SMCC crosslinker
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- CAS-Nr.
- 64987-85-5
- Englisch Name:
- SMCC crosslinker
- Synonyma:
- SMCC;2,5-Dioxopyrrolidin-1-yl 4-((2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)Methyl)cyclohexanecarboxylate;NSC 344483;SMCC Crosslinker;N-Succinimidyl 4-(maleimidomethyl)cyclohexanecarboxylate, SMCC;LKA;R3-RM1;SMCC，98%;25MG/100MG/10G;N-SucciniMidyl 4-(N-MaleiMi
- CBNumber:
- CB6748487
- Summenformel:
- C16H18N2O6
- Molgewicht:
- 334.32
- MOL-Datei:
- 64987-85-5.mol
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SMCC crosslinker Eigenschaften
- Schmelzpunkt:
- 180-182 °C (lit.)
- Siedepunkt:
- 501.7±42.0 °C(Predicted)
- Dichte
- 1.42±0.1 g/cm3(Predicted)
- storage temp.
- -20°C
- Löslichkeit
- chloroform: 50 mg/mL
- Aggregatzustand
- powder
- pka
- -2.24±0.20(Predicted)
- Farbe
- White to Off-White
- Sensitive
- Moisture & Light Sensitive
- BRN
- 1555271
- InChI
- InChI=1S/C16H18N2O6/c19-12-5-6-13(20)17(12)9-10-1-3-11(4-2-10)16(23)24-18-14(21)7-8-15(18)22/h5-6,10-11H,1-4,7-9H2
- InChIKey
- JJAHTWIKCUJRDK-UHFFFAOYSA-N
- SMILES
- C1(C(ON2C(=O)CCC2=O)=O)CCC(CN2C(=O)C=CC2=O)CC1
- CAS Datenbank
- 64987-85-5(CAS DataBase Reference)
SMCC crosslinker Chemische Eigenschaften,Einsatz,Produktion Methoden
R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
SMCC crosslinker is a hetero-bifunctional crosslinker that contain N-hydroxysuccinimide (NHS) ester and maleimide groups that allow covalent conjugation of amine- and sulfhydryl-containing molecules. SMCC crosslinker must be dissolved in an organic solvent, such as DMSO or DMF, and then can be added to an aqueous crosslinking reaction. SMCC crosslinking reagent is permeable across the lipid bilayer of the cell membrane and can be used to crosslink intracellular proteins and peptides.
Chemische Eigenschaften
White Crystalline Solid
Verwenden
A sulfhydryl and amino reactive heterobifunctional protein crosslinking reagent. It conjugates anti-digoxin F(abTaIII)2 fragments to l-B-galactosidase. Conjugates hIgG to alkaline phosphatase.Spacer Arm: 11.6 Angstroms.
Definition
ChEBI: Succinimidyl 4-(N-maleimidomethyl)cyclohexane-1-carboxylate is an N-hydroxysuccinimide ester derived from 4-(N-maleimidomethyl)cyclohexane-1-carboxylic acid. It is a member of maleimides and a N-hydroxysuccinimide ester.
Allgemeine Beschreibung
4-(
N-Maleimidomethyl)cyclohexanecarboxylic acid
N-hydroxysuccinimide ester (SMCC) is a heterobifunctional cross-linking reagent incorporating an extended spacer with amine and sulfhydryl reactivity. It is typically coupled initially to molecules containing primary amine by amide bond buffered at pH 7.5 (6.5-8.5). The second coupling is specific for molecules containing free sulfhydryl by thioether linkage buffered at pH 6.8 (6.5-7.0). SMCC contains nine atom linker. An extended aliphatic spacer stabilizes the maleimide prior to coupling compared to aromatic spacers.
Chemische Reaktivität
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC) is a non-cleavable and membrane permeable crosslinker. It contains an amine-reactive N -hydroxysuccinimide (NHS ester) and a sulfhydryl-reactive maleimide group. NHS esters react with primary amines at pH 7-9 to form stable amide bonds. Maleimides react with sulfhydryl groups at pH 6.5-7.5 to form stable thioether bonds. The maleimide groups of SMCC and Sulfo-SMCC and are unusually stable up to pH 7.5 because of the cyclohexane bridge in the spacer arm.
SMCC crosslinker Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
SMCC crosslinker Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 259)Lieferanten
64987-85-5()Verwandte Suche:
- SMCC [4-(N-Maleimidomethyl)cyclohexanecarboxylic acid N-hydroxysuccinimide ester]
- trans-4-(Maleimidomethyl)-cyclohexane carboxylic acid-NHS ester
- N-SucciniMidyl 4-(N-MaleiMidoMethyl)cyclohexanecarboxylate
- 4-(N-MaleiMidoMethyl)cyclohexane-1-carboxylic acid N-hydroxysucciniMide ester, 98+%
- 4-(N-Maleimidomethyl)cyclohexanecarboxylic Acid N-Succinimidyl Ester
SMCC
- 25MG/100MG/10G
- SMCC N-SucciniMidyl 4-(N-MaleiMidoMethyl)cyclohexane-1-carboxylate
- N-SucciniMidyl 4-(MaleiMidoMethyl)cyclohexane-1-carboxylate(SMCC)
- 4-(MaleiMidoMethyl)cyclohexane-1-carboxylic acid N-hydroxysucciniMide ester, 98+%
- N-SucciniMidyl 4-(N-MaleiMi
- SucciniMidyl-4-(N-MaleiMidoMethyl)cyclohexane-1-carboxylate (SMCC)
- N-SucciniMidyl 4-(N-MaleiMidoMethyl)cyclohexanecarboxylate , 98.0%(LC)
- N-Succinimidyl 4-(N-maleimidomethyl)cyclohexane-
- N-Succinimidyl 4-(N-Maleimidomethyl)cyclohexanecarboxylate
- 4-(N-MALEIMIDOMETHYL)CYCLOHEXANE-1-*
- 2,5-Dioxopyrrolidin-1-yl 4-((2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)methyl)cyclohexanecarboxylat
- n-(4-carboxycyclohexylmethyl)maleimiden-hydroxysuccinimideester
- SUCCINIMIDYL TRANS-4-(MALEIMIDYLMETHYL)CYCLOHEXANE-1-CARBOXYLATE
- SUCCINIMIDYL-TRANS-4-(N-MALEIMIDOMETHYL)CYCLOHEXANE-1-CARBOXYLATE
- SUCCINIMIDYL-TRANS-4-(N-MALEIMIDYLMETHYL)CYCLOHEXANE-1-CARBOXYLATE
- SUCCINIMIDYL 4-[N-MALEIMIDO-METHYL]CYCLOHEXANE-1-CARBOXYLATE
- N-SUCCINIMIDYL 4-(MALEIMIDOMETHYL)CYCLOHEXANE-1-CARBOXYLATE
- N-SUCCINIMIDYL 4-(MALEIMIDOMETHYL)CYCLOHEXANECARBOXYLATE
- TRANS-4-(N-MALEIMIDYLMETHYL)-CYCLO-HEXANE-1-CARBOXYLATE-N-HYDROXYSUCCINIMIDE ESTER
- 4-(N-MALEIMIDOMETHYL)CYCLOHEXANE-1-CARBOXYLIC ACID N-HYDROXYSUCCINIMIDE ESTER
- 4-(N-MALEIMIDOMETHYL)CYCLOHEXANECARBOXYLIC ACID N-HYDROXYSUCCINIMIDE ESTER
- N-succinimidyl 4-(maleimidome.)cyclo-hexanecarboxylate
- 4-(N-MALEIMIDOMETHYL)-CYCLOHEXANE-1-CARBOXYLIC ACID N-HYDROXYSUCCINIMIDE ESTER CRYSTALLINE
- N-Succinimidyl-4-(N-maleimidomethyl)-cyclohexane-1-carboxylate
- 4-(maleimidomethyl)-1-cyclohexanecarboxylic acid N-hydroxy
- N-Succinimidyl 4-(N-maleimidomethyl)cycl
- 4-(N-maleimidomethyl)cyclohexane-1-carboxylic acid N-succinimidyl ester
- LKA
- 4-(Maleimidomethyl)cyclohexane-1-carboxylic acid N-hydroxysuccinimide ester
- trans-4-(Maleimidomethyl)-cyclohexane carboxylic
- SMCC [4-(N-Maleimidomethyl)cyclohexanecarboxylic acid N-hydroxysuccinimide ester] *CAS 64987-85-5*
- N-Succinimidyl 4-(N-Maleimidomethyl)cyclohexanecarboxylate >
- Cyclohexanecarboxylic acid, 4-[(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)methyl]-, 2,5-dioxo-1-pyrrolidinyl ester
- Succinimidyl 4-(N-maleimidomethyl)cyclohexanecarboxylate
- N-Succinimidyl 4-(N-Maleimidomethyl)cyclohexanecarboxylate (2mg*5)
- 4-(N-Maleimidomethyl)cyclohexanecarboxylic Acid N-Succinimidyl Ester
- 2,5-Dioxopyrrolidin-1-yl 4-[(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)methyl]cyclohexane-1-carboxylate
- R3-RM1
- Succinimidyl-4-(N- (N-maleimidomethyl) cyclohexane-1-carboxylate (SMCC), 98%
- (2,5-dioxopyrrolidin-1-yl) 4-[(2,5-dioxopyrrol-1-yl)methyl]cyclohexane-1-carboxylate
- N-Succinimidyl 4-(maleimidomethyl)cyclohexanecarboxylate, SMCC
- 2,5-Dioxopyrrolidin-1-yl 4-((2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)Methyl)cyclohexanecarboxylate
- SMCC Crosslinker
- SMCC
- NSC 344483
- SMCC，98%
- 4-(N-maleimidyl methyl) cyclohexane-1-carboxylic acid succinimide ester
- N-Succinimidyl-4-[2-(4,4-Dimethoxytrityl)]Butyrate
- SMCC, heterobifunctional cross-linker
- 64987-85-5
- C16H18N2O6
- BioChemical
- Protein Modification
