DL-TBOA

DL-TBOA Struktur
205309-81-5
CAS-Nr.
205309-81-5
Englisch Name:
DL-TBOA
Synonyma:
DL-TBOA;DLTBOA,DL TBOA;BYOBCYXURWDEDS-IUCAKERBSA-N;D,L-THREO-B-BENZYLOXYASPARTATE;DL-threo-β-Benzyloxyasparticacid;DL-THREO-BETA-BENZYLOXYASPARTIC ACID;D-Aspartic acid, 3-(phenylmethoxy)-, (3R)-rel-
CBNumber:
CB2208679
Summenformel:
C11H13NO5
Molgewicht:
239.22
MOL-Datei:
Mol file

DL-TBOA Eigenschaften

Siedepunkt:
421.7±45.0 °C(Predicted)
Dichte
1.392±0.06 g/cm3(Predicted)
storage temp. 
Desiccate at -20°C
Löslichkeit
<23.92mg/ml in DMSO;insoluble in H2O
Aggregatzustand
solid
pka
2.07±0.27(Predicted)
Farbe
White

Sicherheit

DL-TBOA Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

DL-TBOA is an inhibitor of excitatory amino acid transporters (EAATs), with IC50 values of 67 and 5.5 μM for glutamate uptake in COS-1 cells expressing human EAAT1 and EAAT2, respectively. It inhibits inward currents induced by L-aspartate in EAAT4-expressing Xenopus oocytes (Ki = 4.4 μM) and by L-glutamate in EAAT5-expressing oocytes (Ki = 3.2 μM) voltage-clamped at -60 mV. In vivo, DL-TBOA (500 μM, intrahippocampal perfusion) increases extracellular aspartate, glutamate, and alanine levels in rat hippocampus. Intrahippocampal injection of DL-TBOA increases lesion volume in the rat CA1 region in a dose-dependent manner and induces hyperexcitability, wet-dog shakes, salivation, forelimb myoclonus, limbic seizures, and epileptic EEG discharges at a dose of 25 nmol. DL-TBOA (5 and 10 μg, intrathecal) induces antinociception in the second phase of the formalin test in rats when administered 10 minutes prior to formalin.

Verwenden

DL-TBOA is a non-transportable excitatory amino acid transporter (EAAT) inhibitor (1). DL-TBOA is a glutamate uptake inhibitor.

DL-TBOA Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


DL-TBOA Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 38)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000
marketing@targetmol.com United States 19892 58
Aladdin Scientific
+1-833-552-7181
sales@aladdinsci.com United States 52927 58
3B Pharmachem (Wuhan) International Co.,Ltd. 821-50328103-801 18930552037
3bsc@sina.com China 15848 69
EMMX Biotechnology LLC 888-539-0666
info@emmx.com United States 8449 60
Fan De(Beijing) Biotechnology Co., Ltd. 15911056312
liming@bio-fount.com China 9730 58
BOC Sciences --
info@bocsci.com USA 0 65
Jiangsu Hongmin Pharmaceutical Co., Ltd. 18221292452
fannieliu@glschina.com China 6799 58
MedBioPharmaceutical Technology Inc 021-69568360 18916172912
order@med-bio.cn China 8141 58
Energy Chemical 021-58432009 400-005-6266
marketing@energy-chemical.com China 44941 58
Beijing Jin Ming Biotechnology Co., Ltd. 010-60605840 15801484223
psaitong@jm-bio.com China 29834 58

  • DL-THREO-BETA-BENZYLOXYASPARTIC ACID
  • D,L-THREO-B-BENZYLOXYASPARTATE
  • DL-TBOA
  • DL-threo-β-Benzyloxyasparticacid
  • D-Aspartic acid, 3-(phenylmethoxy)-, (3R)-rel-
  • BYOBCYXURWDEDS-IUCAKERBSA-N
  • DLTBOA,DL TBOA
  • 205309-81-5
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