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Losartan Carboxaldehyde

Losartan Carboxaldehyde Structure
Losartan Carboxaldehyde structure
CAS No.
114798-36-6
Chemical Name:
Losartan Carboxaldehyde
Synonyms
DUP 167;EXP 3179;Losartan Aldehyde;Losartan EP IMpurity K;Losartan Carboxaldehyde;Losartan Impurity K (EP);Losartan Carboxaldehyde-d3;Losartan Related CoMpound C;Losartan USP Related Compound C;Allisartan Isoproxil impurity II
CBNumber:
CB01176401
Molecular Formula:
C22H21ClN6O
Molecular Weight:
420.89
MDL Number:
MFCD00870256
MOL File:
114798-36-6.mol
Last updated:2024-04-01 18:08:31
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Losartan Carboxaldehyde Properties

Melting point 84-86°C
Boiling point 666.7±65.0 °C(Predicted)
Density 1.34±0.1 g/cm3(Predicted)
storage temp. Refrigerator, Under Inert Atmosphere
solubility Chloroform (Slightly), Ethanol (Slightly), Methanol (Slightly)
form Solid
pka 4.16±0.10(Predicted)
color Off-White to Light Yellow
CAS DataBase Reference 114798-36-6
FDA UNII KJ52CU0VV6

SAFETY

Risk and Safety Statements

HS Code  2933290000

Losartan Carboxaldehyde price More Price(16)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 18855 Losartan Carboxaldehyde ≥95% 114798-36-6 1mg $57 2024-03-01 Buy
Cayman Chemical 18855 Losartan Carboxaldehyde ≥95% 114798-36-6 5mg $152 2024-03-01 Buy
Cayman Chemical 18855 Losartan Carboxaldehyde ≥95% 114798-36-6 10mg $249 2024-03-01 Buy
TRC L470505 LosartanCarboxaldehyde 114798-36-6 50mg $670 2021-12-16 Buy
Usbiological 281287 Losartan carboxaldehyde 114798-36-6 2mg $345 2021-12-16 Buy
Product number Packaging Price Buy
18855 1mg $57 Buy
18855 5mg $152 Buy
18855 10mg $249 Buy
L470505 50mg $670 Buy
281287 2mg $345 Buy

Losartan Carboxaldehyde Chemical Properties,Uses,Production

Description

Losartan carboxaldehyde is an intermediate aldehyde metabolite of the angiotensin II type 1 receptor antagonist, losartan . It does not block angiotensin receptors, but instead inhibits endothelial cyclooxygenase (COX)-2 expression, thereby exerting anti-inflammatory actions. At 1 μM in vitro, losartan carboxaldehyde has also been shown to block the upregulation of intercellular adhesion molecule (ICAM)-1 mRNA and COX-dependent generation of thromboxane A2 and prostaglandin F2α . Losartan carboxaldehyde can also act as a partial agonist (EC50 = 17.1 μM) of the insulin-sensitizing peroxisome proliferator-activated receptor γ in vitro.

Chemical Properties

Yellow Solid

Uses

A labelled intermediate in the synthesis of the EXP 3174, a metabolite of Losartan

Uses

A metabolite of Losartan. An intermediate in the synthesis of the EXP 3174

Uses

Losartan carboxaldehyde is an intermediate aldehyde metabolite of the angiotensin II type 1 receptor antagonist, losartan . It does not block angiotensin receptors, but instead inhibits endothelial cyclooxygenase (COX)-2 expression, thereby exerting anti-inflammatory actions. At 1 μM in vitro, losartan carboxaldehyde has also been shown to block the upregulation of intercellular adhesion molecule (ICAM)-1 mRNA and COX-dependent generation of thromboxane A2 and prostaglandin F2α . Losartan carboxaldehyde can also act as a partial agonist (EC50 = 17.1 μM) of the insulin-sensitizing peroxisome proliferator-activated receptor γ in vitro.[Cayman Chemical]

in vitro

losartan is an intermediate aldehyde metabolite of losartan, the angiotensin ii type 1 receptor antagonist. losartan could not block angiotensin receptors, but inhibit the expression of endothelial cyclooxygenase (cox)-2, therefore exerting anti-inflammatory actions. moreover, losartan at 1 μm was able to block the upregulation of icam-1 mrna and cox-dependent generation of thromboxane a2 and prostaglandin f2α [1].

in vivo

in animal stufdy, losartan was infused for 10 days to rats on a normal sodium intake (nna) and rats on a high sodium intake (hna) to suppress endogenous ang ii. although basal plasma renin activity was markedly suppressed in hna rats compared with nna rats, control arterial pressure was not different between nna and hna rats. losartan could decrease arterial pressure from control levels in nna rats on the first day of infusion but had no effect on arterial pressure in hna rats. in addition, by day 10 of losartan infusion, arterial pressure had decreased further from control levels in nna rats but remained unchanged compared with control in hna rats [2].

References

[1] c. kr mer, j. sunkomat, j. witte, et al. angiotensin ii receptor-independent antiinflammatory and antiaggregatory properties of losartan: role of the active metabolite exp3179. circulation research 90(7), 770-776 (2002).
[2] collister jp, hornfeldt bj, osborn jw. hypotensive response to losartan in normal rats. role of ang ii and the area postrema. hypertension. 1996 mar;27(3 pt 2):598-606.
[3] goa kl, wagstaff aj. losartan potassium: a review of its pharmacology, clinical efficacy and tolerability in the management of hypertension. drugs. 1996 may;51(5):820-45.

Losartan Carboxaldehyde synthesis

114798-26-4
114798-36-6
Synthesis of Losartan Carboxaldehyde from Losartan

Losartan Carboxaldehyde Preparation Products And Raw materials

Raw materials

Preparation Products

N-Trityl Losartan Carboxaldehyde

Losartan Carboxaldehyde Suppliers

Global( 78)Suppliers
Supplier Tel Email Country ProdList Advantage
Amadis Chemical Company Limited
571-89925085 sales@amadischem.com China 131981 58
Hangzhou FandaChem Co.,Ltd. 		008657128800458; +8615858145714 fandachem@gmail.com China 9348 55
Standardpharm Co. Ltd. 		86-714-3992388 overseasales1@yongstandards.com United States 14336 58
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19553 58
Zhengzhou Alfa Chemical Co.,Ltd 		+8618530059196 sale04@alfachem.cn China 12468 58
Career Henan Chemica Co 		+86-0371-86658258 15093356674; laboratory@coreychem.com China 30255 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6313 58
sgtlifesciences pvt ltd 		+8617013299288 dj@sgtlifesciences.com China 12382 58
Alfa Chemistry 		+1-5166625404 Info@alfa-chemistry.com United States 21317 58
Nanjing Doge Biomedical Technology Co., Ltd 		+86-25-58227606 +86-15305155328 sales@dogechemical.com China 4128 58
Supplier Advantage
Amadis Chemical Company Limited
58
Hangzhou FandaChem Co.,Ltd. 		55
Standardpharm Co. Ltd. 		58
BOC Sciences 		58
Zhengzhou Alfa Chemical Co.,Ltd 		58
Career Henan Chemica Co 		58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		58
sgtlifesciences pvt ltd 		58
Alfa Chemistry 		58
Nanjing Doge Biomedical Technology Co., Ltd 		58

View Lastest Price from Losartan Carboxaldehyde manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Allisartan Isoproxil Impurity 14 pictures 2024-04-02 Allisartan Isoproxil Impurity 14
114798-36-6
 US $0.00 / mg 10mg 0.98 10g ShenZhen H&D Pharmaceutical Technology Co., LTD
Allisartan Isoproxil Impurity 14 pictures 2024-04-02 Allisartan Isoproxil Impurity 14
114798-36-6
 US $0.00 / mg 10mg 0.98 10g ShenZhen H&D Pharmaceutical Technology Co., LTD

114798-36-6(Losartan Carboxaldehyde)Related Search:

Losartan carboxylic acid N2-Losartanyl-losartan (Losartan IMpurity) Losartan IsoMer IMpurity, PotassiuM Salt 2'-[(1H-Tetrazol-5-yl)biphenyl-4-yl]Methanol N1-Losartanyl-losartan (Losartan IMpurity)
Triphenylmethanol 2-Butyl-4-chloro-5-formylimidazole Losartan Impurity D 5-(4'-((2-butyl-4-chloro-5-(isopropoxymethyl)-1H-imidazol-1-yl)methyl)-[1,1'-biphenyl]-2-yl)-1H-tetrazole (2-BUTYL-5-CHLORO-1H-IMIDAZOL-4-YL)METHANOL
5-[2-(4'-METHYLBIPHENYL)]TETRAZOLE Losartan IMpurity C (Isolosartan) O-Acetyl Losartan Losartan potassium Losartan
Losartan Carboxaldehyde AKOS 91711 AKOS 91707

1of4

2-Butyl-4-chloro-1-[[2(1H-tetrazol-5-yl)[1,1biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxaldehyde DUP 167 EXP 3179 Losartan Carboxaldehyde Discontinued see product # L470505 Losartan Carboxaldehyde 2-(Butyl-d3)-4-chloro-1-[[2(1H-tetrazol-5-yl)[1,1biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxaldehyde Losartan Carboxaldehyde-d3 Losartan EP IMpurity K (LosaratnCarboxaldehyde) Losartan EP IMpurity K Losartan Related CoMpound C Losartan Aldehyde 1-((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-butyl-4-chloro-1H-imidazole-5-carbaldehyde Losartan Related Compound C (2-Butyl-4-chloro-1-[[2''-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H-imi (1370495) Losartan Carboxaldehyde_x000b_Discontinued see product # L470505 Losartan EP Impurity K/ Losartan Related Compound C (Losartan Aldehyde) Allisartan Isoproxil impurity II 1H-Imidazole-5-carboxaldehyde, 2-butyl-4-chloro-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]- Losartan EP Impurity K:Losartan Impurity K Losartan Impurity 11(Losartan EP Impurity K) 2-Butyl-4-chloro-1-[p-(o-1H-tetrazol-5-ylphenyl)benzyl]imidazole-5-formaldehyde Losartan Impurity K (EP) 2-butyl-5-chloro-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]imidazole-4-carbaldehyde Losartan EP Impurity K (Losartan Carboxaldehyde) Losartan USP Related Compound C DuP 167,EXP-3179,DuP-167,Inhibitor,COX,AT1-R–blocking,intermediate aldehyde metabolite,Cyclooxygenase,COX-2,EXP3179,inhibit,EXP 3179,Losartan,Losartan Carboxaldehyde,anti-inflammatory,DuP167 Losartan Potassium EP Impurity K Losartan EP Impurity K (Losartan USP Related Compound C, Losartan Carboxaldehyde) Losartan EP Impurity K Losartan USP RC C 114798-36-6 14798-36-6 C22H21ClN6O Intermediates & Fine Chemicals Isotope Labelled Compounds Metabolites & Impurities Pharmaceuticals Isotope Labeled Compounds