DEACETYLANISOMYCIN FROM STREPTOMYCES*GRISEOLUS

DEACETYLANISOMYCIN FROM STREPTOMYCES*GRISEOLUS Struktur
27958-06-1
CAS-Nr.
27958-06-1
Englisch Name:
DEACETYLANISOMYCIN FROM STREPTOMYCES*GRISEOLUS
Synonyma:
SA 3097D1;deacetylanisomycin;DEACETYLANISOMYCIN FROM STREPTOMYCES*GRISEOLUS;3,4-Pyrrolidinediol, 2-[(4-methoxyphenyl)methyl]-, (2R,3S,4S)-
CBNumber:
CB8498030
Summenformel:
C12H17NO3
Molgewicht:
223.27
MOL-Datei:
27958-06-1.mol

DEACETYLANISOMYCIN FROM STREPTOMYCES*GRISEOLUS Eigenschaften

Schmelzpunkt:
176-179°
alpha 
D25 -20.0° (methanol)
Siedepunkt:
390.7±37.0 °C(Predicted)
Dichte
1.233±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
Löslichkeit
Methanol: soluble
Aggregatzustand
A solid
pka
9.2(at 25℃)

Sicherheit

WGK Germany  3

DEACETYLANISOMYCIN FROM STREPTOMYCES*GRISEOLUS Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Deacetylanisomycin is a derivative of the protein and DNA synthesis inhibitor anisomycin with antimalarial and anticancer activity. It inhibits the growth of the P. falciparum strains K1 and T9-96 in vitro (IC50s = 40.29 and 33.57 μM, respectively). Deacetylanisomycin is cytotoxic to LU99 lung carcinoma and MCF-7 breast cancer cells (IC50s = 23 and 34 μM, respectively). It has been used as a negative control for assessment of protein synthesis inhibitor activity in molluscan neurons.

Verwenden

Deacetylanisomycin is the core structure of a family of dihydroxypyrrolidines produced by several species of Streptomyces. Anisomycin esters are potent inhibitors of protein synthesis. While considered inactive, deacetylanisomycin is a potent growth regulator in plants and its underlying pharmacology is poorly researched. This is all the more significant as anisomycin undergoes facile hydrolysis to deacetylanisomycin in polar solvents in vitro, and in vivo.

DEACETYLANISOMYCIN FROM STREPTOMYCES*GRISEOLUS Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


DEACETYLANISOMYCIN FROM STREPTOMYCES*GRISEOLUS Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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  • SA 3097D1
  • deacetylanisomycin
  • DEACETYLANISOMYCIN FROM STREPTOMYCES*GRISEOLUS
  • 3,4-Pyrrolidinediol, 2-[(4-methoxyphenyl)methyl]-, (2R,3S,4S)-
  • 27958-06-1
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