NS 3694

NS 3694 Struktur
426834-38-0
CAS-Nr.
426834-38-0
Englisch Name:
NS 3694
Synonyma:
Apoptosis Inhibitor II, NS3694;Apoptosis Inhibitor II, NS3694 - CAS 426834-38-0 - Calbiochem;Benzoic acid, 4-chloro-2-[[[[3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-;NS 3694,Inhibitor,Apaf-1,Apoptosis,inhibit,caspase-9,NS-3694,apoptosome inhibitor,NS3694,cytochrome c
CBNumber:
CB4498300
Summenformel:
C15H10ClF3N2O3
Molgewicht:
358.7
MOL-Datei:
426834-38-0.mol

NS 3694 Eigenschaften

storage temp. 
2-8°C
Löslichkeit
DMSO: 22 mg/mL, soluble
Aggregatzustand
solid

Sicherheit

WGK Germany  3

NS 3694 Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Cytochrome c, which leaks from the mitochondrial intermembrane space into the cytosol, causes oligomerization of apoptotic protease-activating factor 1 (Apaf-1), forming a caspase activation complex known as the apoptosome. NS3694 is a cell-permeable diarylurea compound that inhibits apoptosome formation and caspase activation. It blocks cytochrome c-induced caspase activation in HeLa cell cytosolic extracts with an IC50 value of approximately 50 μM. NS3694 prevents the formation of apoptosomes, which prevents the association of procaspases with Apaf-1. It suppresses caspase activation and apoptosis in cells treated with either TNF-α or staurosporine . NS3694 is used to examine the role of apoptosome-mediated caspase activation in cell death.

Verwenden

NS3694 is a suppressor of the formation of apoptosome Apaf-1.

NS 3694 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


NS 3694 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 28)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Career Henan Chemica Co
+86-0371-86658258 15093356674;
laboratory@coreychem.com China 30255 58
Hangzhou MolCore BioPharmatech Co.,Ltd.
+86-057181025280; +8617767106207
sales@molcore.com China 49739 58
Aladdin Scientific
+1-+1(833)-552-7181
sales@aladdinsci.com United States 52927 58
VDM Biochemicals 0330-2528181
sales@vdmbio.com United States 510 64
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627
info@efebio.com China 9708 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767
sales@chemegen.com China 11289 58
MedBioPharmaceutical Technology Inc 021-69568360 18916172912
order@med-bio.cn China 8141 58
Energy Chemical 021-58432009 400-005-6266
marketing@energy-chemical.com China 44941 58
InvivoChem 13549236410
sales@invivochem.cn China 6749 58
TargetMol Chemicals Inc. 4008200310
marketing@tsbiochem.com China 24017 58

426834-38-0()Verwandte Suche:


  • Apoptosis Inhibitor II, NS3694
  • Apoptosis Inhibitor II, NS3694 - CAS 426834-38-0 - Calbiochem
  • Benzoic acid, 4-chloro-2-[[[[3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-
  • NS 3694,Inhibitor,Apaf-1,Apoptosis,inhibit,caspase-9,NS-3694,apoptosome inhibitor,NS3694,cytochrome c
  • 426834-38-0
  • C15H10ClF3N2O3
  • Apoptosis Inhibitors
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