ChemicalBook Chinese  Japanese  Germany


Oral drug for hepatitis c

CAS No.1190307-88-0
Chemical Name:Sofosbuvir
Synonyms:GS-7977;PSI 7977;sofosbuvir;Sofosbubir;Suofeibuwei;Sophy Bouvet;Sofosbuvir, >=98%;GS-7977/sofosbuvir;Sofosbuvir,GS-7977;sofosbuvir, PSI7977
Molecular Formula:C22H29FN3O9P
Formula Weight:529.4525242
MOL File:1190307-88-0.mol
Sofosbuvir Property
density : 1.41

Sofosbuvir Chemical Properties,Usage,Production

Oral drug for hepatitis c
Sofosbuvir is also called sovaldi, is the world's first oral drug for hepatitis c, was approved one of the most important new drugs in the United States in 2013. When used in a specific therapy for chronic hepatitis c genotype, it can eliminate the traditional injection drug interferon (IFN) in demand, successful developed by the world's largest manufacturer of anti-hiv drugs-gilead sciences company in the United States, its English name is Sofosbuvir, Sovaldi, its global sales peak might exceed $10 billion.
On December 6, 2013, the United States food and drug administration (FDA) approved sofosbuvir (Sovaldi) for the treatment of chronic hepatitis c virus (HCV) infection. Sofosbuvir is first used in the treatment of certain types of HCV infection without the need for safe and effective drugs at the same time the use of interferon.
Hepatitis c is a viral disease that can cause inflammation of the liver, cause liver function abate or liver failure. Most of the patients with HCV infection until liver damage becomes more obvious symptoms, this process may take several years. Some chronic HCV infection, many years later, there will be a scar and cirrhosis of the liver and can cause bleeding, jaundice (eyes or skin yellow), liver ascites, complications such as infection or liver cancer. According to the centers for disease control and prevention of information, about 3.2 million Americans have hepatitis c virus (HCV) infection.
Sofosbuvir is a kind of nucleotide analogue inhibitors, it can block a specific protein, which is required for the hepatitis c virus replication. Sofosbuvir is used as an antiviral combined treatment of chronic HCV infection. There are several different types of HCV infection. Based on the type of patients with HCV infection, treatment may include sofosbuvir, ribavirin or SuoFei wei and polyethylene glycol α. Ribavirin and polyethylene glycol α are also used for the treatment of HCV infection of two drugs.
Sofosbuvir is the third breakthrough treatment qualification awarded by the FDA approved drugs. If the preliminary clinical research evidence to prove that a drugs can provide patients with serious or life-threatening disease with a substantial improvement compared with the existing treatment, so the drug is the sponsor for the drug applied to the FDA for breakthrough treatments.
The United States patent validity: on March 26, 2029 (US patent no.:7964580 and 8334270), April 3, 2025 (US patent no. :7429572 and 8415322).
The above information is compiled by Chemicalbook XiaoNan .
PSI-7977 is a prodrug that is metabolized to the active antiviral agent 2'-deoxy-2'-α-fluoro-β-C-methyluridine-5'-monophosphate and is currently being investigated in phase 3 clinical trials for the t reatment of hepatitis C. Studies have profiled PSI-7977 as a nucleotide inhibitor of hepatitis C virus, exerting selective inhibitory effects towards HCV NS5B polymerase.
ChEBI: A nucleotide conjugate that is used in combination with ledipasvir (under the trade name Harvoni) for the treatment of chronic hepatitis C genotype 1 infection.
PSI-7977 is a phosphoramidate prodrug of PSI-7851, a nucleoside analog that, when phosphorylated, inhibits the RNA-dependent RNA polymerase of hepatitis C virus (EC50 = 92 nM). PSI-7977 is effective in vitro and in vivo.[Cayman Chemical]
Sofosbuvir Preparation Products And Raw materials
Raw materials
Preparation Products
Sofosbuvir Suppliers      Global( 194)Suppliers     
ChongQing Conscience Pharmaceuticals Ltd. +86-023- 68549356 023-68548079+86-023-68442044clive.yang@consciencepharma.comChina 28 60
MedChemexpress LLC 609-228-6898609-228-5909sales@medchemexpress.comUnited States 4802 58
Jinan Kane Pharmaceutical Technology Co., Ltd. 0531-88603458 186786586800531-8860345885633700@qq.comChina 100 55
Zhengzhou Acme Chemical Co., Ltd. 0371-55282655 133469470590371-55282655ssles1@acmechem.cnChina 2781 58
AnHui HaiKang Pharmaceutical Co., Ltd. 0556-5800080 13335996519 18155647299+86 (0556) China 101 55
Biyu Biotechnology (Shanghai) Co., ltd 021-26018599 support@biyubiotech.comChina 301 56
INTERCHEMIE NANJING PHARMATECH CO., LTD 13656237714,QQ:2112369619+86-25-58277383xiaokunfu@126.comChina 118 55
Shanghai Haoyuan Chemexpress Co., Ltd 86-21-5899859086-21-53700326, 86-21-58998590sales@chemexpress.cnChina 11156 61
Beijing Huikang Boyuan Chemical Tech Co., Ltd 010-68862197010-68882204bjhkby@126.comChina 87 61
Shanghai Boyle Chemical Co., Ltd. 86-21-5018059686-21-57758967sales@boylechem.comChina 2771 55
1190307-88-0(Sofosbuvir)Related Search:
AZD-8055 Selumetinib 4-[[4-[[4-[(E)-2-cyanoethenyl]-2,6-dimethyl-phenyl]amino]pyrimidin-2-yl]amino]benzonitrile Daclatasvir (BMS-790052) Etravirine (TMC125) Entinostat D-Arabinonic acid, 2-C-methyl-4,5-O-(1-methylethylidene)-,ethyl ester ((2R,3R,4R)-3-(benzoyloxy)-4-fluoro-4-methyl-5-oxotetrahydrofuran-2-yl)methyl benzoate 2'-deoxy-2'-fluoro-2'-C-methyluridine
1190307-88-0 GS-7977 N-[[P(S),2'R]-2'-Deoxy-2'-fluoro-2'-methyl-P-phenyl-5'-uridylyl]-L-alanine 1-methylethyl ester PSI 7977 C22H29FN3O9P sofosbuvir GS-7977/sofosbuvir sofosbuvir, PSI7977 PSI7977 (S)-isopropyl 2-(((S)-(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyriMidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-Methyltetrahydrofuran-2-yl)Methoxy)(phenoxy)phosphoryl)aMino)propanoate PSI-7977 Discontinued Pharmaceutical intermediate L-Alanine, N-[[P(S),2'R]-2'-deoxy-2'-fluoro-2'-Methyl-P-phenyl-5'-uridylyl]-, 1-Methylethyl ester Sophy Bouvet 1334531-02-8 Sofosbuvir (PSI-7977, GS-7977) Sofosbuvir N-[[P(S),2'R]-2'-Deoxy-2'-fluoro-2'-methyl-P-phenyl-5'-uridylyl]-L-alanine 1-methylethyl ester propan-2-yl (2S)-2-[[[(2R,3R,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-4-fluoro-3-hydroxy-4-methyloxolan-2-yl]methoxy-phenoxyphosphoryl]amino]propanoate Suofeibuwei API Sofosbuvir, >=98% Sofosbubir Inhibitors Sofosbuvir,GS-7977 Liver Disease Series
Copyright 2016 © ChemicalBook. All rights reserved