(3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride
- CAS No.
- 1062580-52-2
- Chemical Name:
- (3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride
- Synonyms
- (3R,4R)-N,4-Dimethyl-1-(phenylmethyl)-3-piperidinamine hydrochloride;TOF30;Tofacitinib-1;Tofatinib Impurity 5;Tofacitinib interMediate A;Tofacitinib intermediate 3;piperidin-3-amine dihydrochL;Tofacitinib Impurity 123 DiHCl;Azilsartan medoxomil impurity351;Tofacitinib Impurity 5 Dihydrochloride
- CBNumber:
- CB21011155
- Molecular Formula:
- C14H23ClN2
- Molecular Weight:
- 254.8
- MDL Number:
- MFCD09864744
- MOL File:
- Mol file
Melting point | 249~251℃ |
---|---|
storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
solubility | Aqueous Acid (Slightly), DMSO (Slightly, Heated, Sonicated), Methanol (Slightly) |
form | Solid |
color | White to Off-White |
InChI | InChI=1/C14H22N2.ClH/c1-12-8-9-16(11-14(12)15-2)10-13-6-4-3-5-7-13;/h3-7,12,14-15H,8-11H2,1-2H3;1H/t12-,14+;/s3 |
InChIKey | FVRZQLQXDPJADE-WLZBWWFYNA-N |
SMILES | C(C1C=CC=CC=1)N1CC[C@@H](C)[C@@H](NC)C1.Cl |&1:10,12,r| |
FDA UNII | H9652393WE |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H302 |
Precautionary statements | P264-P270-P301+P312-P330-P501 |
HazardClass | IRRITANT |
HS Code | 2933399990 |
(3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride price More Price(20)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
TRC | D480190 | (3R,4R)-N,4-Dimethyl-1-(phenylmethyl)-3-piperidinamineDihydrochloride | 1062580-52-2 | 10g | $235 | 2021-12-16 | Buy |
Apolloscientific | OR54340 | cis-1-Benzyl-4-methyl-3-(methylamino)piperidine dihydrochloride 95+% | 1062580-52-2 | 25g | $311 | 2021-12-16 | Buy |
SynQuest Laboratories | 3H31-5-2Q | (3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-aminedihydrochloride 97.0% | 1062580-52-2 | 1g | $490 | 2021-12-16 | Buy |
Medical Isotopes, Inc. | 35378 | (3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-aminedHCl 95+% | 1062580-52-2 | 1000mg | $550 | 2021-12-16 | Buy |
AK Scientific | 1409AA | (3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-aminedihydrochloride | 1062580-52-2 | 1g | $72 | 2021-12-16 | Buy |
(3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride Chemical Properties,Uses,Production
Uses
(3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride can be used as organic synthesis intermediates and pharmaceutical intermediates, mainly used in laboratory research and development processes and chemical production processes.
Uses
(3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride is a related compound of Tofacitinib (T528000). (3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride can be used to prepare janus kinase 1 selective inhibitor.
Synthesis
TiCl4(0.2g, 1mmol) and NEt3(0.15 g, 1.5 mmol) were added to toluene, and then add 1-benzyl-4-methyl-3-ketone piperidine (20.3 g, 100 mmol) at 35 ℃. The methylamine solution is added to the reaction solution (9.32 g, 120 mmol) and reaction for 4 h, followed by adding NaBH (OAC) 3 (0.32 g, 1.5 mmol) and glacial acetic acid 2 ml. After the reaction is complete, add saturated salt water to wash the reaction mixture. (3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride was obtained after further purification.
(3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride Preparation Products And Raw materials
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Changsha Junyu Chemexpress.co., Ltd | +86-13723890100 | info@csjyyy.cn | China | 134 | 58 |
Shanghai Boc Chemical Co., Ltd. | 021-34975602; +8618721111801 | shangli@bocchem.com | China | 138 | 58 |
Purest Pharmaceuticl (Xi’an) Co,.LTD | +8613893405577 | 12829054@qq.com | China | 74 | 58 |
Hangzhou ICH Biofarm Co., Ltd | +86-0571-28186870; +undefined8613073685410 | sales@ichemie.com | China | 990 | 58 |
hebei hongtan Biotechnology Co., Ltd | +86-86-1913198-3935 +8617331935328 | sales03@chemcn.cn | China | 973 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29798 | 60 |
Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1811 | 55 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21667 | 55 |
Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9308 | 55 |
Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3012 | 60 |
View Lastest Price from (3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-09-23 | (3R,4R)-N,4-Dimethyl-1-(phenylmethyl)-3-piperidinamine hydrochloride
1062580-52-2
|
US $0.00 / kg | 1kg | 99% | 20mt | Jinan Finer Chemical Co., Ltd | ||
2024-09-23 | (3R,4R)-N,4-Dimethyl-1-(phenylmethyl)-3-piperidinamine hydrochloride
1062580-52-2
|
US $30.00 / kg | 1kg | 98% | 2000kg | hebei hongtan Biotechnology Co., Ltd | ||
2024-09-14 | (3R,4R)-N,4-Dimethyl-1-(phenylmethyl)-3-piperidinamine hydrochloride
1062580-52-2
|
US $0.00 / kg | 1kg | 99% | 500kg | Shanghai Joiny Pharmaceutical Co.,LTD |
- (3R,4R)-N,4-Dimethyl-1-(phenylmethyl)-3-piperidinamine hydrochloride
1062580-52-2
- US $0.00 / kg
- 99%
- Jinan Finer Chemical Co., Ltd
- (3R,4R)-N,4-Dimethyl-1-(phenylmethyl)-3-piperidinamine hydrochloride
1062580-52-2
- US $30.00 / kg
- 98%
- hebei hongtan Biotechnology Co., Ltd
- (3R,4R)-N,4-Dimethyl-1-(phenylmethyl)-3-piperidinamine hydrochloride
1062580-52-2
- US $0.00 / kg
- 99%
- Shanghai Joiny Pharmaceutical Co.,LTD
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