GSA 10

300833-95-8

CAS-Nr.: 300833-95-8

Englisch Name:: GSA 10

Synonyma:: GSA 10;propyl 4-[(1-hexyl-4-hydroxy-2-oxo-quinoline-3-carbonyl)amino]benzoate;Propyl 4-(1-hexyl-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxamido)benzoate;4-[[(1-Hexyl-1,2-dihydro-2-oxo-3-quinolinyl)carbonyl]amino]benzoic acid propyl ester;Benzoic acid, 4-[[(1-hexyl-1,2-dihydro-4-hydroxy-2-oxo-3-quinolinyl)carbonyl]amino]-, propyl ester;Inhibitor,differentiation,regenerative medicine,Smoothened receptor,quinolinecarboxamide derivative,cancer,Smoothened,GSA 10,GSA-10,Smo,osteoblasts,Hedgehog,GSA10,inhibit,multipotent mesenchymal progenitor cell

CBNumber:: CB52716245

Summenformel:: C26H30N2O5

Molgewicht:: 450.53

MOL-Datei:: 300833-95-8.mol

Request For Quotation

Eigenschaften Sicherheit Verwendungswort Produktionsfirma 44

GSA 10 Eigenschaften

Siedepunkt:: 620.2±55.0 °C(Predicted)

Dichte: 1.240±0.06 g/cm3(Predicted)

storage temp.: Store at -20°C

Löslichkeit: Soluble to 5 mM in DMSO with gentle warming

Aggregatzustand: Powder

pka: 4.50±1.00(Predicted)

Sicherheit

Risiko- und Sicherheitserklärung
Gefahreninformationscode (GHS)

Bildanzeige (GHS)

Alarmwort

Warnung

Gefahrenhinweise

Code	Gefahrenhinweise	Gefahrenklasse	Abteilung	Alarmwort	Symbol	P-Code
H302	Gesundheitsschädlich bei Verschlucken.	Akute Toxizität oral	Kategorie 4	Warnung	src="/GHS07.jpg" width="20" height="20" />	P264, P270, P301+P312, P330, P501

Sicherheit

P280	Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P305+P351+P338	BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

GSA 10 Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Smoothened (SMO) is a cell surface receptor that, with Patched, mediates hedgehog signaling to regulate gene expression through the Gli transcription factors. GSA 10 is a quinolinecarboxamide derivative that acts as an agonist of SMO. By acting at SMO, GSA 10 has been shown to promote the differentiation of multipotent mesenchymal progenitor cells into osteoblasts (EC₅₀ = 1.2 μM). Most notably, GSA 10 does not recognize the classic cyclopamine binding site as do other SMO agonists and as such has been used to characterize a novel SMO active site.

Verwenden

GSA 10 is a novel small-molecule positive modulator of smoothened. GSA 10 may have therapeutic interests in regenerative medicine.

GSA 10 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

GSA 10 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 44)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Career Henan Chemica Co	+86-0371-86658258 15093356674;	laboratory@coreychem.com	China	30255	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	52927	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131980	58
Guangzhou Zhiya Chemdrugs Co.,Ltd	18122150900	sculk28@163.com	China	646	55
SPIRO PHARMA		eric_feng1954@126.com	China	9254	55
Pharmacodia (Beijing) Co.,Ltd	+86-400-851-9921	sales@pharmacodia.com	China	2317	55
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9709	58
Shanghai Rechem science Co., Ltd.	21-31433387 15618786686	sales@rechemscience.com	China	2985	58
Lynnchem	86-(0)29-85992781 17792393971	info@lynnchem.com	China	4587	58

Propyl 4-(1-hexyl-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxamido)benzoate
GSA 10
propyl 4-[(1-hexyl-4-hydroxy-2-oxo-quinoline-3-carbonyl)amino]benzoate
4-[[(1-Hexyl-1,2-dihydro-2-oxo-3-quinolinyl)carbonyl]amino]benzoic acid propyl ester
Inhibitor,differentiation,regenerative medicine,Smoothened receptor,quinolinecarboxamide derivative,cancer,Smoothened,GSA 10,GSA-10,Smo,osteoblasts,Hedgehog,GSA10,inhibit,multipotent mesenchymal progenitor cell
Benzoic acid, 4-[[(1-hexyl-1,2-dihydro-4-hydroxy-2-oxo-3-quinolinyl)carbonyl]amino]-, propyl ester
300833-95-8