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(2S-cis)-(+)-2,3-Dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one

(2S-cis)-(+)-2,3-Dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one structure

CAS No.: 42399-49-5

Chemical Name:: (2S-cis)-(+)-2,3-Dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one

Synonyms: HYDROXY LACTAM;(2S,3S)-DHMB;96.0%(LC&DiltiazeM IMpurity E;(2S) -cis-hydroxy lactam;CIS(+) HYDROXY DILTIAZEM;(2S,3S)-3-Hydroxy-2-(4-methoxypheny;Diltiazem Hydrochloride EP Impurity E;Des[3-Acetyl-5-(2-dimethylamino)ethyl] Diltiazem;3-hydroxy-2,3-dihydrobenzo[b][1,4]thiazepin-4(5H)-one

CBNumber:: CB2319542

Molecular Formula:: C16H15NO3S

Molecular Weight:: 301.36

MDL Number:: MFCD01321316

MOL File:: 42399-49-5.mol

Last updated:2023-06-08 17:06:37

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(2S-cis)-(+)-2,3-Dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one Properties

Melting point	203-206 °C(lit.)
alpha	112 º (c=0.5 in MeOH)
Boiling point	545.4±50.0 °C(Predicted)
Density	1.2458 (rough estimate)
refractive index	114 ° (C=0.5, MeOH)
storage temp.	Sealed in dry,2-8°C
solubility	DMSO (Slightly), Methanol (Slightly, Sonicated)
pka	12.37±0.40(Predicted)
form	Solid
color	Off-White
InChIKey	LHBHZALHFIQJGJ-CABCVRRESA-N
CAS DataBase Reference	42399-49-5(CAS DataBase Reference)
FDA UNII	6RN4N3305M

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319

Precautionary statements

P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-36

WGK Germany

HS Code

29349990

NFPA 704

	0
2		0

(2S-cis)-(+)-2,3-Dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one price More Price(20)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	D3661	(2S,3S)-(+)-2,3-Dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one >96.0%(HPLC)(N)	42399-49-5	5g	$36	2024-03-01	Buy
TCI Chemical	D3661	(2S,3S)-(+)-2,3-Dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one >96.0%(HPLC)(N)	42399-49-5	25g	$111	2024-03-01	Buy
TRC	D288450	Des[3-Acetyl-5-(2-dimethylamino)ethyl]Diltiazem	42399-49-5	50mg	$80	2021-12-16	Buy
Biosynth Carbosynth	FD21106	Des[3-acetyl-5-(2-dimethylamino)ethyl] diltiazem	42399-49-5	50g	$95	2021-12-16	Buy
Biosynth Carbosynth	FD21106	Des[3-acetyl-5-(2-dimethylamino)ethyl] diltiazem	42399-49-5	25g	$55	2021-12-16	Buy

Product number	Packaging	Price	Buy
D3661	5g	$36	Buy
D3661	25g	$111	Buy
D288450	50mg	$80	Buy
FD21106	50g	$95	Buy
FD21106	25g	$55	Buy

(2S-cis)-(+)-2,3-Dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one Chemical Properties,Uses,Production

Chemical Properties

white to slightly beige powder

Uses

A key intermediate for Diltiazem (D460620) synthesis.

(2S-cis)-(+)-2,3-Dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one Preparation Products And Raw materials

Raw materials

Preparation Products

Diltiazem

(2S-cis)-(+)-2,3-Dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one Suppliers

Global( 193)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	info@dakenam.com	China	15928	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21691	55
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49390	58
career henan chemical co	+86-0371-86658258 15093356674;	factory@coreychem.com	China	29826	58
SIMAGCHEM CORP	+86-13806087780	sale@simagchem.com	China	17367	58
Hefei TNJ Chemical Industry Co.,Ltd.	0551-65418671	sales@tnjchem.com	China	34572	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	29118	58
AFINE CHEMICALS LIMITED	0571-85134551	info@afinechem.com	CHINA	15377	58
Dayang Chem (Hangzhou) Co.,Ltd.	571-88938639 +8617705817739	info@dycnchem.com	CHINA	52867	58

Supplier	Advantage
Shanghai Daken Advanced Materials Co.,Ltd	58
Henan Tianfu Chemical Co.,Ltd.	55
Hubei Jusheng Technology Co.,Ltd.	58
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58
SIMAGCHEM CORP	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
Dideu Industries Group Limited	58
AFINE CHEMICALS LIMITED	58
Dayang Chem (Hangzhou) Co.,Ltd.	58

View Lastest Price from (2S-cis)-(+)-2,3-Dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2021-07-29	(2S-cis)-(+)-2,3-Dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one USP/EP/BP 42399-49-5	US $1.10 / g	1g	99.9%	100 Tons min	Dideu Industries Group Limited
	2020-01-01	(2S-cis)-(+)-2,3-Dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one 42399-49-5	US $1.00 / KG	1KG	99%	200kg	Career Henan Chemical Co

(2S-cis)-(+)-2,3-Dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one USP/EP/BP
42399-49-5
US $1.10 / g
99.9%
Dideu Industries Group Limited

(2S-cis)-(+)-2,3-Dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one
42399-49-5
US $1.00 / KG
99%
Career Henan Chemical Co

42399-49-5((2S-cis)-(+)-2,3-Dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one)Related Search:

CHLOROPHOSPHONAZO III Diltiazem Impurity 3 (2S,3S)-3-(Acetyloxy)-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one 1-oxide N-DESMETHYLDILTIAZEM, HYDROCHLORIDE DESACETYL DILTIAZEM HCL

Diltiazem EP Impurity B Diltiazem EP Impurity C Glycolic acid Hydroxy silicone oil 2-Phenylphenol

Triphenylphosphine Hydroxyapatite 4-Amino-5-chloro-N-(2-(diethylamino)ethyl)-2-methoxybenzamide Methoxyammonium chloride Camptothecin Series--10-hydroxycamptothecin

Phenylacetone (+)-5-[2-(Dimethylamino)ethyl]-cis-2,3-dihydro-3-hydroxy-2-(p-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one acetate (ester) (2S-cis)-(+)-2,3-Dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one

1of4

(2S-CIS)-(+)-2,3-DIHYDRO-3-HYDROXY-2-(4-METHOXYPHENYL)-1,5-BENZOTHIAZEPIN-4(5H)-ONE (2S-cis)-(+)-2,3-Dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one ,99% DiltiazeM IMpurity E 3-hydroxy-2,3-dihydrobenzo[b][1,4]thiazepin-4(5H)-one (2S,3S)-3-Hydroxy-2-(4-methoxyphenyl)-2,3-dihydrobenzo[b][1,4]thiazepin-4(5H)-one (2S,3S)-(+)-2,3-Dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one Des[3-Acetyl-5-(2-dimethylamino)ethyl] Diltiazem 5-benzothiazepin-4(5h)-one,2,3-dihydro-3-hydroxy-2-(4-methoxyphenyl)-(2s-c CIS-2,3-DIHYDRO-3-HYDROXY-2-(4-METHOXYPHENYL)-1,5-BENZOTHIAZEPIN-4(5H)-ONE (2S-CIS)-(+)-DIHYDRO-3-OH-2-(4-MEO-PH)-1 ,5-BENZOTHIAZEPIN-4(5H)-ONE, 98% (2S,3S)-(+)-3-Hydroxy-2-(4'-Methoxyphenyl)-2.3-Dihydro-1,5-Benzothiazepin-4(5H)-One[Cis-(+)-HydroxyLactam] 1,5-Benzothiazepin-4(5H)-one, 2,3-dihydro-3-hydroxy-2-(4-methoxyphenyl)-, (2S-cis) (2S-CIS)-2,3-DIHYDRO-3-HYDROXY-2-(4-METHOXYPHENYL)-1,5-BENZOTHIAZEPIN- (2S)-cis-(+)-2， 3-Dihydro-3-hydroxy-2- (4-methoxyphenyl)-1，5-benzothiazepin- 4(5H)-one (cis-Lactam) (2S,3S)-(+)-2,3-Dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one (2S)-2,3-Dihydro-3β-hydroxy-2β-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one (2S)-2β-(4-Methoxyphenyl)-3β-hydroxy-2,3,4,5-tetrahydro-1,5-benzothiazepine-4-one (2S,3S)-DHMB (2S-cis)-(+)-2,3-Dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one,98% (2S-cis)-(+)-2,3-Dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one(Dilthiazem hydrochloride) 3-hydroxy-2-(4-methoxyphenyl)-3,5-dihydro-2H-1,5-benzothiazepin-4-one (2S,3S)-(+)-2,3-Dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one> (2S,3S)-3-Hydroxy-2-(4-methoxypheny 96.0%(LC& 1,5-Benzothiazepin-4(5H)-one, 2,3-dihydro-3-hydroxy-2-(4-methoxyphenyl)-, (2S,3S)- (2S,3S)-3-hydroxy-2-(4-methoxyphenyl)-2,3,4,5-tet rahydro-1,5-benzothiazepin-4-one (2S,3S)-3-HYDROXY-2-(4-METHOXYPHENYL)-2,3-DIHYDRO-1,5-BENZOTHIAZEPIN- (2S-cis)-(+)-2,3-Dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one USP/EP/BP (2S-cis)-2,3-dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzo... (2S-cis)-(+)-2,3-Dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-b 42399-49-5 HYDROXY LACTAM (2S) -cis-hydroxy lactam Diltiazem Hydrochloride EP Impurity E CIS(+) HYDROXY DILTIAZEM Diltiazem EP Impurity E (2S,3S)-3-Hydroxy-2-(4-methoxyphenyl)-2,3- dihydro-1,5-benzothiazepin-4(5H)-one (2S,3S)-(+)-2,3-Dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one, ≥ 96.0% 42399-49-5 C16H15NO3S Heterocyclic Building Blocks Others Chiral Building Blocks Asymmetric Synthesis Pharmaceutical Intermediates Chiral Building Blocks Heterocyclic Building Blocks Others Heterocycles series INTERMEDIATESOFDILTIAZEM API intermediates Aromatics Chiral Reagents Intermediates & Fine Chemicals Pharmaceuticals Sulfur & Selenium Compounds