ceralifimod

891859-12-4

CAS-Nr.: 891859-12-4

Englisch Name:: ceralifimod

Synonyma:: ONO-4641;ceralifimod;Ceralifimod (ONO-4641);Ceralifimod (Synonyms: ONO-4641);3-Azetidinecarboxylic acid, 1-[[3,4-dihydro-6-[(2-methoxy-4-propylphenyl)methoxy]-1-methyl-2-naphthalenyl]methyl]-

CBNumber:: CB83032842

Summenformel:: C27H33NO4

Molgewicht:: 435.56

MOL-Datei:: 891859-12-4.mol

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Eigenschaften Sicherheit Verwendungswort Produktionsfirma 32

ceralifimod Eigenschaften

Siedepunkt:: 595.9±50.0 °C(Predicted)

Dichte: 1.172±0.06 g/cm3(Predicted)

storage temp.: Store at -20°C

Löslichkeit: DMSO:5.0(Max Conc. mg/mL);11.48(Max Conc. mM)

Aggregatzustand: A crystalline solid

pka: 2.71±0.20(Predicted)

Sicherheit

ceralifimod Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Ceralifimod is an agonist of the sphingosine-1-phosphate (S1P) receptors S1P₁ and S1P₅ (K_is = 0.626 and 0.574 nM, respectively). It is selective for S1P₁ and S1P₅ over S1P_2-4 (K_is = >5,450, >5,630, and 28.8 nM, respectively). Ceralifimod induces calcium influx in CHO-K1 cells overexpressing S1P₁ (EC₅₀ = 1 nM) and cAMP accumulation in CHO-K1 cells overexpressing S1P₁ or S1P₅ (EC₅₀s = 0.027 and 0.33 nM, respectively). In vivo, ceralifimod (0.03 and 0.1 mg/kg) reduces paw edema in a rat model of collagen induced arthritis (CIA). It also delays disease onset and inhibits lymphocyte infiltration of the spinal cord in a rat model of experimental autoimmune encephalomyelitis (EAE) and prevents disease relapse in a non-obese diabetic mouse model of relapsing-remitting EAE.

ceralifimod Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

ceralifimod Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 32)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
Wuhan Topule Biopharmaceutical Co., Ltd	+8618327326525	masar@topule.com	China	8474	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	52927	58
Suzhou ARTK Medchem Co., Ltd.	+86-512-68323967 +86-18015559028	sales1@artkmedchem.com	China	39009	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131980	58
ShangHai Caerulum Pharma Discovery Co., Ltd.	18149758185	sales-cpd@caerulumpharma.com	China	3427	58
Jinan Yaoyan Pharmaceutical Co., Ltd.		jnyaoyan@163.com	China	3069	58
Shanghai Medicil Biomedical Co., Ltd.	021-50822001	marketing@medicilon.com.cn	China	1152	58
Hangzhou Synstar pharmaceutical Technology CO.,Ltd	0571-85361029	synstar518@163.com	China	1991	58

ceralifimod
Ceralifimod (Synonyms: ONO-4641)
ONO-4641
3-Azetidinecarboxylic acid, 1-[[3,4-dihydro-6-[(2-methoxy-4-propylphenyl)methoxy]-1-methyl-2-naphthalenyl]methyl]-
Ceralifimod (ONO-4641)
891859-12-4