EzetiMibe-d4

EzetiMibe-d4 Struktur
1093659-89-2
CAS-Nr.
1093659-89-2
Englisch Name:
EzetiMibe-d4
Synonyma:
Ezetimibe-d4-1;[2H4]-Ezetimibe;Ezetimibe Impurity 119;Ezetimibe D4 (4-Fluorophenyl-2,3,5,6-d4);(3R,4S)-1-(4-Fluorophenyl)-3-((S)-3-(4-fluorophenyl-2,3,5,6-d4)-3-hydroxypropyl)-4-(4-hydroxyphenyl)azetidin-2-one;(3R,4S)-3-[(3S)-3-[4-fluoro(2,3,5,6-2H?)phenyl]-3-hydroxypropyl]-1-(4-fluorophenyl)-4-(4-hydroxyphenyl)azetidin-2-one;(3R,4S)-1-(4-fluorophenyl)-4-(4-hydroxyphenyl)-3-[(3S)-3-hydroxy-3-(2,3,5,6-tetradeuterio-4-fluorophenyl)propyl]azetidin-2-one;Ezetimibe D4Q: What is Ezetimibe D4 Q: What is the CAS Number of Ezetimibe D4 Q: What is the storage condition of Ezetimibe D4
CBNumber:
CB72710005
Summenformel:
C24H21F2NO3
Molgewicht:
409.43
MOL-Datei:
1093659-89-2.mol

EzetiMibe-d4 Eigenschaften

storage temp. 
Store at -20°C
Löslichkeit
DMF: Soluble; DMSO: Soluble; Ethanol: Soluble; Methanol: Soluble
Aggregatzustand
A solid
Farbe
White to off-white

Sicherheit

EzetiMibe-d4 Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Ezetimibe-d4 is intended for use as an internal standard for the quantification of ezetimibe by GC- or LC-MS. Ezetimibe inhibits intestinal cholesterol absorption by preventing cholesterol uptake by the Niemann-Pick C1-like 1 (NPC1L1) protein, a cholesterol transporter located in the apical membrane of enterocytes. Upon oral administration ezetimibe undergoes rapid glucuronidation in the intestine where its glucuronide binds NPC1L1. Ezetimibe exhibits ED50 values of 0.0005-0.05 mg/kg in various animal models, selectively blocking cholesterol absorption without inhibiting pancreatic lipolytic enzyme activities in the intestinal lumen, affecting bile acid micelle solubilization of cholesterol, or interfering with the absorption of triglycerides, fatty acids, or bile acids.

Verwenden

Ezetimibe-d4 is the labeled analogue of Ezetimibe (E975000), an antihyperlipoproteinemic. A cholesterol absorption inhibitor.

EzetiMibe-d4 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


EzetiMibe-d4 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 32)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
BOC Sciences
+1-631-485-4226
inquiry@bocsci.com United States 19553 58
Aladdin Scientific
+1-+1(833)-552-7181
sales@aladdinsci.com United States 52925 58
J & K SCIENTIFIC LTD. 010-82848833 400-666-7788
jkinfo@jkchemical.com China 94657 76
Chemsky(shanghai)International Co.,Ltd. 021-50135380
shchemsky@sina.com China 32321 50
Cato Research Chemicals Inc. 020-81960175
min.he@cato-chem.com China 1955 55
ChemStrong Scientific Co.,Ltd 0755-0755-66853366 13670046396
sales@chem-strong.com China 18044 56
Artis Biotech Co. Ltd. 0575-18780151478 18582380095
sales@artisbio.com China 2965 58
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627
info@efebio.com China 9806 58
Chengdu Novel Biomedical Co., Ltd. 028-85255396 18302801538
cdnovell@163.com China 2304 58
Shenzhen Polymeri Biochemical Technology Co., Ltd. +86-400-002-6226 +86-13028896684;
sales@rrkchem.com China 56533 58

1093659-89-2()Verwandte Suche:


  • (3R,4S)-1-(4-fluorophenyl)-4-(4-hydroxyphenyl)-3-[(3S)-3-hydroxy-3-(2,3,5,6-tetradeuterio-4-fluorophenyl)propyl]azetidin-2-one
  • [2H4]-Ezetimibe
  • Ezetimibe Impurity 119
  • Ezetimibe D4Q: What is Ezetimibe D4 Q: What is the CAS Number of Ezetimibe D4 Q: What is the storage condition of Ezetimibe D4
  • Ezetimibe-d4-1
  • Ezetimibe D4 (4-Fluorophenyl-2,3,5,6-d4)
  • (3R,4S)-1-(4-Fluorophenyl)-3-((S)-3-(4-fluorophenyl-2,3,5,6-d4)-3-hydroxypropyl)-4-(4-hydroxyphenyl)azetidin-2-one
  • (3R,4S)-3-[(3S)-3-[4-fluoro(2,3,5,6-2H?)phenyl]-3-hydroxypropyl]-1-(4-fluorophenyl)-4-(4-hydroxyphenyl)azetidin-2-one
  • 1093659-89-2
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