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Tetrakis(hydroxymethyl)phosphonium chloride

CAS No.
124-64-1
Chemical Name:
Tetrakis(hydroxymethyl)phosphonium chloride
Synonyms
THPC;SQJGLHL;THPS-UPC;meso-THPC;pyrosettkc;nci-c55061;AURORA KA-1157;HISHICOLIN THPC;tetramethylolphosphonium chloride;tetrakis(hydroxymethyl)phosphonium
CBNumber:
CB2166508
Molecular Formula:
C4H12ClO4P
Molecular Weight:
190.56
MDL Number:
MFCD00031687
MOL File:
124-64-1.mol
MSDS File:
SDS
Last updated:2023-12-26 10:26:05

Tetrakis(hydroxymethyl)phosphonium chloride Properties

Melting point 154°C
Boiling point 115°C/760mmHg
Density 1.341 g/mL at 25 °C
vapor pressure 0Pa at 25℃
refractive index n20/D 1.512
pka 6.05[at 20 ℃]
form Solution
color Clear light pink or yellow-green
Water Solubility >=10 g/100 mL at 20 ºC
BRN 3631669
InChI InChI=1S/C4H12O4P.ClH/c5-1-9(2-6,3-7)4-8;/h5-8H,1-4H2;1H/q+1;/p-1
InChIKey AKXUUJCMWZFYMV-UHFFFAOYSA-M
SMILES [P+](CO)(CO)(CO)CO.[Cl-]
LogP -9.8
CAS DataBase Reference 124-64-1(CAS DataBase Reference)
FDA UNII 58WB2XCF8I
EPA Substance Registry System Tetrakis(hydroxymethyl)phosphonium chloride (124-64-1)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictogramsGHS hazard pictogramsGHS hazard pictograms
GHS05,GHS06,GHS08,GHS09
Signal word  Danger
Hazard statements  H290-H301+H311-H314-H317-H360FD-H410
Precautionary statements  P201-P273-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338
Hazard Codes  T,N
Risk Statements  21-25-38-41-42/43-51/53
Safety Statements  22-26-36/37/39-45-60-61-23
RIDADR  UN 2810 6.1/PG 3
WGK Germany  3
RTECS  TA2450000
HazardClass  8
PackingGroup  III
HS Code  29319019
Toxicity mammal (species unspecified),LD50,oral,400mg/kg (400mg/kg),Kobunshi. High Polymers. Vol. 24, Pg. 788, 1975.
NFPA 704
1
3 0

Tetrakis(hydroxymethyl)phosphonium chloride price More Price(11)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 404861 Tetrakis(hydroxymethyl)phosphonium chloride solution 80% in H2O 124-64-1 100ml $75.5 2024-03-01 Buy
Sigma-Aldrich 404861 Tetrakis(hydroxymethyl)phosphonium chloride solution 80% in H2O 124-64-1 500ml $220 2024-03-01 Buy
TCI Chemical T0607 Tetrakis(hydroxymethyl)phosphonium Chloride (ca. 80% in Water) 124-64-1 25mL $19 2021-12-16 Buy
TCI Chemical T0607 Tetrakis(hydroxymethyl)phosphonium Chloride (ca. 80% in Water) 124-64-1 500mL $162 2021-12-16 Buy
TRC T298578 Tetrakis(hydroxymethyl)phosphonium Chloride (ca. 80% in Water) 124-64-1 1mL $45 2021-12-16 Buy
Product number Packaging Price Buy
404861 100ml $75.5 Buy
404861 500ml $220 Buy
T0607 25mL $19 Buy
T0607 500mL $162 Buy
T298578 1mL $45 Buy

Tetrakis(hydroxymethyl)phosphonium chloride Chemical Properties,Uses,Production

Chemical Properties

Clear light pink or yellow-green solution

Uses

Flame-retarding agent for cotton fabrics. May be used in combination with triethylolamine and urea (Roxel process) or with triethanolamine and tris(1-aziridinyl) phosphine oxide.

Uses

Tetrakis(hydroxymethyl)phosphonium chloride solution (80% in H2O) has been used as a reducing agent and stabilizing ligand for the synthesis of gold nanoparticles (AuNPs) from gold(III) chloride trihydrate (HAuCl4.3H2O). It is a tetra-functional, amine-reactive, aqueous crosslinker that can be used for tuning the properties of protein-based hydrogels for 3D cell encapsulation applications.

Definition

A crystalline compound made by the reaction of phosphine, formaldehyde, and hydrochloric acid.

General Description

Clear slightly viscous,colorless to yellow liquid (20% H2O solution).

Air & Water Reactions

Hygroscopic. Water soluble.

Reactivity Profile

Tetrakis(hydroxymethyl)phosphonium chloride reacts vigorously with oxidizers and alkalis. Reacts with cellulose.

Health Hazard

ACUTE/CHRONIC HAZARDS: Tetrakis(hydroxymethyl)phosphonium chloride may be corrosive. When heated to decomposition, it may emit very toxic fumes of POx, hydrogen chloride and bis(chloromethyl)ether. Decomposition of Tetrakis(hydroxymethyl)phosphonium chloride in an aqueous environment may produce phosphine, formaldehyde and hydrogen chloride.

Fire Hazard

Tetrakis(hydroxymethyl)phosphonium chloride is probably combustible.

Flammability and Explosibility

Non flammable

Purification Methods

Crystallise it from AcOH and dry it at 100o in a vacuum. An 80% w/v aqueous solution has d4 1.33 [Reeves J Am Chem Soc 77 3923 1955]. [Beilstein 1 IV 3062.]

50-00-0
124-64-1
Synthesis of Tetrakis(hydroxymethyl)phosphonium chloride from Formaldehyde

Tetrakis(hydroxymethyl)phosphonium chloride Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 249)Suppliers
Supplier Tel Email Country ProdList Advantage
Dayang Chem (Hangzhou) Co.,Ltd.
571-88938639 +8617705817739 info@dycnchem.com CHINA 52867 58
SIMAGCHEM CORP
+86-13806087780 sale@simagchem.com China 17367 58
Chongqing Chuandong Chemical (Group) Co. Ltd.
+86-13637972665 +86-13637972665 wxc@cd1958.com China 81 58
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21691 55
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008657128800458; +8615858145714 fandachem@gmail.com China 9348 55
Hefei TNJ Chemical Industry Co.,Ltd.
+86-0551-65418679 +86-18949832763 info@tnjchem.com China 2989 55
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18871490254 linda@hubeijusheng.com CHINA 28180 58
Xiamen AmoyChem Co., Ltd
+86-592-6051114 +8618959220845 sales@amoychem.com China 6387 58
Hubei xin bonus chemical co. LTD
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CONIER CHEM AND PHARMA LIMITED
+8618523575427 sales@conier.com China 49390 58

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Tetramethyl phosphorus chloride (THPC) pictures 2023-11-28 Tetramethyl phosphorus chloride (THPC)
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US $1300.00 / kg 1400kg 80% 1000Ton/month Chongqing Chuandong Chemical (Group) Co. Ltd.
Tetrakis(hydroxymethyl)phosphonium chloride pictures 2023-09-06 Tetrakis(hydroxymethyl)phosphonium chloride
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US $0.00-0.00 / KG 1KG 99% 500000kg Hebei Guanlang Biotechnology Co., Ltd.
Tetrakis(hydroxymethyl)phosphonium chloride pictures 2023-09-06 Tetrakis(hydroxymethyl)phosphonium chloride
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US $0.00-0.00 / KG 1KG 99% 500000kg Hebei Guanlang Biotechnology Co., Ltd.
TETRA(HYDROXYMETHYL)PHOSPHONIUM CHLORIDE TETRAKIS(HYDROXYMETHYL)PHOSPHONIUM CHLORIDE tetramethylolphosphonium chloride nci-c55061 Phosphonium,tetrakis(hydroxymethyl)-,chloride pyrosettkc tetrakis-(hydroxymethyl)fosfoniumchlorid tetrakis(hydroxymethyl)phosphochloride tetrakis(hydroxymethyl)-phosphoniuchloride tetrakis(hydroxymethyl)phosphonium TETRAKIS(HYDROXYMETHYL)PHOSPHONIUM CHLOR IDE, 80% SOLUTION IN WATER TETRAKIS(HYDROXYMETHYL)PHOSPHONIUM CHLOR IDE, 80% IN H2O Tetrakis(Hydroxymethyl)Phosphorium Chloride TetrakisHydroxymethylPhosphoniumChloride(Thpc) AURORA KA-1157 tetrakis(hydroxymethyl)phosphonium chloride solution HISHICOLIN THPC Tetrakis(hydroxymethyl)phosphonium Chloride (ca. 80% in Water) TETRAKIS(HYDROXYMETHYL)PHOSPHONIUM CHLORIDE, CA. 80% SOLUTION IN WATER meso-THPC TETRAKIS(HYDROXYMETHYL)PHOSPHONIUM CHLORIDE: 80% IN WATER Tetrakis(HydroxyMethyl) PosphoniuM Chloride Tetrakis(hydroxyMethyl)phosphoniuM chloride solution,~80% in H2O PhosphoniuM,tetrakis(hydroxyMethyl)-, chloride (1:1) THPS-UPC Tetrakis(hydroxymethyl)phosphonium chloride, 80% solution in H2O Tetrakis(hydroxymethyl) phosphonium chloride (70-80 % in water) SQJGLHL Tetrakis(hydroxymethyl)phosphanium chloride Tetrakis(hydroxymethyl)phosphonium chloride solution,~8% in H2O THPC Tetramethyl phosphorus chloride (THPC) 124-64-1 124-61-1 24-64-1 HOCH24PCl C4H12O4PClC4H12ClO4P CH2OH4PCl C4H12O4PCl C4H12ClO4P C10H24O12P2 Phosphonium Compounds Synthetic Reagents Phosphonium Salts Phase Transfer Catalysts texitile auxiliary agents Phosphonium Compounds Greener Alternatives: Catalysis Phase Transfer Catalysts Phosphonium Salts Phosphonium Salts