Xanthine
- CAS No.
- 69-89-6
- Chemical Name:
- Xanthine
- Synonyms
- XANTHINE;Xan;Xanthin;ISOXANTHINE;3,7-Dihydro-1H-purine-2,6-dione;7H-xanthine;9H-PURINE-2,6-DIOL;1H-Purine-2,6(3H,7H)-dione;Xanthione;usafcb-17
- CBNumber:
- CB0197999
- Molecular Formula:
- C5H4N4O2
- Molecular Weight:
- 152.11
- MDL Number:
- MFCD00078453
- MOL File:
- 69-89-6.mol
- MSDS File:
- SDS
Melting point | 300 °C |
---|---|
Boiling point | 274.55°C (rough estimate) |
Density | 1.5452 (rough estimate) |
vapor density | 5.3 (vs air) |
refractive index | 1.8500 (estimate) |
storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
solubility | NH4OH: freely soluble |
form | Powder |
pka | pKa 9.95 (Uncertain) |
color | White to slightly yellow |
Odor | Odorless |
Water Solubility | Soluble in water(0.067g/L). |
Merck | 14,10059 |
BRN | 8733 |
InChIKey | LRFVTYWOQMYALW-UHFFFAOYSA-N |
LogP | -0.730 |
CAS DataBase Reference | 69-89-6(CAS DataBase Reference) |
EWG's Food Scores | 1 |
FDA UNII | 1AVZ07U9S7 |
NIST Chemistry Reference | Xanthine(69-89-6) |
EPA Substance Registry System | Xanthine (69-89-6) |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
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Signal word | Warning | |||||||||
Hazard statements | H317-H319 | |||||||||
Precautionary statements | P280-P305+P351+P338 | |||||||||
Hazard Codes | Xi | |||||||||
Risk Statements | 36-43-36/37/38 | |||||||||
Safety Statements | 36/37-37/39-26 | |||||||||
WGK Germany | 3 | |||||||||
RTECS | ZD7700000 | |||||||||
TSCA | Yes | |||||||||
HS Code | 29335990 | |||||||||
NFPA 704 |
|
Xanthine price More Price(43)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | X0626 | Xanthine ≥99.5% (HPLC), purified by recrystallization | 69-89-6 | 5g | $94.6 | 2024-03-01 | Buy |
TCI Chemical | X0004 | Xanthine >98.0%(HPLC) | 69-89-6 | 25g | $65 | 2024-03-01 | Buy |
Alfa Aesar | A11077 | Xanthine, 99% | 69-89-6 | 25g | $84 | 2024-03-01 | Buy |
Alfa Aesar | A11077 | Xanthine, 99% | 69-89-6 | 100g | $207.65 | 2024-03-01 | Buy |
Sigma-Aldrich | X7375 | Xanthine ≥99% | 69-89-6 | 10g | $73.4 | 2024-03-01 | Buy |
Xanthine Chemical Properties,Uses,Production
Chemical Properties
White to off-white crystalline powder
Uses
Xanthine and xanthine oxidase system can be used to produce superoxide radicals.
Uses
2,6-Dihydroxypurine was fund in animal organs, yeast, patatoes, coffee beans, tea. 2,6-Dihydroxypurine can be used to relax and widen certain breathing passages of the lungs. It is also found that a large number of derivatives have adenoside receptor antagonist properties.
Definition
Xanthine: a purine base, C5H4N4O2,found in many organisms.
Definition
A poisonous colorless crystalline organic compound that occurs in blood, coffee beans, potatoes, and urine. It is used as a chemical intermediate.
Origin
Xanthines (1H-purine-2,6(3H,7H)-diones) are purine based natural heterocyclic alkaloids. They were first discovered in 1817 by German chemist Emil Fisher and later the name ‘xanthine’ was coined in 1899[1].
Biological Functions
In fact, xanthine and its derivatives act as intermediate molecules in generation of GMP, GDP and GTP via the salvage pathway inside the cells. In addition, xanthine plays imperative role in catabolism of nucleotides and nucleic acids as xanthine acts as precursor of uric acid. Therefore, xanthine contains similar skeleton as that of purines which forms the building blocks of unit of life i.e. ribonucleotides (RNA) and deoxyribonucleotides (DNA). The structural resemblance with two of the important purine derivatives Adenine and Guanine; makes xanthine a good therapeutic molecule[1].
Synthesis Reference(s)
Chemical and Pharmaceutical Bulletin, 22, p. 1200, 1974 DOI: 10.1248/cpb.22.1200
General Description
Xanthine is a purine that can be produced in the purine metabolic pathway via different precursors:
- Guanine deamination by guanine deaminase
- Hypoxanthine conversion by xanthine oxidoreductase
Biochem/physiol Actions
A high level of xanthine is implicated in metabolic disorders like Lesch-Nyhan syndrome. A xanthine-based biosensor may be useful for detecting xanthine in food and clinical samples. Blood and urine samples of patients with renal failure, gout and xanthinuria show high levels of xanthine.
Purification Methods
The monohydrate separates in a microcrystalline form on slow acidification with acetic acid of a solution of xanthine in dilute NaOH. It is also precipitated by addition of conc NH3 to its solution in hot 2N HCl (charcoal). After washing with H2O and EtOH, it is dehydrated by heating above 125o. Its solubility in H2O is 1 in 14,000parts at 16o and 1 in 1,500parts of boiling H2O, and separates as plates . It has no m, but the perchlorate has m 262-264o [Lister Purines Part II, Fused Pyrimidines Brown Ed, Wiley-Interscience pp252-253 1971, ISBN 0-471-38205-1]. [Beilstein 26 H 447, 26 I 131, 26 II 260, 26 III/IV 2327.]
References
[1] Ahlawat, Jyoti Minakshi Sharma and Chandra S. Pundir. “Advances in xanthine biosensors and sensors: A review.” Enzyme and Microbial Technology 69 1 (2023).
Xanthine Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
1of2
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Hebei Yanxi Chemical Co., Ltd. | +8617531190177 | peter@yan-xi.com | China | 5873 | 58 |
AstaTech(Chengdu) Biopharmaceutical Corp. | +86-02882666559 +86-15884417729 | gjpu@astatech.com.cn | China | 308 | 58 |
Wuhan Fortuna Chemical Co., Ltd | +86-027-59207850 | info@fortunachem.com | China | 5987 | 58 |
Hebei Kingfiner Technology Development Co.Ltd | +86-15532196582 +86-15373005021 | lisa@kingfinertech.com | China | 2990 | 58 |
hebei hongtan Biotechnology Co., Ltd | +86-86-1913198-3935 +8617331935328 | sales03@chemcn.cn | China | 973 | 58 |
Hebei Zhuanglai Chemical Trading Co.,Ltd | +8613343047651 | admin@zlchemi.com | China | 2998 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29798 | 60 |
Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9312 | 55 |
Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3620 | 58 |
career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29888 | 58 |
Related articles
- The relationship between Xanthine and physiological activities
- An increase in xanthine concentration may be a symptom of several physiological diseases.
- Dec 27,2023
View Lastest Price from Xanthine manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-09-23 | 2,6-Dihydroxypurine
69-89-6
|
US $9.90 / kg | 1kg | 99% | 2000kg | hebei hongtan Biotechnology Co., Ltd | ||
2024-09-23 | 2,6-Dihydroxypurine
69-89-6
|
US $80.00 / kg | 1kg | 99.9% | 1000 | hebei hongtan Biotechnology Co., Ltd | ||
2024-09-18 | 2,6-Dihydroxypurine (Xanthine)
69-89-6
|
US $0.00 / Kg/Bag | 1KG | 99%min | 3500kg/month | WUHAN FORTUNA CHEMICAL CO., LTD |
- 2,6-Dihydroxypurine
69-89-6
- US $9.90 / kg
- 99%
- hebei hongtan Biotechnology Co., Ltd
- 2,6-Dihydroxypurine
69-89-6
- US $80.00 / kg
- 99.9%
- hebei hongtan Biotechnology Co., Ltd
- 2,6-Dihydroxypurine (Xanthine)
69-89-6
- US $0.00 / Kg/Bag
- 99%min
- WUHAN FORTUNA CHEMICAL CO., LTD