6-methoxy-1-tetralone
- CAS No.
- 1078-19-9
- Chemical Name:
- 6-methoxy-1-tetralone
- Synonyms
- 6-Methoxy-3,4-dihydronaphthalen-1(2H)-one;6-METHOXY-1-TETRALONE;1(2H)-NAPHTHALENONE, 3,4-DIHYDRO-6-METHOXY-;6-Methoxy;6-METHOXY-3,4-DIHYDRO-2H-NAPHTHALEN-1-ONE;6-Methoxy-3,4-dihydro-1(2H)-naphthalenone;6-METHOXY-1,2,3,4-TETRAHYDRONAPHTHALEN-1-ONE;6-Methoxy-tetalone;6-Methoxy-1-tetraL;6-METHOXY TETRALONE
- CBNumber:
- CB0277174
- Molecular Formula:
- C11H12O2
- Molecular Weight:
- 176.21
- MDL Number:
- MFCD00001695
- MOL File:
- 1078-19-9.mol
- MSDS File:
- SDS
Melting point | 77-79 °C (lit.) |
---|---|
Boiling point | 171 °C/11 mmHg (lit.) |
Density | 1.0558 (rough estimate) |
refractive index | 1.5250 (estimate) |
Flash point | 171°C/11mm |
storage temp. | Sealed in dry,Room Temperature |
form | Fine Crystalline Powder |
color | Yellow to light brown |
PH | 5.96 at 23℃ and 10g/L |
Merck | 14,6000 |
BRN | 972739 |
InChIKey | MNALUTYMBUBKNX-UHFFFAOYSA-N |
CAS DataBase Reference | 1078-19-9(CAS DataBase Reference) |
FDA UNII | IA52U30635 |
NIST Chemistry Reference | 1(2H)-Naphthalenone, 3,4-dihydro-6-methoxy-(1078-19-9) |
EPA Substance Registry System | 1(2H)-Naphthalenone, 3,4-dihydro-6-methoxy- (1078-19-9) |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
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Signal word | Warning | |||||||||
Hazard statements | H302 | |||||||||
Precautionary statements | P261-P284-P301+P312+P330-P304+P340-P342+P311 | |||||||||
Hazard Codes | Xn,Xi | |||||||||
Risk Statements | 22-36/37/38-20/21/22 | |||||||||
Safety Statements | 24/25-36-26 | |||||||||
WGK Germany | 3 | |||||||||
Hazard Note | Irritant | |||||||||
TSCA | Yes | |||||||||
HS Code | 29145000 | |||||||||
NFPA 704 |
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6-methoxy-1-tetralone price More Price(34)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | M25589 | 6-Methoxy-1-tetralone 99% | 1078-19-9 | 25g | $36.66 | 2024-03-01 | Buy |
Sigma-Aldrich | M25589 | 6-Methoxy-1-tetralone 99% | 1078-19-9 | 100g | $99.5 | 2024-03-01 | Buy |
TCI Chemical | M0787 | 6-Methoxy-1-tetralone >99.0%(GC) | 1078-19-9 | 25g | $55 | 2024-03-01 | Buy |
TCI Chemical | M0787 | 6-Methoxy-1-tetralone >99.0%(GC) | 1078-19-9 | 250g | $318 | 2024-03-01 | Buy |
Alfa Aesar | A15967 | 6-Methoxy-1-tetralone, 99% | 1078-19-9 | 5g | $18.65 | 2024-03-01 | Buy |
6-methoxy-1-tetralone Chemical Properties,Uses,Production
Chemical Properties
yellow to light brown fine crystalline powder
Uses
6-Methoxy-1-tetralone is a reagent useful in the synthesis of (2-(furanyl)vinyl)-1-tetralone chalcones which possesses anticancer agents and inducers of apoptosis.
Definition
ChEBI: 6-Methoxy-1-tetralone is a member of tetralins.
Preparation
(1) Reacting anisole with an acylating agent in Lewis acid and a solvent at the temperature of-10-40 ℃ to generate an intermediate 1, wherein the molar ratio of the Lewis acid to the acylating agent to the anisole is 1-10: 1-10: 1, the Lewis acid is selected from one or more of concentrated sulfuric acid, phosphoric acid, polyphosphoric acid, zinc chloride, aluminum trichloride, superacid and heteropoly acid;
(2) the intermediate 1 does not need to be separated, the temperature is raised to 70-120 ℃, and the intermediate 1 continues to react to generate 6-methoxy-1-tetralone;
(3) cooling the reaction product, adding water to stop the reaction, extracting, purifying and desolventizing to obtain a crude product of the 6-methoxy-1-tetralone, and refining the crude product by a solvent to obtain a high-purity product.
Synthesis Reference(s)
Journal of the American Chemical Society, 64, p. 94, 1942 DOI: 10.1021/ja01253a025
Tetrahedron Letters, 9, p. 2917, 1968 DOI: 10.1016/S0040-4039(00)89611-2
Synthesis
The synthesis of 6-methoxy-1-tetralone is as follows:Eaton's reagent (1.00 mL, 5.31 mmol) was added slowly to a stirred solution of methyl 4-(3-methoxyphenyl)butanoate (4; 0.37g, 1.78 mmol) in DCE (1 mL). The resulting mixture was stirred at 75 °C for 2h under N2 atmosphere. Then, the reaction mixture was allowed to reach room temperature, and was poured over ice-water and extracted with EtOAc (3 × 15 mL). The combined organic extracts were washed successively with brine (2 × 15 mL) and H2O (2 × 20 mL), filtered over Na2SO4 and concentrated under reduced pressure. The resulting brownish oil was fractionated by column chromatography (silica gel, EtOAc-hexanes, 1:9) to obtain 6-methoxy-1-tetralone as ayellowish oil; yield: 0.28 g (91%).
6-methoxy-1-tetralone Preparation Products And Raw materials
Raw materials
Preparation Products
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Supplier | Tel | Country | ProdList | Advantage | |
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Nanjing Triumpharm Co.,Ltd | +86-02586182925 +86-15105172550 | info@triumpharm.com | China | 129 | 58 |
Shaanxi Dideu Medichem Co. Ltd | +86-29-81148696 +86-15536356810 | 1022@dideu.com | China | 3878 | 58 |
Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 | sales@hbmojin.com | China | 12446 | 58 |
Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 | sales1@chuanghaibio.com | China | 5882 | 58 |
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD | +8615383190639 | admin@86-ss.com | China | 1000 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29798 | 60 |
Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 18628 | 58 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21667 | 55 |
Shanghai Time Chemicals CO., Ltd. | +86-021-57951555 +8617317452075 | jack.li@time-chemicals.com | China | 1807 | 55 |
Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3012 | 60 |
View Lastest Price from 6-methoxy-1-tetralone manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-09-20 | 6-methoxy-1-tetralone
1078-19-9
|
US $100.00-75.00 / kg | 1kg | 99% | 5000 | HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD | ||
2024-09-19 | 6-methoxy-1-tetralone
1078-19-9
|
US $30.00-10.00 / kg | 10kg | 99% | 100000kg | Hebei Chuanghai Biotechnology Co,.LTD | ||
2024-09-18 | 6-methoxy-1-tetralone
1078-19-9
|
US $0.00 / KG | 1KG | 98%min | 30tons/month | WUHAN FORTUNA CHEMICAL CO., LTD |
- 6-methoxy-1-tetralone
1078-19-9
- US $100.00-75.00 / kg
- 99%
- HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
- 6-methoxy-1-tetralone
1078-19-9
- US $30.00-10.00 / kg
- 99%
- Hebei Chuanghai Biotechnology Co,.LTD
- 6-methoxy-1-tetralone
1078-19-9
- US $0.00 / KG
- 98%min
- WUHAN FORTUNA CHEMICAL CO., LTD
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