3-Maleimidopropionic acid
- CAS No.
- 7423-55-4
- Chemical Name:
- 3-Maleimidopropionic acid
- Synonyms
- 3-(2,5-DIOXO-2,5-DIHYDRO-1H-PYRROL-1-YL)PROPANOIC ACID;BMPA;3-(2,5-DIOXO-2,5-DIHYDRO-PYRROL-1-YL)-PROPIONIC ACID;MPA-OH;3-Maleimidopropionic;AKOS BC-0729;Mal-(CH2)2-COOH;n-maleoyl-β-alanine;MALEOYL-BETA-ALA-OH;RARECHEM AL CD 0912
- CBNumber:
- CB1371466
- Molecular Formula:
- C7H7NO4
- Molecular Weight:
- 169.13
- MDL Number:
- MFCD00043030
- MOL File:
- 7423-55-4.mol
| Melting point | 103-106 °C (lit.) |
|---|---|
| Boiling point | 382.5±25.0 °C(Predicted) |
| Density | 1.473±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| pka | 4.18±0.10(Predicted) |
| form | Solid |
| color | White |
| Water Solubility | Soluble in methanol, dimethyl formamide, alcohol and dimethyl sulfoxide. Slightly soluble in water. |
| Sensitive | Moisture Sensitive |
| BRN | 1528952 |
| InChIKey | IUTPJBLLJJNPAJ-UHFFFAOYSA-N |
| CAS DataBase Reference | 7423-55-4(CAS DataBase Reference) |
| FDA UNII | Q5C4V9T6GU |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 10-21 | |||||||||
| HS Code | 29252900 | |||||||||
| NFPA 704 |
|
3-Maleimidopropionic acid price More Price(52)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 394815 | N-Maleoyl-β-alanine 97% | 7423-55-4 | 250mg | $224 | 2024-03-01 | Buy |
| Sigma-Aldrich | 394815 | N-Maleoyl-β-alanine 97% | 7423-55-4 | 1g | $473 | 2024-03-01 | Buy |
| TCI Chemical | M1962 | 3-Maleimidopropionic Acid >97.0%(GC) | 7423-55-4 | 1g | $89 | 2024-03-01 | Buy |
| TCI Chemical | M1962 | 3-Maleimidopropionic Acid >97.0%(GC) | 7423-55-4 | 5g | $303 | 2024-03-01 | Buy |
| Alfa Aesar | H61536 | 3-Maleimidopropionic acid, 95% | 7423-55-4 | 1g | $168 | 2024-03-01 | Buy |
3-Maleimidopropionic acid Chemical Properties,Uses,Production
Description
3-Maleimidopropionic acid contains a maleimide group and a terminal carboxylic acid. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol.
Chemical Properties
White to Pale Yellow Solid
Uses
3-Maleimidopropionic acid is a sulfhydryl reactive heterobifunctional crosslinking reagent.
Application
3-Maleimidopropionic acid (3MP) is a molecule that can be used for the treatment of cancer. 3MP has been shown to inhibit the growth of tumor cells and induce apoptosis. It also inhibits the production of reactive oxygen species, which are produced by cancer cells as a result of chemotherapy. 3MP has potent inhibitory activity against bacterial organisms such as methicillin-resistant Staphylococcus aureus (MRSA) and Clostridium perfringens and antiviral properties against HIV infection. This molecule can also be used in conjunction with monoclonal antibodies or other immunotherapy techniques to improve their efficacy.
General Description
N-Maleoyl-β-alanine (3-maleimidopropanoic acid) is an aliphatic N-substituted maleimide. It is one of the component of the stabilizing solution for EC145 (a folate-targeted vinca alkaloid conjugate) used in rodent pharmacokinetic studies.
Synthesis
An acetic acid solution of maleic anhydride (5.00 g in 50 mL) was added dropwise to an acetic acid solution of β-alanine (4.54 g in 50 mL). The mixture was stirred at room temperature. After 3 h, AcOH (70 mL ) was added and the temperature was raised to 115 °C under stirred overnight. After 1 hour, an orange oil was obtained. The solvent excess was removed under reduced pressure and the product was washed with toluene (3 × 30 mL). The product was then purified by flash chromatography using a silica column (DCM/ethylacetate 9:1) to obtain the white solid 3-Maleimidopropionic acid.
3-Maleimidopropionic acid Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Guanlang Biotechnology Co,.LTD | +8619930503252 | daisy@crovellbio.com | China | 5964 | 58 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3012 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| SHANDONG ZHI SHANG CHEMICAL CO.LTD | +86 18953170293 | sales@sdzschem.com | China | 2931 | 58 |
| Changzhou Ansciep Chemical Co., Ltd. | +86 519 86305871 | sales@ansciepchem.com | CHINA | 4242 | 58 |
| Accela ChemBio Inc. | (+1)-858-699-3322 | info@accelachem.com | United States | 19965 | 58 |
| Chengdu Pukang Biotechnology Co., Ltd | 028-82550498 | export@pu-kang.com | CHINA | 210 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
View Lastest Price from 3-Maleimidopropionic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2023-07-11 | 3-Maleimidopropionic acid
7423-55-4
|
US $9.00 / KG | 1KG | 99.9 | 1 ton | Hebei Guanlang Biotechnology Co,.LTD | |
 |
2021-09-29 | 3-Maleimidopropionic acid
7423-55-4
|
US $0.00 / Kg/Bag | 10g | 98%min HPLC | 100KGS | WUHAN FORTUNA CHEMICAL CO., LTD | |
 |
2021-07-13 | 3-Maleimidopropionic acid
7423-55-4
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd |
-
- 3-Maleimidopropionic acid
7423-55-4
- US $9.00 / KG
- 99.9
- Hebei Guanlang Biotechnology Co,.LTD
-
- 3-Maleimidopropionic acid
7423-55-4
- US $0.00 / Kg/Bag
- 98%min HPLC
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- 3-Maleimidopropionic acid
7423-55-4
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd