Adaptaquin

385786-48-1

CAS-Nr.: 385786-48-1

Englisch Name:: Adaptaquin

Synonyma:: Adaptaquin;HIF Prolyl Hydroxylase Inhibitor - CAS 385786-48-1 - Calbiochem;7-[(4-Chlorophenyl)[(3-hydroxy-2-pyridinyl)amino]methyl]-8-quinolinol;7-((4-Chlorophenyl)((3-hydroxypyridin-2-yl)amino)methyl)quinolin-8-ol;8-Quinolinol, 7-[(4-chlorophenyl)[(3-hydroxy-2-pyridinyl)amino]methyl]-;Hypoxia-inducible factors,peroxidation,mitochondrial,HIFs,HIF-PH,inhibit,HIF-PHD2,HIF/HIF Prolyl-Hydroxylase,Adaptaquin,Inhibitor

CBNumber:: CB74665884

Summenformel:: C21H16ClN3O2

Molgewicht:: 377.82

MOL-Datei:: 385786-48-1.mol

Request For Quotation

Eigenschaften Sicherheit Verwendungswort Produktionsfirma 27

Adaptaquin Eigenschaften

Siedepunkt:: 650.9±55.0 °C(Predicted)

Dichte: 1.437±0.06 g/cm3(Predicted)

storage temp.: -20C

Löslichkeit: ≤30mg/ml in DMSO;30mg/ml in dimethyl formamide

Aggregatzustand: Tan solid

pka: 4.07±0.50(Predicted)

Sicherheit

Adaptaquin Chemische Eigenschaften,Einsatz,Produktion Methoden

Enzyminhibitor

This brain-penetrant PHD2 inhibitor and antioxidant (FW = 377.82 g/mol; CAS 385786-48-1; Soluble to 100 mM in DMSO), also named 7-[(4chlorophenyl)[(3-hydroxy-2-pyridinyl)amino]methyl]-8-quinolinol, targets Hypoxia-Inducible Factor (or HIF) prolyl hydroxylase-2, a critical regulator of hematopoietic stem cell (HSC) maintenance during steadystate and stress. Indeed, this branched oxyquinoline molecule was named adaptaquin (AQ) to signify its ability to inhibit the HIF-PHDs and activate adaptive responses to hypoxia. Hypoxia is a prominent feature in the maintenance of HSC quiescence and multipotency. Adaptaquin also exhibits neuroprotective effects, enhancing functional recovery in rodent intracerebral hemorrhage models, via inhibition of ATF4 dependent genes.

Adaptaquin Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

Adaptaquin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 27)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	57511	58
WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd.	17702719238 17702719238	sales@sun-shinechem.com	China	918	64
BOC Sciences	1-631-485-4226; 16314854226	info@bocsci.com	United States	14059	65
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9709	58
Tianjin Kailiqi Biotechnology Co., Ltd.	15076683720	klq@cw-bio.com	China	3500	55
DC Chemicals	021-58447131 13564518121	sales@dcchemicals.com	China	9414	58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	18818260767	sales@chemegen.com	China	11289	58
MedBioPharmaceutical Technology Inc	021-69568360 18916172912	order@med-bio.cn	China	8141	58
Changzhou Furuisi Biotechnology Co., Ltd	0519-85524369	3477467573@qq.com	China	8618	58

Adaptaquin
HIF Prolyl Hydroxylase Inhibitor - CAS 385786-48-1 - Calbiochem
7-[(4-Chlorophenyl)[(3-hydroxy-2-pyridinyl)amino]methyl]-8-quinolinol
Hypoxia-inducible factors,peroxidation,mitochondrial,HIFs,HIF-PH,inhibit,HIF-PHD2,HIF/HIF Prolyl-Hydroxylase,Adaptaquin,Inhibitor
8-Quinolinol, 7-[(4-chlorophenyl)[(3-hydroxy-2-pyridinyl)amino]methyl]-
7-((4-Chlorophenyl)((3-hydroxypyridin-2-yl)amino)methyl)quinolin-8-ol
385786-48-1