Fludroxycortid

Flurandrenolide Struktur
1524-88-5
CAS-Nr.
1524-88-5
Bezeichnung:
Fludroxycortid
Englisch Name:
Flurandrenolide
Synonyma:
33379;haelan;l33379;cordan;drocort;Sermaka;Astonin;cordran;drenison;alondra-f
CBNumber:
CB8420972
Summenformel:
C24H33FO6
Molgewicht:
436.51
MOL-Datei:
1524-88-5.mol

Fludroxycortid Eigenschaften

Schmelzpunkt:
247-255°
alpha 
D +140-150° (CHCl3)
Siedepunkt:
578.7±50.0 °C(Predicted)
Dichte
1.0796 (rough estimate)
Brechungsindex
1.5980 (estimate)
storage temp. 
-20°C Freezer, Under inert atmosphere
Löslichkeit
Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
Aggregatzustand
Solid
pka
12.87±0.10(Predicted)
Farbe
White to Off-White
Wasserlöslichkeit
295mg/L(25 ºC)
EPA chemische Informationen
Fluradrenolide (1524-88-5)
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
WGK Germany  3
RTECS-Nr. TU5024800
HS Code  2937220000
Giftige Stoffe Daten 1524-88-5(Hazardous Substances Data)
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
Sicherheit
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

Fludroxycortid Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

Flurandrenolide (Cordran, Cordran SP) is a synthetic fluorinated corticosteroid.

Indications

Flurandrenolide (Cordran, Cordran SP) is a synthetic fluorinated corticosteroid.

Biologische Funktion

Corticosteroids influence all tissues of the body and produce numerous and varying effects in cells. These steroids regulate carbohydrate, lipid, and protein biosynthesis and metabolism (glucocorticoid effects), and they influence water and electrolyte balance (mineralocorticoid effects). Cortisol is the most potent glucocorticoid secreted by the adrenal gland, and aldosterone is the most potent endogenous mineralocorticoid. Both naturally occurring glucocorticoids and related, semisynthetic analogues can be evaluated in terms of their ability to sustain life, to stimulate an increase in blood glucose concentrations and a deposition of liver glycogen, to decrease circulating eosinophils, and to cause thymus involution in adrenalectomized animals. In addition, corticosteroids can affect immune system functions, inflammatory responses, and cell growth. The primary physiologic function of glucocorticoids is to maintain blood glucose levels and, thus, ensure glucose-dependent processes critical to life, particularly brain functions. Cortisol and related steroids accomplish this by stimulating the formation of glucose, by diminishing glucose use by peripheral tissues, and by promoting glycogen synthesis in the liver to increase carbohydrate stores for later release of glucose.

Allgemeine Beschreibung

Flurandrenolide, 6α-fluoro-11β,21-dihydroxy-16α,17-[(1-methylethylidene)bis(oxy)]pregn-4-ene-3,20-dione, although available as a tape product,can stick to and remove damaged skin, so it should beavoided with vesicular or weeping dermatoses.

Mechanism of action

Glucocorticoid action is mediated through the glucocorticoid receptor, which is found primarily in the cytosol of the cell when not bound to glucocorticoids. The GR is stabilized in the cytosol by complexation with phosphorylated proteins, including a 90-kDa protein referred to as a heat shock protein 90. The steroid molecule binds to the GR, resulting in a conformational change of the receptor to dissociate the other proteins and initiate translocation of the steroid–receptor complex into the nucleus. The steroid–nuclear GR complex interacts with particular HRE regions of the cellular DNA, referred to as glucocorticoid-responsive elements and initiates transcription of the DNA sequence to produce mRNA. Finally, the elevated levels of mRNA lead to increased protein synthesis in the endoplasmic reticulum. These proteins then mediate glucocorticoid effects on carbohydrate, lipid, and protein metabolism. An alternative isoform of the GR has been identified. This isoform of the receptor does not bind known glucocorticoids, and its function remains to be determined.

Clinical Use

Two major uses of glucocorticoids are in the treatment of rheumatoid diseases and allergic manifestations. Their use in the treatment of severe asthma is well documented, as is the utility of glucocorticoids in sepsis and acute respiratory distress syndrome. They are effective in the treatment of rheumatoid arthritis, acute rheumatic fever, bursitis, spontaneous hypoglycemia in children, gout, rheumatoid carditis, sprue, allergy (including contact dermatitis), and other conditions. The treatment of chronic rheumatic diseases and allergic conditions with glucocorticoids is symptomatic and continuous. Symptoms return after withdrawal of the drug.

Nebenwirkungen

Although side effects and toxicities vary with the drug and, sometimes, with the patient, facial mooning, flushing, sweating, acne, thinning of the scalp hair, abdominal distention, and weight gain are observed with most glucocorticoids. Protein depletion (with osteoporosis and spontaneous fractures), myopathy (with weakness of muscles of the thighs, pelvis, and lower back), and aseptic necrosis of the hip and humerus are other side effects.

Fludroxycortid Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Fludroxycortid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 94)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Henan Fengda Chemical Co., Ltd
+86-371-86557731 +86-13613820652
info@fdachem.com China 7845 58
Hubei xin bonus chemical co. LTD
86-13657291602
linda@hubeijusheng.com CHINA 22968 58
career henan chemical co
+86-0371-86658258 15093356674;
factory@coreychem.com China 29826 58
ANHUI WITOP BIOTECH CO., LTD
+8615255079626
eric@witopchemical.com China 23556 58
Shaanxi Dideu Medichem Co. Ltd
+86-029-89586680 +86-18192503167
1026@dideu.com China 9320 58
Dideu Industries Group Limited
+86-29-89586680 +86-15129568250
1026@dideu.com China 29220 58
AFINE CHEMICALS LIMITED
0571-85134551
info@afinechem.com CHINA 15377 58
Dayang Chem (Hangzhou) Co.,Ltd.
571-88938639 +8617705817739
info@dycnchem.com CHINA 52867 58
Henan Alfa Chemical Co., Ltd
+8618339805032
alfa4@alfachem.cn China 12755 58
InvivoChem
+1-708-310-1919 +1-13798911105
sales@invivochem.cn United States 6393 58

1524-88-5(Fludroxycortid)Verwandte Suche:


  • 20-dione,6-alpha-fluoro-11-beta,16-alpha,17,21-tetrahydroxy-pregn-4-ene-cy
  • 20-dione,6alpha-fluoro-11beta,16alpha,17,21-tetrahydroxy-pregn-4-ene-cycli
  • 33379
  • 6alpha-fluoro-11beta,16alpha,17,21-tetrahydroxyprogesteronecyclic16,17-acetal
  • glucocorticoid
  • haelan
  • haldrone-f
  • l33379
  • pregn-4-ene-3,20-dione,6-fluoro-11,21-dihydroxy-16,17-((1-methylethylidene)bis
  • withacetone
  • 6ALPHA-FLUORO-11BETA,16ALPHA,17,21-TETRAHYDROXYPREGN-4-ENE-3,20-DIONE-16,17-ACETONIDE
  • 4-PREGNEN-6-ALPHA-FLUORO-11-BETA, 16-ALPHA, 17,21-TETROL-3,20-DIONE 16,17-ACETONIDE
  • FLUDROXYCORTIDE
  • FLURANDRENOLIDE
  • 6-alpha-fluoro-11-beta,21-dihydroxy-16-alpha,17-alpha-isopropylidenedioxypregn-4-ene-3,20-dione
  • drenison
  • drocort
  • fluorandrenolone
  • fluorandrenoloneacetonide
  • fluoroandrenoloneacetonide
  • flurandrenolone
  • flurandrenoloneacetonide
  • 6α-Fluoro-11β,21-dihydroxy-16α,17α-(isopropylidenedioxy)pregn-4-ene-3,20-dione
  • 6α-Fluoro-16α-hydroxyhydrocortisone 16,17-acetonide
  • Pregn-4-ene-3,20-dione, 6-fluoro-11,21-dihydroxy-16,17-[(1-methylethylidene)bis(oxy)]-, (6α,11β,16α)-
  • Pregn-4-ene-3,20-dione, 6α-fluoro-11β,16α,17,21-tetrahydroxy-, cyclic 16,17-acetal with acetone (7CI, 8CI)
  • Sermaka
  • FLUORANDRENOLIDE
  • 6α-Fluoro-11β,16α,17,21-tetrahydroxypregn-4-ene-3,20-dione 16,17-acetonide
  • 6a-Fluoro-11b,16a,17,21-tetrahydroxypregn-4-ene-3,20-dione 16,17-acetonide
  • Pregn-4-ene-3,20-dione, 6-fluoro-11,21-dihydroxy-16,17-((1-methylethylidene)bis(oxy))-, (6alpha,11beta,16alpha)-
  • Astonin
  • Flurandrenolide,6α-Fluoro-11β,16α,17,21-tetrahydroxypregn-4-ene-3,20-dione 16,17-acetonide
  • Flurandrenolide (100 mg)
  • (6α,11β,16α)-6-Fluoro-11,21-dihydroxy-16,17-[(1-Methylethylidene)bis(oxy)]pregn-4-ene-3,20-dione
  • Fluadrenolone
  • (2S,6aR,6bS,7S,8aS,8bS,11aR,12aS,12bS)-2-fluoro-7-hydroxy-8b-(2-hydroxyacetyl)-6a,8a,10,10-tetraMethyl-5,6,6a,6b,7,8,8a,8b,11a,12,12a,12b-dodecahydro-1H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-4(2H)-one
  • Fludroxycortide Solution, 100ppm
  • Pregn-4-ene-3,20-dione,6-fluoro-11,21-dihydroxy-16,17-[(1-Methylethylidene)bis(oxy)]-, (6a,11b,16a)-
  • 6alpha-fluoro-16alpha-hydroxyhydrocortisone16,17-acetonide
  • acetonideof6alpha-fluoro-16alpha-hydroxyhydrocortisone
  • alondra-f
  • c16,17-acetalwithacetone
  • clic16,17-acetalwithacetone
  • cordan
  • cordran
  • (6alpha,11beta,16alpha)-(oxy))
  • Flunisolide Impurity 1
  • Flurandrenolide USP/EP/BP
  • Flurandrenolide (1.0mg/ml in DMSO)
  • Flurandrenolide (1284000)
  • Riboflavin Impurity 16
  • 4-PREGNEN-6α-FLUORO-11β, 16α, 17, 21-TETROL-3, 20-DIONE 16, 17-ACETONIDE
  • Flurandrenolide (Fludroxycortide
  • 1524-88-5
  • C24H33FO6
  • CORDRAN
  • Intermediates & Fine Chemicals
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