NEOCARZINOSTATIN Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Neocarzinostatin was found in the culture broth of Streptomyces carzinostaticus by Ishida et al. of Tohoku University in 1957. It showed strong cytotoxicity against sarcoma 180 ascites, tumor cells, and leukemia SN36. Neocarzinostatin was found to be an acidic peptide of Mr 10700, consisting of 109 amino acid residues. Recently the principal agent of anticancer and antibacterial activity in neocarzinostatin was found to be a small molecular chromophore with the peptide component playing a role by stabilizing the chromophore in vivo. Neocarzinostatin is used to treat leukemia and gastric and pancreatic cancer.
Verwenden
Neocarzinostatin from
Streptomyces carzinostaticus has been used:
- as a DNA damaging agent to treat human fibroblast GM0637 cells
- as a radiomimetic antibiotic to induce DNA damage
- in combination with Vγ2Vδ2 T cells to determine the cytotoxicity in ovarian cancer cells
NEOCARZINOSTATIN Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
