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3,4-Dimethoxyphenol

3,4-Dimethoxyphenol Structure
3,4-Dimethoxyphenol structure
CAS No.
2033-89-8
Chemical Name:
3,4-Dimethoxyphenol
Synonyms
NSC 140927;3,4-Dimethoxyphel;4-HYDROXYVERATROLE;3,4-DIMETHOXYPHENOL;3,4-dimethoxy-pheno;3,4-diMethoxyphenoxyl;Phenol, 3,4-dimethoxy-;3,4-Dimethoxyphenol,97%;3,4-Dimethoxyphenol >3,4-Bis(Methyloxy)phenol
CBNumber:
CB2354549
Molecular Formula:
C8H10O3
Molecular Weight:
154.16
MDL Number:
MFCD00008390
MOL File:
2033-89-8.mol
MSDS File:
SDS
Last updated:2024-09-19 18:11:18
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3,4-Dimethoxyphenol Properties

Melting point 79-82 °C (lit.)
Boiling point 167°C/14mm
Density 1.1690 (rough estimate)
refractive index 1.4740 (estimate)
Flash point 167°C/14mm
storage temp. Keep in dark place,Inert atmosphere,Room temperature
solubility Chloroform (Slightly), Methanol (Slightly)
pka 10.08±0.18(Predicted)
form Fine Crystalline Powder
color Off-white to light beige
Water Solubility Soluble in water.
Sensitive Light Sensitive
BRN 1366650
LogP 1.157 (est)
CAS DataBase Reference 2033-89-8(CAS DataBase Reference)
FDA UNII 38B43WCU83
NIST Chemistry Reference Phenol, 3,4-dimethoxy-(2033-89-8)
EPA Substance Registry System 3,4-Dimethoxyphenol (2033-89-8)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P302+P352-P305+P351+P338
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36-37/39
WGK Germany  3
F  10
TSCA  Yes
HS Code  29095000
NFPA 704
1
2 0

3,4-Dimethoxyphenol price More Price(45)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 194468 3,4-Dimethoxyphenol 97% 2033-89-8 10g $176 2024-03-01 Buy
TCI Chemical D3221 3,4-Dimethoxyphenol >97.0%(GC) 2033-89-8 5g $97 2024-03-01 Buy
TCI Chemical D3221 3,4-Dimethoxyphenol >97.0%(GC) 2033-89-8 25g $330 2024-03-01 Buy
Alfa Aesar A11344 3,4-Dimethoxyphenol, 98% 2033-89-8 5g $96.4 2024-03-01 Buy
Alfa Aesar A11344 3,4-Dimethoxyphenol, 98% 2033-89-8 25g $357.65 2024-03-01 Buy
Product number Packaging Price Buy
194468 10g $176 Buy
D3221 5g $97 Buy
D3221 25g $330 Buy
A11344 5g $96.4 Buy
A11344 25g $357.65 Buy

3,4-Dimethoxyphenol Chemical Properties,Uses,Production

Chemical Properties

Red Crystal Powder

Uses

A substituted alkynyl phenoxy compound as new synergists in pesticidal compositions.

Uses

3,4-Dimethoxyphenol is used in the preparation of 5,6-dimethoxy benzofuranone derivatives and multi-target anti Alzheimer compounds. It is also used in the preparation of 3,4-dimethoxyphenyl-beta-D-glucopyranoside and 4-(but-2-enyloxy)-1,2-dimethoxybenzene. Further, it serves as a precursor for 4H-chromenes synthesis.

Synthesis

3,4-Dimethoxyphenol is synthesised using Veratraldehyde as a raw material by chemical reaction. The specific synthesis steps are as follows:
Method (i): To a solution of vertraldehyde (2.11)(5 g,0.03 mole)in glacial acetic acid (30 ml)is added dropwise to a solution of peracetic acid5(15 ml) during 30 min.The temperature of the reaction mixture rises,it is kept at 40-45 by cooling.The reaction mixture is left for 10 hr and then concentrated to about 15 ml in vacuo.The residue is extracted with ether (2 x 20 ml).The ether layer is distilled.The formate ester of 3,4- dimethoxyphenol thus obtained is hydrolysed by refluxing with potassium hydroxide (10 g)in aqueous alcohol (1:4,100 ml)for 1 hr.The reaction mixture is concentrated in vacuo almost to dryness.It is dissolved in water (20 ml),the solution rendered acidic with dilute sulphuric acid and extracted with ether.The ether extract is dried (sodium sulphate)and distilled.The oily residue thus obtained is subjected to column chromatography over silica gel(2 x 30 cm).Elution with benzene gave 3,4-dimethoxyphenol as yellow solid.Yield 3g(65.2%).It is crystallised from  benzene as yellow crystalline needles.M.p.78-80(lit.m.p.78-80).
3,4-Dimethoxyphenol synthesis 1
Method (ii): A mixture of veratraldehyde (2.11)(1.66 g,0.01 mole),hydrogen peroxide (30%,2.6 ml,0.023 mole),p-toluenesulphonic acid (6.88 g, 0.036 mole)and methanol (5 ml)is stirred at room temperature.When the reaction is complete (as monitored by TLC)the reaction mixture is diluted with water (50 ml)and extracted with dichloromethane (5 x 50 ml).The extract is dried (anhydrous sodium sulphate)and purified by column chromatography over silica gel(2 x 30 cm).Elution with benzene gave 3,4. dimethoxyphenol as an yellow solid.Yield 1.16 g (75.3%).M.p.78-80.
3,4-Dimethoxyphenol synthesis 2

3,4-Dimethoxyphenol synthesis

120-14-9
2033-89-8
Synthesis of 3,4-Dimethoxyphenol from Veratraldehyde

3,4-Dimethoxyphenol Preparation Products And Raw materials

Raw materials

Phenol, 3,4-dimethoxy-, 1-formate 3,4,4-TRIMETHOXY-2,5-CYCLOHEXADIEN-1-ONE 2',4',6'-Trihydroxy-3'-methylbutyrophenone N-(3,4-dimethoxyphenyl)ethanamide 3,4-Dimethoxyphenylboronic acid
4-ALLYL-2,6-DIMETHOXYPHENOL Syringaldehyde 3-METHOXYCATECHOL 5-TERT-BUTYLPYROGALLOL 4-Bromoveratrole
Acetosyringone 4-HYDROXY-3-METHOXYPHENYLACETONE

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Preparation Products

BENZENE,1,2,4-TRIMETHOXY-5-(2-PROPENYL)- 4-Aminoveratrole 4-Ethylresorcinol

3,4-Dimethoxyphenol Suppliers

Global( 291)Suppliers
Supplier Tel Email Country ProdList Advantage
Springchem New Material Technology Co.,Limited 		+86-021-62885108 +8613917661608 info@spring-chem.com China 2068 57
Capot Chemical Co.,Ltd. 		571-85586718 +8613336195806 sales@capotchem.com China 29798 60
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32836 60
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29888 58
Hubei Jusheng Technology Co.,Ltd. 		18871490254 linda@hubeijusheng.com CHINA 28180 58
Hebei Guanlang Biotechnology Co., Ltd. 		+86-19930503282 alice@crovellbio.com China 8820 58
Shaanxi Pioneer Biotech Co., Ltd . 		+8613259417953 sales@pioneerbiotech.com China 3000 58
Hubei xin bonus chemical co. LTD 		86-13657291602 linda@hubeijusheng.com CHINA 22968 58
Chongqing Chemdad Co., Ltd 		+86-023-6139-8061 +86-86-13650506873 sales@chemdad.com China 39916 58
Wuhan Chemwish Technology Co., Ltd 		027-67849912 sales@chemwish.com CHINA 10828 58
Supplier Advantage
Springchem New Material Technology Co.,Limited 		57
Capot Chemical Co.,Ltd. 		60
ATK CHEMICAL COMPANY LIMITED 		60
career henan chemical co 		58
Hubei Jusheng Technology Co.,Ltd. 		58
Hebei Guanlang Biotechnology Co., Ltd. 		58
Shaanxi Pioneer Biotech Co., Ltd . 		58
Hubei xin bonus chemical co. LTD 		58
Chongqing Chemdad Co., Ltd 		58
Wuhan Chemwish Technology Co., Ltd 		58

View Lastest Price from 3,4-Dimethoxyphenol manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
3,4-DIMETHOXYPHENOL pictures 2024-09-19 3,4-DIMETHOXYPHENOL
2033-89-8
 US $0.00 / g 1g 98% 20tons Hubei Lidu New Material Technology Co., Ltd
3,4-Dimethoxyphenol pictures 2024-09-18 3,4-Dimethoxyphenol
2033-89-8
 US $0.00 / KG 1KG 98%min 30tons/month WUHAN FORTUNA CHEMICAL CO., LTD
3,4-Dimethoxyphenol pictures 2023-02-25 3,4-Dimethoxyphenol
2033-89-8
 US $0.00-0.00 / KG 1KG 99% 20 mt Hebei Guanlang Biotechnology Co., Ltd.

3,4-Dimethoxyphenol Spectrum

3,4-Dimethoxyphenol(2033-89-8)1HNMR

2033-89-8(3,4-Dimethoxyphenol)Related Search:

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4-HYDROXYVERATROLE Phenol, 3,4-dimethoxy- 3,4-Dimethoxyphenol,97% 3,4-Bis(Methyloxy)phenol 3,4-Dimethoxyphel 3,4-diMethoxyphenoxyl 3,4-dimethoxy-pheno 3,4-DIMETHOXYPHENOL NSC 140927 5‐Hydroxycatechol dimethyl ether 3,4-Dimethoxyphenol > 3,4-Dimethoxyphenol,>98% 3,4-Dimethoxyphenol, ≥ 97.0% 2033-89-8 Building Blocks Phenols Oxygen Compounds Organic Building Blocks Other Products Building Blocks C6 to C8 Chemical Synthesis Organic Building Blocks Oxygen Compounds Aromatic Phenols Phenol&Thiophenol&Mercaptan Aromatics Compounds Aromatics Phenyls & Phenyl-Het Organic Building Blocks Oxygen Compounds Phenols