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Indications and Usage Mechanisms of Action

CAS No. 1190307-88-0
Chemical Name: Sofosbuvir
Synonyms: GS-7977;PSI 7977;Sofosbubir;sofosbuvir;Suofeibuwei;Sophy Bouvet;Sofosbuvir, >=98%;Sofosbuvir,GS-7977;GS-7977/sofosbuvir;sofosbuvir, PSI7977
CBNumber: CB02604350
Molecular Formula: C22H29FN3O9P
Formula Weight: 529.4525242
MOL File: 1190307-88-0.mol
Sofosbuvir Property
density : 1.41

Sofosbuvir Chemical Properties,Usage,Production

Indications and Usage
Sofosbuvir is the world’s first oral drug for treating hepatitis C and was one of the most important new drugs to be approved in the U.S.A in 2013. It was developed by the American Gillard Scientific Company. It eliminates the need for traditional injection drug interferon (IFN) when treating genotype-specific hepatitis C.
Sofosbuvir is used to treat chronic hepatitis C virus (HCV) infections. It is the first safe and effective drug that does not require IFN when treating HCV infections. There are a few different types of HCV infections. According to the type of infection, treatment regimens can include sofosbuvir and ribavirin, or sofosbuvir, ribavirin and pegylated interferon α.
Mechanisms of Action
Sofosbuvir is a type of nucleotide analogue inhibitor. It prevents hepatitis C virus (HCV) from replicating a crucial type of specific protein.
PSI-7977 is a prodrug that is metabolized to the active antiviral agent 2'-deoxy-2'-α-fluoro-β-C-methyluridine-5'-monophosphate and is currently being investigated in phase 3 clinical trials for the t reatment of hepatitis C. Studies have profiled PSI-7977 as a nucleotide inhibitor of hepatitis C virus, exerting selective inhibitory effects towards HCV NS5B polymerase.
ChEBI: A nucleotide conjugate that is used in combination with ledipasvir (under the trade name Harvoni) for the treatment of chronic hepatitis C genotype 1 infection.
PSI-7977 is a phosphoramidate prodrug of PSI-7851, a nucleoside analog that, when phosphorylated, inhibits the RNA-dependent RNA polymerase of hepatitis C virus (EC50 = 92 nM). PSI-7977 is effective in vitro and in vivo.[Cayman Chemical]
Sofosbuvir Preparation Products And Raw materials
Raw materials
Preparation Products
Sofosbuvir Suppliers      Global( 210)Suppliers     
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Nanjing Gold Pharmaceutical Technology Co. Ltd. 025-84209270 15906146951
025-84209270 CHINA 287 55
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Beijing Cooperate Pharmaceutical Co.,Ltd. +86-10-60279497 +86(0)15646567669
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ChongQing Conscience Pharmaceuticals Ltd. +86-023- 68549356 023-68548079
+86-023-68442044 China 28 60
Jinan Kane Pharmaceutical Technology Co., Ltd. 0531-88603458 18678658680
0531-88603458 China 99 55
Zhengzhou Acme Chemical Co., Ltd. 0371-55282655 13346947059
0371-55282655 China 2781 58
AnHui HaiKang Pharmaceutical Co., Ltd. 0556-5800080 13335996519 18155647299
+86 (0556) 5800080 China 112 55
Biyu Biotechnology (Shanghai) Co., ltd 021-26018599 China 302 56
1190307-88-0(Sofosbuvir)Related Search:
AZD-8055 Selumetinib 4-[[4-[[4-[(E)-2-cyanoethenyl]-2,6-dimethyl-phenyl]amino]pyrimidin-2-yl]amino]benzonitrile Daclatasvir (BMS-790052) Etravirine (TMC125) Entinostat D-Arabinonic acid, 2-C-methyl-4,5-O-(1-methylethylidene)-,ethyl ester ((2R,3R,4R)-3-(benzoyloxy)-4-fluoro-4-methyl-5-oxotetrahydrofuran-2-yl)methyl benzoate 2'-deoxy-2'-fluoro-2'-C-methyluridine
1334531-02-8 Sofosbuvir (PSI-7977, GS-7977) Sofosbuvir N-[[P(S),2'R]-2'-Deoxy-2'-fluoro-2'-methyl-P-phenyl-5'-uridylyl]-L-alanine 1-methylethyl ester propan-2-yl (2S)-2-[[[(2R,3R,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-4-fluoro-3-hydroxy-4-methyloxolan-2-yl]methoxy-phenoxyphosphoryl]amino]propanoate Suofeibuwei API Sofosbuvir, >=98% Sofosbubir Inhibitors Sofosbuvir,GS-7977 Liver Disease Series (S)-Isopropyl 2-(((S)-(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-h 1190307-88-0 GS-7977 N-[[P(S),2'R]-2'-Deoxy-2'-fluoro-2'-methyl-P-phenyl-5'-uridylyl]-L-alanine 1-methylethyl ester PSI 7977 C22H29FN3O9P sofosbuvir GS-7977/sofosbuvir sofosbuvir, PSI7977 PSI7977 (S)-isopropyl 2-(((S)-(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyriMidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-Methyltetrahydrofuran-2-yl)Methoxy)(phenoxy)phosphoryl)aMino)propanoate PSI-7977 Discontinued Pharmaceutical intermediate L-Alanine, N-[[P(S),2'R]-2'-deoxy-2'-fluoro-2'-Methyl-P-phenyl-5'-uridylyl]-, 1-Methylethyl ester Sophy Bouvet
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