 |
- CIS-N-BENZYL-3-METHYLAMINO-4-METHYL-PIPERIDINE BIS-(HYDROCHLORIDE)
- cis-1-Benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride
- cis-1-Benzyl-4-methyl-3-(methylamino)piperidine dihydrochloride 95+%
- cis-1-Benzyl-N3,4-dimethylpiperidin-3-amine dihydrochloride
- (3R,4R)-1-BENZYL-N,4-DIMETHYLPIPERIDIN-3-AMINE DIHYDROCHLORIDE
- (3R,4R)-1-benzyl-N,4-diMethylpiperidin-3-aMine BIS-(HYDROCHLORIDE)
- 3-PiperidinaMine, N,4-diMethyl-1-(phenylMethyl)-, hydrochloride (1:2), (3R,4R)-
- (3R,4R)-N,4-DiMethyl-1-(phenylMethyl)-3-piperidi
- (3R,4R)- Cis-1-benzyl-4-Methyl-3-(MethylaMino)piperidine
- Tofacitinib interMediate A
- (3R,4R)- cis-1-Benzyl-4-Methyl-3-(MethylaMino)piperidine dihydrochloride
- (3R,4R)-1-BENZYL-N,4-DIMETHYLPIPERIDIN-3-AMINE DIHYDROCHLORID
- 3-Piperidinamine, N,4-dimethyl-1-(phenylmethyl)-, dihydrochloride, (3R,4R)-
- Tofacitinib intermediate 3
- (3R,4R)-(1-Benzyl-4-methyl-piperidin-3-yl)-methyl-amine dihydrochloride
- Azilsartan medoxomil impurity351
- (3R,4R)-N,4-Dimethyl-1-(phenylmethyl)-3-piperidinamine hydro...
- Tofacitinib Impurity 5 Dihydrochloride
- N-((3R,4R)-N,4-Dimethyl-1-(phenylmethyl)-3-piperidinamine hydrochloride
- (3R,4R)-1-BENZYL-N,4-DIMETHYLPIPERIDIN-3-AMINE 2HCL
- (3R,4R)-1-BENZYL-N,4-DIMETHYLPIPERIDIN-3-AMINEDITYDROCHLORIDE
- Cis-n-benzyl-3-methylamino-4-methyl-piperidine bis-(, HCl )
- (3R,?4R)?-N,?4-?Dimethyl-?1-?(phenylmethyl)?-3-?piperidinamine Dihydrochloride
- piperidin-3-amine dihydrochL
- (3R,4R)-N,4-Dimethyl-1-(phenylmethyl)-3-piperidinamine, hydrochloride (1:2)
- Cis 1-benzyl-4-methyl-3-methylamino-piperidine hydrochloride
- Tofacitinib-1
- TOF30
- (3R,4R)-1-Benzyl-3-(methylamino)-4-methylpiperidine Dihydrochloride
- (3R,4R)-N,4-Dimethyl-1-(phenylmethyl)-3-piperidinamine HCl
- (3R,4R)-N,4-Dimethyl-1-(phenylmethyl)-3-piperidinamine hydrochloride
- (3R,4R)-N, 4-dimethyl-1 -(phenylmethyl) -3-piperidamine hydrochloride
- Tofatinib Impurity 5
- (3R,4R)-N,4-Dimethy1-(phenylmethyl)-3-piperidinamine hydrochloride
- CIS-N-BENZYL-3-METHYLAMINO-4-METHYL-PIPERIDINE BIS-(HYDROCHLORIDE) Tofacitinib （Int.）
- Tofacitinib Impurity 123 DiHCl
- (3R,4R)-N,4-Dimethyl-1-(benzyl)-3-piperidinamine 2HCl
- (3R,4R)-1-Benzyl-N,4-dimethyl-3-piperidinamine dihydrochloride
- 1062580-52-2
- C14H22N22HCl
- 1
