UMBELLIFERYL ARACHIDONATE
- CAS No.
- 161180-11-6
- Chemical Name:
- UMBELLIFERYL ARACHIDONATE
- Synonyms
- 7-HC-ARACHIDONATE;UMBELLIFERYL ARACHIDONATE;SFTGFGOBCQCZDY-DOFZRALJSA-N;7-HYDROXYCOUMARINYL ARACHIDONATE;ARACHIDONATE 2-OXO-2H-1-BENZOPYRAN-7-YL ESTER;5Z,8Z,11Z,14Z-EICOSATETRAENOIC ACID 7-HYDROXYCOUMARINYL;7-Hydroxycoumarinyl Arachidonate (Umbelliferyl Arachidonate);5Z,8Z,11Z,14Z-EICOSATETRAENOIC ACID, 2-OXO-2H-1-BENZOPYRAN-7-YL ESTER;5,8,11,14-Eicosatetraenoic acid, 2-oxo-2H-1-benzopyran-7-yl ester, (5Z,8Z,11Z,14Z)-;7-Hydroxycoumarinyl Arachidonate, 5Z,8Z,11Z,14Z-Eicosatetraenoic acid 2-oxo-2H-1-benzopyran-7-yl ester
- CBNumber:
- CB0413202
- Molecular Formula:
- C29H36O4
- Molecular Weight:
- 448.59
- MDL Number:
- MFCD00797670
- MOL File:
- 161180-11-6.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS02,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H225-H319 | |||||||||
| Precautionary statements | P210-P233-P240-P241-P242-P243-P264-P280-P303+P361+P353-P305+P351+P338-P337+P313-P370+P378-P403+P235-P501 | |||||||||
| Hazard Codes | F,Xi | |||||||||
| Risk Statements | 11-36/37/38 | |||||||||
| Safety Statements | 7-16-26-36 | |||||||||
| RIDADR | UN 1170 3/PG 2 | |||||||||
| WGK Germany | 1 | |||||||||
| NFPA 704 |
|
UMBELLIFERYL ARACHIDONATE price More Price(13)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 62910 | 7-hydroxycoumarinyl Arachidonate ≥98% | 161180-11-6 | 5mg | $36 | 2024-03-01 | Buy |
| Cayman Chemical | 62910 | 7-hydroxycoumarinyl Arachidonate ≥98% | 161180-11-6 | 10mg | $66 | 2024-03-01 | Buy |
| Cayman Chemical | 62910 | 7-hydroxycoumarinyl Arachidonate ≥98% | 161180-11-6 | 25mg | $155 | 2024-03-01 | Buy |
| Cayman Chemical | 62910 | 7-hydroxycoumarinyl Arachidonate ≥98% | 161180-11-6 | 50mg | $274 | 2024-03-01 | Buy |
| TRC | H115003 | 7-HC-arachidonate | 161180-11-6 | 25mg | $175 | 2021-12-16 | Buy |
UMBELLIFERYL ARACHIDONATE Chemical Properties,Uses,Production
Uses
7-HC-arachidonate is a PLA2 fluorogenic substrate for use in assays with phospholipid and Ca2+. It is for use with purified enzymes, as this substrate is nonspecific. 7-HC-arachidonate is ideal for drug discovery, HTS, and similar applications.
Uses
7-hydroxycoumarinyl Arachidonate is the arachidonic acid ester of 7-hydroxycoumarin (umbelliferone) and behaves as a substrate for cPLA2. Hydrolysis of 7-hydroxycoumarinyl arachidonate by phospholipase results in the release of the fluorescent compound 7-hydroxycoumarin which can be monitored spectrophotometrically (excitation at 335 nm, emission at 450 nm).
Biological Activity
7-hydroxycoumarinyl-arachidonate (7-hca), a fluorogenic substrate for monoacylglycerol lipase (magl), can be used with magl as a novel fluorescence-based assay to screen small molecule inhibitors of magl.magl protein catalyzed the hydrolysis of 7-hca to generate arachidonic acid and the highly fluorescent 7-hydroxyl coumarin (7-hc). 7-hydroxycoumarin (7-hc) can be monitored spectrophotometrically (excitation at 335 nm, emission at 450 nm). release of 7-hc was measured using a fluorometer. magl protein catalyzed the hydrolysis of 7-hca with an apparent km of 9.8 μm and vmax of 1.7 mmol/min/mg of protein. the assay is specific for magl as assay buffer alone or heat-denatured magl protein showed no significant activity against 7-hca [1]. 7-hydroxycoumarinyl arachidonate is the arachidonic acid ester of 7-hydroxycoumarin (umbelliferone) and can be used as a substrate for cpla2. hydrolysis of 7-hydroxycoumarinyl arachidonate by phospholipase resulted in the release of the fluorescent compound [2,3].
References
[1]. wang y, chanda p, jones p g, et al. a fluorescence-based assay for monoacylglycerol lipase compatible with inhibitor screening[j]. assay and drug development technologies, 2008, 6(3): 387-393.
[2]. huang z, laliberte f, tremblay n m, et al. a continuous fluorescence-based assay for the human high-molecular-weight cytosolic phospholipase a2[j]. analytical biochemistry, 1994, 222(1): 110-115.
[3]. pickard r t, chiou x g, strifler b a, et al. identification of essential residues for the catalytic function of 85-kda cytosolic phospholipase a2 probing the role of histidine, aspartic acid, cysteine, and arginine[j]. journal of biological chemistry, 1996, 271(32): 19225-19231.
UMBELLIFERYL ARACHIDONATE Preparation Products And Raw materials
Raw materials
Preparation Products
UMBELLIFERYL ARACHIDONATE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
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| Shanghai Aladdin Biochemical Technology Co.,Ltd. | +86-18521732826 | market@aladdin-e.com | China | 48467 | 58 |