LDC4297

LDC4297 Struktur
1453834-21-3
CAS-Nr.
1453834-21-3
Englisch Name:
LDC4297
Synonyma:
LDC4297;CS-2540;CS-2539;LDC044297;LDC4297;LDC 4297;LDC4297(LDC044297);N-(2-(1H-Pyrazol-1-yl)benzyl)-8-isopropyl-2-(piperidin-3-yloxy)pyrazolo[1,5-a][1,3,5]triazin-4-amine;Pyrazolo[1,5-a]-1,3,5-triazin-4-amine, 8-(1-methylethyl)-2-(3-piperidinyloxy)-N-[[2-(1H-pyrazol-1-yl)phenyl]methyl]-
CBNumber:
CB53171481
Summenformel:
C23H28N8O
Molgewicht:
432.52
MOL-Datei:
1453834-21-3.mol

LDC4297 Eigenschaften

Dichte
1.37±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
Löslichkeit
DMF:20.0(Max Conc. mg/mL);46.24(Max Conc. mM)
DMSO:40.0(Max Conc. mg/mL);92.48(Max Conc. mM)
Ethanol:20.0(Max Conc. mg/mL);46.24(Max Conc. mM)
Aggregatzustand
A crystalline solid
pka
8.69±0.10(Predicted)

Sicherheit

LDC4297 Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

LDC-4297 is an inhibitor of cyclin-dependent kinase 7 (CDK7; IC50 = <5 nM). It is selective for CDK7 over CDK4, CDK6, and CDK9 (IC50s = >10, >10, and 1.71 μM), however, it also inhibits CDK2 and CDK1 (IC50s = 6.4 and 53.7 nM, respectively). LDC-4297 (10-100 nM) induces apoptosis in A549, HeLa, and HCT116 cancer cells in a concentration-dependent manner. It inhibits human cytomegalovirus (HCMV) replication in human fibroblasts (EC50 = 24.5 nM). LDC-4297 also reduces replication of Herpesviridae, Adenoviridae, Poxviridae, Retroviridae, and Orthomyxoviridae family viruses (EC50s = 0.02-1.13 μM).

Verwenden

Cyclin-dependent protein kinase 7 (CDK7) is involved with a broad range of regulatory roles in cell cycle and transcription, which is essential for viral replication. LDC 4297 is a CDK7 inhibitor that can be used to develop antiviral drugs.

LDC4297 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


LDC4297 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 44)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795
ivan@atkchemical.com China 32686 60
HANGZHOU CLAP TECHNOLOGY CO.,LTD
86-571-88216897,88216896 13588875226
sales@hzclap.com CHINA 6313 58
InvivoChem
+1-708-310-1919 +1-13798911105
sales@invivochem.cn United States 6393 58
TargetMol Chemicals Inc.
+1-781-999-5354
support@targetmol.com United States 19973 58
ShenZhen Trendseen Biological Technology Co.,Ltd.
13417589054
trendseenbio@gmail.com China 11681 58
Wuhan Topule Biopharmaceutical Co., Ltd
+8618327326525
masar@topule.com China 8474 58
Aladdin Scientific
+1-833-552-7181
sales@aladdinsci.com United States 57511 58
Amadis Chemical Company Limited
571-89925085
sales@amadischem.com China 131981 58
Shanghai Boyle Chemical Co., Ltd.
sales@boylechem.com China 2923 55
Shanghai JiYi Biotechnology Co. Ltd. 13621943973
sales@shjiyipharmatech.com China 1166 55

  • LDC4297
  • LDC4297(LDC044297)
  • LDC044297
  • LDC4297;LDC 4297
  • CS-2539
  • CS-2540
  • Pyrazolo[1,5-a]-1,3,5-triazin-4-amine, 8-(1-methylethyl)-2-(3-piperidinyloxy)-N-[[2-(1H-pyrazol-1-yl)phenyl]methyl]-
  • N-(2-(1H-Pyrazol-1-yl)benzyl)-8-isopropyl-2-(piperidin-3-yloxy)pyrazolo[1,5-a][1,3,5]triazin-4-amine
  • 1453834-21-3
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