Cefacetrile sodium
- CAS No.
- 23239-41-0
- Chemical Name:
- Cefacetrile sodium
- Synonyms
- C12691;BA-36278;Celospor;BA-36278A;Ciba-36278-Ba;CEFACETRILE SODIUM;Cephacetrile sodium;Cefacetrile sodium (JAN);Cefacetrile sodium USP/EP/BP;sodium (6R-trans)-3-(acetoxymethyl)-7-(cyanoacetamido)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
- CBNumber:
- CB1920963
- Molecular Formula:
- C13H12N3NaO6S
- Molecular Weight:
- 361.30565
- MDL Number:
- MFCD01682009
- MOL File:
- 23239-41-0.mol
- MSDS File:
- SDS
| Melting point | >167°C (dec.) |
|---|---|
| storage temp. | Hygroscopic, -20°C Freezer, Under Inert Atmosphere |
| solubility | DMF (Slightly), DMSO (Slightly) |
| form | Solid |
| color | Pale Beige |
| Stability | Hygroscopic |
| FDA UNII | 87TH1FJY1N |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|---|---|
| Signal word | Danger |
| Hazard statements | H317-H335-H319-H315-H334 |
| Precautionary statements | P261-P272-P280-P302+P352-P333+P313-P321-P363-P501-P264-P280-P305+P351+P338-P337+P313P-P261-P285-P304+P341-P342+P311-P501-P264-P280-P302+P352-P321-P332+P313-P362 |
| Toxicity | LD50 in mice (mg/kg): 4500 ± 540 i.v.; 9100 ± 1500 s.c. (Kradolfer) |
Cefacetrile sodium price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | C231505 | CefacetrileSodium | 23239-41-0 | 5mg | $145 | 2021-12-16 | Buy |
| TRC | C231505 | CefacetrileSodium | 23239-41-0 | 50mg | $1165 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0001880 | CEFACETRILE SODIUM 95.00% | 23239-41-0 | 5MG | $502.9 | 2021-12-16 | Buy |
Cefacetrile sodium Chemical Properties,Uses,Production
Description
Cephacetrile was synthesized by Ciba-Geigy in 1970. It shows almost the same activity against gram-negative bacteria as cephalothin, but it has a higher activity against β-lactamaseproducing Escherichia coli. Like cephalothin, it is metabolized partially by deacetylation in vivo. Cephacetrile has been used to treat sepsis and abdominal and respiratory tract infections caused by Staphylococcus, Streptococcus, Escherichia coli, and Klebsiella pneumoniae, but it is gradually being replaced clinically by the newer and more active cephalosporins.
Originator
Celospor,Ciba Geigy,Switz.,1969
Uses
Cefacetrile Sodium is a cephalosporin antibiotic. Antibacterial.
Definition
ChEBI: Cefacetrile sodium is an organic molecular entity.
Manufacturing Process
13.6 g (0.05 mol) of 7-aminocephalosporanic acid are taken up in a mixture
of 150 ml of methylene chloride and 19.5 ml of tributylamine (0.12 mol) and
at 0°C a solution of 8.4 g of cyanoacetylchloride (0.07 mol) in 100 ml of
methylene chloride is stirred in. The bath is then stirred for ? hour at 0°C
and for ? hour at 20°C, the reaction solution is evaporated under vacuum
and the residue taken up in 10% aqueous dipotassium hydrogenphosphate
solution. This aqueous phase is washed with ethyl acetate, acidified to pH 2.0
with concentrated hydrochloric acid and extracted with ethyl acetate.
After having been dried over sodium sulfate and evaporated under vacuum,
this extract gives as a solid residue 14.7 g of crude 7-cyanoacetylamino-cephalosporanic acid which is purified by chromatography on 30 times its own
weight of silica gel. The fractions eluted with chloroform plus acetone (7:3)
furnish a product which crystallizes from acetone plus ether in the form of
needles melting at 168° to 170°C with decomposition.
5.10 g (15 mmol) of 7-cyanoacetyl-aminocephalosporanic acid are suspended in 102 ml of distilled water and converted into the sodium salt by stirring in
dropwise 15 ml of N sodium hydroxide solution.
Therapeutic Function
Antibiotic
Cefacetrile sodium Preparation Products And Raw materials
Raw materials
Preparation Products
Cefacetrile sodium Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49391 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | 1026@dideu.com | China | 9126 | 58 |
| Finetech Industry Limited | +86-27-87465837 +8618971612321 | info@finetechnology-ind.com | China | 9633 | 58 |
| Finetech Industry Limited | 027-87465837 19945049750 | sales@finetechnology-ind.com | China | 9632 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | 029-61856359 18690052321 | 1027@dideu.com | China | 10011 | 58 |
| Supplier | Advantage |
|---|---|
| CONIER CHEM AND PHARMA LIMITED | 58 |
| Shaanxi Dideu Medichem Co. Ltd | 58 |
| Finetech Industry Limited | 58 |
| Finetech Industry Limited | 58 |
| Shaanxi Dideu Medichem Co. Ltd | 58 |