DL-TBOA
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DL-TBOA 속성
- 끓는 점
- 421.7±45.0 °C(Predicted)
- 밀도
- 1.392±0.06 g/cm3(Predicted)
- 저장 조건
- Desiccate at -20°C
- 용해도
- <23.92mg/ml in DMSO;insoluble in H2O
- 물리적 상태
- 고체
- 물리적 상태
- 단단한 모양
- 산도 계수 (pKa)
- 2.07±0.27(Predicted)
- 색상
- 하얀색
안전
DL-TBOA C화학적 특성, 용도, 생산
개요
DL-TBOA is an inhibitor of excitatory amino acid transporters (EAATs), with IC50 values of 67 and 5.5 μM for glutamate uptake in COS-1 cells expressing human EAAT1 and EAAT2, respectively. It inhibits inward currents induced by L-aspartate in EAAT4-expressing Xenopus oocytes (Ki = 4.4 μM) and by L-glutamate in EAAT5-expressing oocytes (Ki = 3.2 μM) voltage-clamped at -60 mV. In vivo, DL-TBOA (500 μM, intrahippocampal perfusion) increases extracellular aspartate, glutamate, and alanine levels in rat hippocampus. Intrahippocampal injection of DL-TBOA increases lesion volume in the rat CA1 region in a dose-dependent manner and induces hyperexcitability, wet-dog shakes, salivation, forelimb myoclonus, limbic seizures, and epileptic EEG discharges at a dose of 25 nmol. DL-TBOA (5 and 10 μg, intrathecal) induces antinociception in the second phase of the formalin test in rats when administered 10 minutes prior to formalin.용도
DL-TBOA is a non-transportable excitatory amino acid transporter (EAAT) inhibitor (1). DL-TBOA is a glutamate uptake inhibitor.DL-TBOA 준비 용품 및 원자재
원자재
준비 용품
DL-TBOA 공급 업체
글로벌( 38)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 19892 | 58 |
| Aladdin Scientific | +1-833-552-7181 |
sales@aladdinsci.com | United States | 52927 | 58 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 |
3bsc@sina.com | China | 15848 | 69 |
| EMMX Biotechnology LLC | 888-539-0666 |
info@emmx.com | United States | 8449 | 60 |
| Fan De(Beijing) Biotechnology Co., Ltd. | 15911056312 |
liming@bio-fount.com | China | 9730 | 58 |
| BOC Sciences | -- |
info@bocsci.com | USA | 0 | 65 |
| Jiangsu Hongmin Pharmaceutical Co., Ltd. | 18221292452 |
fannieliu@glschina.com | China | 6799 | 58 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 |
order@med-bio.cn | China | 8141 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 |
marketing@energy-chemical.com | China | 44941 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 15801484223 |
psaitong@jm-bio.com | China | 29834 | 58 |