4-(4-FLUORO-1-NAPHTHALENYL)-6-(1-METHYLETHYL)-2-PYRIMIDINAMINE HYDROCHLORIDE

4-(4-FLUORO-1-NAPHTHALENYL)-6-(1-METHYLETHYL)-2-PYRIMIDINAMINE HYDROCHLORIDE Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

RS 127445 is an orally bioavailable and potent antagonist of the serotonin (5-HT) receptor subtype 5-HT_2B (K_i = 0.32 nM). It is selective for 5-HT_2B over other 5-HT receptor subtypes (K_i = >3 μM for 5-HT_1A, 5-HT_1B, 5-HT_2A, 5-HT_2C, 5-HT₃, 5-HT₅, and 5-HT₆). RS 127445 reduces contraction of rat isolated stomach fundus (pA₂ = 9.5) and lowers intracellular increases in calcium (IC₅₀ = 0.04 nM) induced by 5-HT . It also blocks (±)-α-methyl-5-HT-induced relaxation of isolated rat jugular veins (pA₂ = 9.95). RS 127445 (1-30 mg/kg) reduces peristaltic frequency and fecal output in mice in a dose-dependent manner. Systemic administration of RS 127445 (0.16 mg/kg) reduces basal, but not cocaine-induced, dopamine outflow in the nucleus accumbens of rats and decreases hyperlocomotion induced by cocaine (Item Nos. ISO60176 | 16186 | 22165) or quinpirole.

Verwenden

RS-127445 is a 5-HT2B receptor antagonist with modest activity against other 5-HT receptors. Selective 5-HT2B receptor antagonist

Biologische Aktivität

High affinity 5-HT 2B receptor antagonist (pK i = 9.5). Displays 1000-fold selectivity for 5-HT 2B with good bioavailability.

4-(4-FLUORO-1-NAPHTHALENYL)-6-(1-METHYLETHYL)-2-PYRIMIDINAMINE HYDROCHLORIDE Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

4-(4-FLUORO-1-NAPHTHALENYL)-6-(1-METHYLETHYL)-2-PYRIMIDINAMINE HYDROCHLORIDE Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32686	60
Zhejiang ZETian Fine Chemicals Co. LTD	18957127338	stella@zetchem.com	China	2141	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49391	58
career henan chemical co	+86-0371-86658258 15093356674;	factory@coreychem.com	China	29826	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	28200	58
Hefei Hirisun Pharmatech Co., Ltd	+8615056975894	shawn@hirisunpharm.com	CHINA	9923	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
Henan Aochuang Chemical Co.,Ltd.	+86-0371-63689365 +8618638391208	sales@aochuangchem.com	China	9425	58
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58

199864-87-4()Verwandte Suche:

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• 4-(4-FLUORO-1-NAPHTHALENYL)-6-(1-METHYLETHYL)-2-PYRIMIDINAMINE HYDROCHLORIDE
• RS 127445 HYDROCHLORIDE
• 4-(4-Fluoro-1-naphthalenyl)-6-(1-methylethyl)-2-pyrimidinamine
• MT500
• RS127445
• 2-PyriMidinaMine, 4-(4-fluoro-1-naphthalenyl)-6-(1-Methylethyl)-
• 4-(4-Fluoronaphthalen-1-yl)-6-isopropylpyriMidin-2-aMine hydrochloride
• RS-127445HCl
• 4-(4-Fluoronaphthalen-1-yl)-6-isopropylpyrimidin-2-amine
• 2-Amino-4-(4-fluoronaphth-1-yl)-6-isopropylpyrimidine
• RS 127445 hydrochloride,4-(4-Fluoro-1-naphthalenyl)-6-(1-methylethyl)-2-pyrimidinaminehydrochloride
• RS 127
• RS127
• RS-127
• RS-127445;RS 127445;RS127445;RS127;445;RS 127;445;RS-127;445
• Ziprasidone4-(4-FLUORO-1-NAPHTHALENYL)-6-(1-METHYLETHYL)-2-PYRIMIDINAMINE HYDROCHLORIDE
• MT500;MT 500;RS 127445;RS127445;RS127;445;RS 127;445;RS-127;445
• 4-(4-FLUORO-1-NAPHTHALENYL)-6-(1-METHYLETHYL)-2-PYRIMIDINAMINE HYDROCHLORIDE USP/EP/BP
• 445
• 4-(4-fluoronaphthalen-1-yl)-6-propan-2-ylpyrimidin-2-amine
• RS 127445 hydrochlor
• 2,7-Naphthyridin-1(8H)-one
• 199864-87-4
• 199864-87-3
• C17H17ClFN3
• C17H16FN3HCl
• Inhibitors