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S-EMCA

S-EMCA Structure
S-EMCA structure
CAS No.
1199796-29-6
Chemical Name:
S-EMCA
Synonyms
S-EMCA;INT-777;CS-1212;INT777,INT 777;INT-777, S-EMCA;6α-Ethyl-23(S)-Methylcholic acid;6a-Ethyl-23(S)-methylcholic acid;Obeticholic Acid Impurity 49(S-EMCA);6alpha-Ethyl-23(S)-methylcholic acid;Acetylcysteine Impurity 49(D-Cysteine)
CBNumber:
CB22667494
Molecular Formula:
C27H46O5
Molecular Weight:
450.65114
MDL Number:
MFCD18837028
MOL File:
1199796-29-6.mol
MSDS File:
SDS
Last updated:2023-05-21 10:59:17
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S-EMCA Properties

Melting point 150-152℃
Boiling point 602.8±55.0 °C(Predicted)
Density 1.128±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMF:30.0(Max Conc. mg/mL);66.57(Max Conc. mM)
DMF:PBS (pH 7.2) (1:1):0.5(Max Conc. mg/mL);1.11(Max Conc. mM)
DMSO:25.5(Max Conc. mg/mL);56.58(Max Conc. mM)
Ethanol:37.5(Max Conc. mg/mL);83.21(Max Conc. mM)
pka 4.80±0.21(Predicted)
form Powder
FDA UNII UTD8BCW6B8

S-EMCA price More Price(16)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 17678 INT-777 ≥95% 1199796-29-6 500μg $121 2024-03-01 Buy
Cayman Chemical 17678 INT-777 ≥95% 1199796-29-6 1mg $230 2024-03-01 Buy
TRC I666630 6α-Ethyl-23(S)-methylcholicAcid 1199796-29-6 25mg $2035 2021-12-16 Buy
ApexBio Technology B4672 INT-777 1199796-29-6 50mg $2250 2021-12-16 Buy
ChemScene CS-3199 INT-777 100.00% 1199796-29-6 100mg $2520 2021-12-16 Buy
Product number Packaging Price Buy
17678 500μg $121 Buy
17678 1mg $230 Buy
I666630 25mg $2035 Buy
B4672 50mg $2250 Buy
CS-3199 100mg $2520 Buy

S-EMCA Chemical Properties,Uses,Production

Uses

INT 777 is an inhibitor of TGR5 receptor, which is a transmembrane G protein-coupled receptor expressed in brown adipose tissue and muscle and activated by bile acid.

S-EMCA synthesis

1227639-47-5
74-88-4
1199796-29-6
Synthesis of S-EMCA from Cholan-24-oic acid, 6-ethyl-3,7,12-tris(methoxymethoxy)-, methyl ester, (3α,5β,6α,7α,12α)- and Iodomethane

S-EMCA Preparation Products And Raw materials

Raw materials

Cholan-24-oic acid, 6-ethyl-3,7,12-tris(methoxymethoxy)-, methyl ester, (3α,5β,6α,7α,12α)- INT-777 (R-enantiomer) Iodomethane

Preparation Products

S-EMCA Suppliers

Global( 50)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
China National Standard Pharmaceutical Corporation Limited 		+8615391658522 overseasales@yongstandards.com China 11927 58
Amadis Chemical Company Limited 		571-89925085 sales@amadischem.com China 131981 58
Haoyuan Chemexpress Co., Ltd. 021-58950125 info@chemexpress.com China 7553 61
MedChemexpress LLC 021-58955995 sales@medchemexpress.cn United States 4863 58
ShangHai Caerulum Pharma Discovery Co., Ltd. 18149758185 sales-cpd@caerulumpharma.com China 3423 58
LETOPHARM LIMITED +86-21-5821 5861 sales@letopharm.com China 2384 58
Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696，15000506266 15000506266 China 4153 55
BOC Sciences 16314854226 info@bocsci.com United States 9926 65
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9709 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
China National Standard Pharmaceutical Corporation Limited 		58
Amadis Chemical Company Limited 		58
Haoyuan Chemexpress Co., Ltd. 61
MedChemexpress LLC 58
ShangHai Caerulum Pharma Discovery Co., Ltd. 58
LETOPHARM LIMITED 58
Shanghai Lollane Biological Technology Co.,Ltd. 55
BOC Sciences 65
Shanghai EFE Biological Technology Co., Ltd. 58
6α-Ethyl-23(S)-Methylcholic acid INT-777 S-EMCA 6alpha-Ethyl-23(S)-methylcholic acid Cholane-23-carboxylic acid, 6-ethyl-3,7,12-trihydroxy-, (3α,5β,6α,7α,12α,23S)- INT-777, S-EMCA CS-1212 6a-Ethyl-23(S)-methylcholic acid INT777,INT 777 Obeticholic Acid Impurity 49(S-EMCA) Acetylcysteine Impurity 49(D-Cysteine) 1199796-29-6