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2'-Desoxyuridin

2'-Deoxyuridine Struktur
951-78-0
CAS-Nr.
951-78-0
Bezeichnung:
2'-Desoxyuridin
Englisch Name:
2'-Deoxyuridine
Synonyma:
2;DU;deoxyuridine;1-((2R,4S,5R)-4-Hydroxy-5-(hydroxyMethyl)tetrahydrofuran-2-yl)pyriMidine-2,4(1H,3H)-dione;durd;2'-dU;NSC 23615;Uracildeoxyr;Deoxy-uridin;DEOXYURIDINE-2'
CBNumber:
CB3472057
Summenformel:
C9H12N2O5
Molgewicht:
228.2
MOL-Datei:
951-78-0.mol
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2'-Desoxyuridin Eigenschaften

Schmelzpunkt:
167-169 °C(lit.)
Siedepunkt:
370.01°C (rough estimate)
alpha 
D22 +50° (c = 1.1 in N NaOH)
Dichte
1.3705 (rough estimate)
Brechungsindex
52 ° (C=1, 1mol/L NaOH)
storage temp. 
Inert atmosphere,2-8°C
Löslichkeit
DMSO (Slightly), Methanol (Slightly, Heated), Water (Slightly)
pka
pKa 9.3(H2O t = 25) (Uncertain)
Aggregatzustand
Powder
Farbe
White to off-white
Wasserlöslichkeit
300 g/L (20 ºC)
Sensitive 
Air Sensitive
Merck 
14,2910
BRN 
24433
InChIKey
MXHRCPNRJAMMIM-ATRFCDNQSA-N
CAS Datenbank
951-78-0(CAS DataBase Reference)
EPA chemische Informationen
Uridine, 2'-deoxy- (951-78-0)
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Kennzeichnung gefährlicher Xn
R-Sätze: 36/37/38
S-Sätze: 22-24/25-37/39-36/37/39-26
WGK Germany  3
RTECS-Nr. YU7490000
F  10-23
Hazard Note  Air Sensitive
TSCA  Yes
HS Code  29349990
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitsschädlich bei Verschlucken. Akute Toxizität oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizität (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" />
Sicherheit
P261 Einatmen von Staub vermeiden.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

2'-Desoxyuridin Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:

R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.

S-Sätze Betriebsanweisung:

S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.

Beschreibung

2'-Deoxyuridine is an intermediate in the synthesis of thymidylate, which is a precursor for DNA synthesis. It has been shown to inhibit the enzymatic activity of enzymes responsible for synthesizing uridine and thymidylate, leading to neuronal death. 2'-Deoxyuridine has been used as a fluorescence probe for nucleic acids and as a polymerase chain reaction (PCR) substrate. It is also known to bind with toll-like receptor 4 (TLR4), which is involved in inflammatory responses.

Chemische Eigenschaften

White crystalline powder

Verwenden

2'-Deoxyuridine is frequently halogenated to create thymidine analogues useful for studies of DNA synthesis and degradation mechanisms. Derivatized 2'-Deoxyuridines used as labeling substrates include chloro-2'-deoxyuridine (CldU), bromodeoxyuridine (BrdU) and/or iododeoxyuridine (IdU). Other useful analogues of 2'-deoxyuridine include 5-ethynyl-2'-deoxyuridine (DdU) and 5-hydroxymethyl-2'-deoxyuridine (HmdU). Laboratory suppression of deoxyuridine is used to diagnose megaloblastic anemias due to vitamin B12 and folate deficiencies. Deoxyuridine (dU) is used to indirectly determine if there are sufficient levels of folate and cobalamin in cell or tissue samples.

Definition

ChEBI: 2'-deoxyuridine is a pyrimidine 2'-deoxyribonucleoside having uracil as the nucleobase. It has a role as a human metabolite, a Saccharomyces cerevisiae metabolite, an Escherichia coli metabolite and a mouse metabolite. It is functionally related to a uracil.

2'-Desoxyuridin Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

5-CHLORO-2'-DEOXYURIDINE 1-(BETA-D-2-DEOXYRIBOFURANOSYL)-4-(1,2,4-TRIAZOL-1-YL)-5-METHYLPYRIMIDIN-2-ONE 5-(2-HYDROXYETHYL)-2'-DEOXYURIDINE

2'-Desoxyuridin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 528)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Wuhu Nuowei chemistry Co., Ltd. 		+86-0553-2911116-802 +undefined17756524438
 sales1@nuowei-chem.com China 1642 58
SHANGHAI NOVRIBO BIOTECH
17821030819
 June.Liu@Desano.com China 73 58
Hebei Yanxi Chemical Co., Ltd. 		+8617531190177
 peter@yan-xi.com China 5993 58
airuikechemical co., ltd. 		+undefined86-15315557071
 sales02@airuikechemical.com China 994 58
Capot Chemical Co.,Ltd. 		571-85586718 +8613336195806
 sales@capotchem.com China 29797 60
Shanghai Daken Advanced Materials Co.,Ltd 		+86-371-66670886
info@dakenam.com China 15928 58
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512
 info@tianfuchem.com China 21691 55
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795
ivan@atkchemical.com China 32480 60
career henan chemical co 		+86-0371-86658258
sales@coreychem.com China 29914 58
Chengdu GLP biotechnology Co Ltd 		028-87075086 13350802083
 scglp@glp-china.com CHINA 1824 58

951-78-0(2'-Desoxyuridin)Verwandte Suche:

6-Methyluracil Uridine Cytidin 1-β-D-Arabinofuranosyl-(1H,3H)-pyrimidin-2,4-dion Uracil 3-α,12-α-Dihydroxy-5-β-cholan-24-sure 2'-Desoxyguanosin-5'-(dinatriumphosphat) 5'-Thymidylsure, Dinatriumsalz 5'-Uridylsure, 2'-Deoxy-, Dinatriumsalz DNA polymeraseⅠfrom E.coli 5-Brom-2'-deoxyuridin [3β(2R,3R),4α,6α,7α,15α(R),16β]-4,9-Epoxycevan-3,4,6,7,14,15,16,20-octol-6,7-diacetat-3-(2,3-dihydroxy-2-methylbutyrat)-15-(2-methylbutyrat) Doxifluridin DNA, SINGLE STRANDED, IMM. ON CELLULOSE, FROM CALF THYMUS* BrdU (Bromodeoxyuridine) 5-Fluor-2'-desoxyuridin 5-Methyluridin Trifluridin
  • 1-(2'-DEOXY-BETA-D-RIBOFURANOSYL)URACIL
  • 1-(2-DEOXY-BETA-D-RIBOFURANOSYL)URACIL
  • (+)-2'-DEOXYURIDINE
  • 2'-DEOXYURIDINE
  • DEOXYURIDINE-2'
  • (+)-2'-DEOXYURIDINE, 99+%
  • Uracildeoxyr
  • 1-(2-Deoxy-b-D-erythro-pentofuranosyl)uracil
  • NSC 23615
  • 1-(2-deoxy-á-d-ribofuranosyl)uracil
  • 2'-Deoxy-D-uridine
  • 1-[4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione
  • 2'-deoxy-uridin
  • 1-[4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidine-2,4(1H,3H)-dione
  • 1-(2-Deoxy--D-erythro-pentofuranosyl)uracil
  • 1-((2R,4R,5R)-4-HYDROXY-5-(HYDROXYMETHYL)TETRAHYDROFURAN-2-YL)PYRIMIDINE-2,4(1H,3H)-DIONE
  • 2-DEOXYURIDINE extrapure
  • 1-(2-Deoxy-β-D-ribofuranosyl)uracil, Uracil deoxyriboside
  • 1-(2-Deoxy-β-D-ribofuranosyl)uracil, 2μ-Deoxyuridine, Uracil deoxyriboside
  • Uridine, 2'-deoxy
  • 2'-dU
  • 1-[(2S,4R,5S)-4-hydroxy-5-(hydroxyMethyl)oxolan-2-yl]-1,2,3,4-tetrahydropyriMidine-2,4-dione
  • 2'-Deowyuridine
  • 2'-DEOXYURIDINE 99-100%
  • 1-(2-Deoxy-β-D-ribofuranosyl)uracil
  • Deoxy-uridin
  • 1-(2-Deoxy-beta-D-ribofuranosyl)uracil, Uracil deoxyriboside
  • URACIL DEOXYRIBOSIDE
  • 2’-desoxyuridine
  • deoxyriboseuracil
  • durd
  • uracildesoxyuridine
  • 5-Ethynyl-2&rsquo
  • 5-Hydroxymethyl-2&rsquo
  • 2'-Deoxyuridine(2'-dU)
  • 5-(2-Furanyl)-2&rsquo
  • 5-[N(6-(Trifluoroacetamido)hexyl)-3-(E)-acrylamido]-2&rsquo
  • 2'-Deoxyuridine >
  • 2-Deoxyuridine, 1-(beta-D-ribofuranosyl)-4-pyrimidinone
  • 2'-Deoxyuridine USP/EP/BP
  • -deoxyuridine N-Hydroxysuccinimide Ester
  • Cytarabine Impurity 19（2'-Deoxyuridine）
  • (E)-5-(2-Carboxyvinyl)-2&rsquo
  • (E)-5-(2-Carbomethoxyvinyl)-2&rsquo
  • S4-(2-Cyanoethyl)-4-thio-2&rsquo
  • -deoxyuridine-d1
  • DU
  • 1-((2R,4S,5R)-4-Hydroxy-5-(hydroxyMethyl)tetrahydrofuran-2-yl)pyriMidine-2,4(1H,3H)-dione
  • 2
  • deoxyuridine
  • (+)-2`-Deoxyuridine
  • 2‘-dU/ 2'-Deoxyuridine
  • 1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4(1H,3H)-dione (2’-deoxyuridine)
  • 2'-Deoxyuridine, ≥ 98.0%
  • 2'-Deoxyuridine(2'-dU)
  • 2'-Deoxyuridine
  • 2''-Deoxyuridine
  • 951-78-0
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