1-PHENYL-3-H-8-OXA-2,3-DIAZA-CYCLOPENTA[A]INDEN

34823-86-4

CAS-Nr.: 34823-86-4

Englisch Name:: 1-PHENYL-3-H-8-OXA-2,3-DIAZA-CYCLOPENTA[A]INDEN

Synonyma:: GTP-14564;3-PHENYL-1H-BENZOFURO[3,2-C]PYRAZOLE;1H-Benzofuro[3,2-c]pyrazole, 3-phenyl-;1-PHENYL-3-H-8-OXA-2,3-DIAZA-CYCLOPENTA[A]INDEN

CBNumber:: CB8298108

Summenformel:: C15H10N2O

Molgewicht:: 234.25

MOL-Datei:: 34823-86-4.mol

Request For Quotation

Eigenschaften Sicherheit Verwendungswort Produktionsfirma 46

1-PHENYL-3-H-8-OXA-2,3-DIAZA-CYCLOPENTA[A]INDEN Eigenschaften

Schmelzpunkt:: 222-223 °C

Siedepunkt:: 459.1±25.0 °C(Predicted)

Dichte: 1.321±0.06 g/cm3(Predicted)

storage temp.: Store at +4°C

Löslichkeit: DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS(pH 7.2) (1:2): 0.3 mg/ml; Ethanol: 1 mg/ml

Aggregatzustand: A crystalline solid

pka: 12.72±0.30(Predicted)

Sicherheit

1-PHENYL-3-H-8-OXA-2,3-DIAZA-CYCLOPENTA[A]INDEN Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

GTP 14564 is an inhibitor of class III receptor tyrosine kinases (IC₅₀s = 0.3 μM for c-Fms, c-Kit, ITD-FLT3 and 1 μM for PDGFRβ). It is without effect against a panel of non-receptor tyrosine and serine/threonine kinases. GTP 14564 blocks the proliferation of leukemia cells stimulated with FLT3 ligand by preventing the activation of STAT5.

Verwenden

GTP 14564 is a class III receptor tyrosine kinase (RTK) inhibitor.

Biologische Aktivität

Potent, selective inhibitor of class III receptor tyrosine kinases (IC 50 values are 0.3 μ M for c-Fms, c-Kit, FLT3 and ITD-FLT3 and 1 μ M for PDGFR β ). Displays no selectivity for ERK1, ERK2, EGFR, MEK1, HER2, Src, Abl, PKC, PKA and Akt (IC50 > 10 μ M). Inhibits FL-dependent proliferation in BaF/ITD-FLT3 cells more potently than BaF/wt-FLT3 cells; anti-leukaemic.

1-PHENYL-3-H-8-OXA-2,3-DIAZA-CYCLOPENTA[A]INDEN Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

1-PHENYL-3-H-8-OXA-2,3-DIAZA-CYCLOPENTA[A]INDEN Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 46)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Hangzhou MolCore BioPharmatech Co.,Ltd.	+86-057181025280; +8617767106207	sales@molcore.com	China	49739	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	57511	58
3B Pharmachem (Wuhan) International Co.,Ltd.	821-50328103-801 18930552037	3bsc@sina.com	China	15848	69
EMMX Biotechnology LLC	888-539-0666	info@emmx.com	United States	8449	60
Tianjin Kailiqi Biotechnology Co., Ltd.	15076683720	klq@cw-bio.com	China	3501	55
Shanghai Rechem science Co., Ltd.	21-31433387 15618786686	sales@rechemscience.com	China	2993	58
Shanghai Hongye Biotechnology Co. Ltd	400-9205774	sales@glpbio.cn	China	6870	58
Changzhou Chenhong Biotechnology Co., Ltd.	0519-85788828 13775037613	sales@chemrenpharm.com	China	3553	58
MedBioPharmaceutical Technology Inc	021-69568360 18916172912	order@med-bio.cn	China	8141	58
Hefei Mokai Pharmaceutical Technology Co., Ltd	18130062233	3362556465@qq.com	China	8000	58