3-AMINO-1H-PYRAZOLO[3,4-B]QUINOXALINE

40254-90-8

CAS-Nr.: 40254-90-8

Englisch Name:: 3-AMINO-1H-PYRAZOLO[3,4-B]QUINOXALINE

Synonyma:: NSC 693868;Brimonidine Impurity 8;Cdk1/5 Inhibitor inhibitor;3-Aminopyrazolo[3,4-b]quinoxaline;1H-PYRAZOLO[3,4-B]QUINOXALIN-3-AMINE;3-AMINO-1H-PYRAZOLO[3,4-B]QUINOXALINE;1H-Pyrazolo[3,4-b]quinoxalin-3-ylamine;1H-Pyrazolo[3,4-b]quinoxalin-3-amine(9CI);Cdk1/5 Inhibitor - CAS 40254-90-8 - Calbiochem

CBNumber:: CB2381002

Summenformel:: C9H7N5

Molgewicht:: 185.19

MOL-Datei:: 40254-90-8.mol

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Eigenschaften Sicherheit Verwendungswort Produktionsfirma 51

3-AMINO-1H-PYRAZOLO[3,4-B]QUINOXALINE Eigenschaften

Schmelzpunkt:: 292-293℃ (ethanol )

Siedepunkt:: 522.8±45.0 °C(Predicted)

Dichte: 1.570±0.06 g/cm3(Predicted)

storage temp.: Store at +4°C

Löslichkeit: Soluble to 100 mM in DMSO

Aggregatzustand: Red solid

pka: 7.40±0.50(Predicted)

Sicherheit

Kennzeichnung gefährlicher	T
R-Sätze:	25
S-Sätze:	45
RIDADR	UN 2811 6.1 / PGIII

3-AMINO-1H-PYRAZOLO[3,4-B]QUINOXALINE Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Cyclin-dependent kinases (Cdks) are key regulators of cell cycle progression and are therefore promising targets for cancer therapy. Cdk1/5 Inhibitor is a pyrazolo [3,4-b] quioxaline that inhibits Cdk1/cyclin B and Cdk5/p25 (IC₅₀s = 600 and 400 nM, respectively). It less potently inhibits GSK3β (IC₅₀ = 1 μM) and does not block Cdc25 activity. This compound is used to help define the roles of Cdk1 and Cdk5 in various signaling pathways.

Verwenden

Cyclin-dependent kinases (CDKs) are protein kinases and involved with the regulation of the cell cycle. NSC 693868 is an inhibitor of Cdk1/cyclin B and Cdk5/p25.?Small molecules that target these protein kinases are valuable tools for investigating cellular signaling pathways and are potential therapeutic agents.

Biologische Aktivität

Inhibitor of cyclin-dependent kinases (cdks) and glycogen synthase kinase-3 (GSK-3). IC 50 values are 0.6, 0.4 and 1 μ M for cdk1/cyclin B, cdk5/p25 and GSK-3 respectively.

3-AMINO-1H-PYRAZOLO[3,4-B]QUINOXALINE Upstream-Materialien And Downstream Produkte

Upstream-Materialien

3-Chloroquinoxaline-2-carbonitrile

Downstream Produkte

3-AMINO-1H-PYRAZOLO[3,4-B]QUINOXALINE Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 51)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	+86-057181025280; +8617767106207	sales@molcore.com	China	49739	58
ZHEJIANG JIUZHOU CHEM CO., LTD	+86-0576225566889 +86-13454675544	admin@jiuzhou-chem.com；jamie@jiuzhou-chem.com；alice@jiuzhou-chem.com	China	19949	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	52927	58
3B Pharmachem (Wuhan) International Co.,Ltd.	821-50328103-801 18930552037	3bsc@sina.com	China	15848	69
EMMX Biotechnology LLC	888-539-0666	info@emmx.com	United States	8449	60
BOC Sciences	--	info@bocsci.com	USA	0	65
Jinan blalong chemical co. LTD	2710913286@.com	1513643261@qq.com	China	14253	58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	18818260767	sales@chemegen.com	China	11289	58
MedBioPharmaceutical Technology Inc	021-69568360 18916172912	order@med-bio.cn	China	8141	58

1H-PYRAZOLO[3,4-B]QUINOXALIN-3-AMINE
3-AMINO-1H-PYRAZOLO[3,4-B]QUINOXALINE
NSC 693868
1H-Pyrazolo[3,4-b]quinoxalin-3-amine(9CI)
3-Aminopyrazolo[3,4-b]quinoxaline
1H-Pyrazolo[3,4-b]quinoxalin-3-ylamine
Cdk1/5 Inhibitor - CAS 40254-90-8 - Calbiochem
Brimonidine Impurity 8
Cdk1/5 Inhibitor inhibitor
40254-90-8
C9H7N5
Protein Kinase
PIPERIDINE