4-(2-(3,5-Dihydroxyphenyl)-ethenyl)-1,2-benzoldiol Chemische Eigenschaften,Einsatz,Produktion Methoden
S-Sätze Betriebsanweisung:
S24/25:Berührung mit den Augen und der Haut vermeiden.
Chemische Eigenschaften
yellow to golden or green crystalline powder
Verwenden
A human metabolite of Resveratrol (R150000). Piceatannol is strong anti-oxidant.
Definition
ChEBI: A stilbenol that is trans-stilbene in which one of the phenyl groups is substituted by hydroxy groups at positions 3 and 4, while the other phenyl group is substituted by hydroxy groups at positions 3 and 5.
Allgemeine Beschreibung
A cell-permeable, substrate competitive and reversible plant metabolite that inhibits the activity of rat liver protein kinase A catalytic subunit (IC
50 = 3 μM), PKC (IC
50 = 8 μM), MLCK (IC
50 = 12 μM). In RBL-2H3 cells, the selective inhibition of Syk by piceatannol results in inhibition of FceR1-mediated signaling. Also inhibits wheat embryo Ca
2+-dependent protein kinase (CDPK) (IC
50 = 19 μM), and p72
syk (IC
50 = 10 μM), a non-receptor tyrosine kinase, relative to Lyn in isolated enzyme preparations. Also possesses anti-leukemic properties. Reported to activate sirtuins and promote the survival of eukaryotic cells.
Biologische Aktivität
Anti-inflammatory, immunomodulatory and antiproliferative agent. Inhibits p56 lck and syk protein tyrosine kinases and inhibits TNF-induced NF- κ B activation and gene expression. Synthesis results from conversion of resveratrol (5-[(1E)-2-(4-Hydroxyphenyl)ethenyl]-1,3,benzenediol ) by cytochrome P450 1B1.
4-(2-(3,5-Dihydroxyphenyl)-ethenyl)-1,2-benzoldiol Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
