(15R)-18,21-Didehydro-17-demethoxy-18,21-dideoxo-18,21-dihydroxy-15-methoxygeldanamycin

(15R)-18,21-Didehydro-17-demethoxy-18,21-dideoxo-18,21-dihydroxy-15-methoxygeldanamycin Struktur
91700-91-3
CAS-Nr.
91700-91-3
Englisch Name:
(15R)-18,21-Didehydro-17-demethoxy-18,21-dideoxo-18,21-dihydroxy-15-methoxygeldanamycin
Synonyma:
TAN-420C;DihydroherbiMycin C;Antibiotic TAN-420C;(15R)-18,21-Didehydro-17-demethoxy-18,21-dideoxo-18,21-dihydroxy-15-methoxygeldanamycin;Geldanamycin, 18,21-didehydro-17-demethoxy-18,21-dideoxo-18,21-dihydroxy-15-methoxy-, (15R)-
CBNumber:
CB22234544
Summenformel:
C29H42N2O9
Molgewicht:
562.656
MOL-Datei:
91700-91-3.mol

(15R)-18,21-Didehydro-17-demethoxy-18,21-dideoxo-18,21-dihydroxy-15-methoxygeldanamycin Eigenschaften

Siedepunkt:
733.7±60.0 °C(Predicted)
Dichte
1.25±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
Löslichkeit
DMF: soluble,DMSO: soluble,Ethanol: soluble,Methanol: soluble
pka
9.90±0.70(Predicted)

Sicherheit

(15R)-18,21-Didehydro-17-demethoxy-18,21-dideoxo-18,21-dihydroxy-15-methoxygeldanamycin Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

TAN 420C is a hydroquinone ansamycin antibiotic originally isolated from Streptomyces. It exhibits antibacterial activity against B. brevis and M. flavus (MICs = 50 and 25 μg/mL, respectively). Additionally, it inhibits proliferation in the lymphocytic leukemia cell lines P388 and KB (ED50s = 0.34 and 3.49 μg/mL, respectively).

Verwenden

TAN 420C is a minor analogue of the herbimycin complex, isolated from Streptomyces hygroscopicus. TAN 420C is the hydroquinone of herbimycin C, and is known to exhibit antitumour activity. TAN 420C converts Rous sarcoma virus-infected rat kidney cells into normal cells.

(15R)-18,21-Didehydro-17-demethoxy-18,21-dideoxo-18,21-dihydroxy-15-methoxygeldanamycin Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


(15R)-18,21-Didehydro-17-demethoxy-18,21-dideoxo-18,21-dihydroxy-15-methoxygeldanamycin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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  • (15R)-18,21-Didehydro-17-demethoxy-18,21-dideoxo-18,21-dihydroxy-15-methoxygeldanamycin
  • Antibiotic TAN-420C
  • TAN-420C
  • DihydroherbiMycin C
  • Geldanamycin, 18,21-didehydro-17-demethoxy-18,21-dideoxo-18,21-dihydroxy-15-methoxy-, (15R)-
  • 91700-91-3
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