dimebolin
- CAS No.
- 3613-73-8
- Chemical Name:
- dimebolin
- Synonyms
- CS-151;dimebon;Dimebone;dimebolin;Dimeboline;Brn 0622478;Latrepirdine;Preparation-84;DiMebon (latrepirdine);Dimebolin Exclusive
- CBNumber:
- CB21386820
- Molecular Formula:
- C21H25N3
- Molecular Weight:
- 319.44
- MDL Number:
- MFCD00387540
- MOL File:
- 3613-73-8.mol
- MSDS File:
- SDS
| Melting point | 115-116 °C |
|---|---|
| Boiling point | 448.46°C (rough estimate) |
| Density | 1.13 |
| refractive index | 1.6380 (estimate) |
| storage temp. | Store at -20°C |
| solubility | ≤30mg/ml in ethanol;1mg/ml in DMSO;3mg/ml in dimethyl formamide |
| form | crystalline solid |
| pka | 9.05±0.20(Predicted) |
| CAS DataBase Reference | 3613-73-8 |
| EWG's Food Scores | 1 |
| FDA UNII | OD9237K1Z6 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H320-H335 | |||||||||
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 | |||||||||
| NFPA 704 |
|
dimebolin price More Price(13)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 9000556 | Dimebolin ≥98% | 3613-73-8 | 1mg | $21 | 2024-03-01 | Buy |
| Cayman Chemical | 9000556 | Dimebolin ≥98% | 3613-73-8 | 5mg | $89 | 2024-03-01 | Buy |
| Cayman Chemical | 9000556 | Dimebolin ≥98% | 3613-73-8 | 10mg | $157 | 2024-03-01 | Buy |
| Cayman Chemical | 9000556 | Dimebolin ≥98% | 3613-73-8 | 25mg | $341 | 2024-03-01 | Buy |
| Usbiological | 255148 | Dimebon dihydrochloride | 3613-73-8 | 1mg | $360 | 2021-12-16 | Buy |
dimebolin Chemical Properties,Uses,Production
Uses
Non-steroidal anti-inflammatory with analgesic and antipyretic effects
Definition
ChEBI: Latrepirdine is a member of methylpyridines and a pyridoindole. It has a role as a geroprotector.
Biological Activity
dimebolin is an orally-available antihistamine drug with a long history of clinical use in russia [1][2][3][4].dimebolin has been proposed to be useful for treating neurodegenerative disorders, including alzheimer's disease (ad) and huntington's disease (hd). dimebon might exhibit efficacy by blocking nmda receptors or voltage-gated ca2+ channels and by preventing mitochondrial permeability pore transition [3].dimebolin is an orally-available antihistamine drug. dimebon improved survival of cerebellar granule cells during long-term incubation with aβ25-35. dimebolin also blocked potential-dependent ca(2+) entry into neurons by about 20% by blocking l-type ca(2+) channels [4]. in the cerebellum cell culture, dimebolin protected neurons against the neurotoxic action of aβ25-35 with ec50 value of 25 μm. on isolated rat ileum intestine, dimebolin displayed ca2+-blocking properties with ic50 value of 57 μm. dimebon also exhibited anticholinesterase activity with ic50 values of 7.9 μm and 42 μm for butyryl-choline esterase and acetylcholine esterase, respectively [5].in rats treated with the neurotoxin af64a, dimebolin exhibited cognition and memory-enhancing properties. in mice, dimebolin prevented nmda-induced seizures with ec50 value of 42 ± 6 mg/kg [5].
References
[1]. lermontova nn, lukoyanov nv, serkova tp, et al. dimebon improves learning in animals with experimental alzheimer's disease. bull exp biol med. 2000 jun;129(6):544-6.
[2]. doody rs, gavrilova si, sano m, et al. effect of dimebon on cognition, activities of daily living, behaviour, and global function in patients with mild-to-moderate alzheimer's disease: a randomised, double-blind, placebo-controlled study. lancet. 2008 jul 19;372(9634):207-15.
[3]. wu j, li q, bezprozvanny i. evaluation of dimebon in cellular model of huntington's disease. mol neurodegener. 2008 oct 21;3:15.
[4]. lermontova nn, redkozubov ae, shevtsova ef, et al. dimebon and tacrine inhibit neurotoxic action of beta-amyloid in culture and block l-type ca(2+) channels. bull exp biol med. 2001 nov;132(5):1079-83.
[5]. bachurin s, bukatina e, lermontova n, et al. antihistamine agent dimebon as a novel neuroprotector and a cognition enhancer. ann n y acad sci. 2001 jun;939:425-35.
dimebolin Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 | sales@tnjchem.com | China | 34572 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29016 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| Hebei Duling International Trade Co. LTD | +8618032673083 | sales05@hbduling.cn | China | 15744 | 58 |
| Jiangsu shring Biopharma Co., Ltd. | +8613372282299 | sales@shringchem.com | China | 3545 | 58 |
| Hebei Miaoyin Technology Co.,Ltd | +86-17367732028 +86-17367732028 | kathy@hbyinsheng.com | China | 3582 | 58 |
View Lastest Price from dimebolin manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-10-12 | dimebolin
3613-73-8
|
US $1.10 / g | 1g | 99.00% | 100 Tons Min | Dideu Industries Group Limited | |
 |
2020-01-13 | Latrepirdine
3613-73-8
|
US $1.00 / g | 1g | 95-99% | 1ton | Career Henan Chemical Co |
-
- dimebolin
3613-73-8
- US $1.10 / g
- 99.00%
- Dideu Industries Group Limited
-
- Latrepirdine
3613-73-8
- US $1.00 / g
- 95-99%
- Career Henan Chemical Co
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