1-PHENYL-3-H-8-OXA-2,3-DIAZA-CYCLOPENTA[A]INDEN
|
|
1-PHENYL-3-H-8-OXA-2,3-DIAZA-CYCLOPENTA[A]INDEN 속성
- 녹는점
- 222-223 °C
- 끓는 점
- 459.1±25.0 °C(Predicted)
- 밀도
- 1.321±0.06 g/cm3(Predicted)
- 저장 조건
- Store at +4°C
- 용해도
- DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS(pH 7.2) (1:2): 0.3 mg/ml; Ethanol: 1 mg/ml
- 물리적 상태
- 결정성 고체
- 산도 계수 (pKa)
- 12.72±0.30(Predicted)
안전
1-PHENYL-3-H-8-OXA-2,3-DIAZA-CYCLOPENTA[A]INDEN C화학적 특성, 용도, 생산
개요
GTP 14564 is an inhibitor of class III receptor tyrosine kinases (IC50s = 0.3 μM for c-Fms, c-Kit, ITD-FLT3 and 1 μM for PDGFRβ). It is without effect against a panel of non-receptor tyrosine and serine/threonine kinases. GTP 14564 blocks the proliferation of leukemia cells stimulated with FLT3 ligand by preventing the activation of STAT5.용도
GTP 14564 is a class III receptor tyrosine kinase (RTK) inhibitor.생물학적 활성
Potent, selective inhibitor of class III receptor tyrosine kinases (IC 50 values are 0.3 μ M for c-Fms, c-Kit, FLT3 and ITD-FLT3 and 1 μ M for PDGFR β ). Displays no selectivity for ERK1, ERK2, EGFR, MEK1, HER2, Src, Abl, PKC, PKA and Akt (IC50 > 10 μ M). Inhibits FL-dependent proliferation in BaF/ITD-FLT3 cells more potently than BaF/wt-FLT3 cells; anti-leukaemic.1-PHENYL-3-H-8-OXA-2,3-DIAZA-CYCLOPENTA[A]INDEN 준비 용품 및 원자재
원자재
준비 용품
1-PHENYL-3-H-8-OXA-2,3-DIAZA-CYCLOPENTA[A]INDEN 공급 업체
글로벌( 46)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 |
sales@molcore.com | China | 49739 | 58 |
| Aladdin Scientific | +1-833-552-7181 |
sales@aladdinsci.com | United States | 57511 | 58 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 |
3bsc@sina.com | China | 15848 | 69 |
| EMMX Biotechnology LLC | 888-539-0666 |
info@emmx.com | United States | 8449 | 60 |
| Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 |
klq@cw-bio.com | China | 3501 | 55 |
| Shanghai Rechem science Co., Ltd. | 21-31433387 15618786686 |
sales@rechemscience.com | China | 2991 | 58 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 |
sales@glpbio.cn | China | 6870 | 58 |
| Changzhou Chenhong Biotechnology Co., Ltd. | 0519-85788828 13775037613 |
sales@chemrenpharm.com | China | 3553 | 58 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 |
order@med-bio.cn | China | 8141 | 58 |
| Hefei Mokai Pharmaceutical Technology Co., Ltd | 18130062233 |
3362556465@qq.com | China | 8000 | 58 |